J Clin Rheumatol:颈动脉和股动脉多普勒超声可以评估类女性风湿性关节炎患者心血管病的风险

2022-04-17 MedSci原创 MedSci原创

类风湿性关节炎(RA)是一种全身性的、慢性的、进行性的炎症性疾病,主要影响关节的滑膜,可导致骨质破坏。

类风湿性关节炎(RA)是一种全身性的、慢性的、进行性的炎症性疾病,主要影响关节的滑膜,可导致骨质破坏。近日,发表于J Clin Rheumatol的一项研基于旨在在欧洲抗风湿联盟(EULAR)推荐的乘以1.5之前和之后,评估被Framingham评分列为低风险的类风湿性关节炎(RA)患者的心血管风险,并使用颈动脉和股动脉多普勒超声(DUS)对其进行分层,以优化对无症状心血管疾病发病率的评估。

研究共纳入了35名女性RA患者和35名健康女性(对照组),根据Framingham评分,两者均为低心血管风险。所有这些人都接受了颈动脉和股动脉DUS研究。

 

结果,患者诊断时的平均年龄为44.57岁,平均病程为12.11年,根据疾病活动度评分28,平均疾病活动度评分为1.91,而根据临床疾病活动度指数为6.176。分析结果显示,在RA组中,46%的患者显示颈动脉和/或股动脉DUS有变化,而对照组中只有14%(P = 0.004)。在有异常的DUS中,RA组中31%的患者颈动脉DUS和81%的患者股动脉DUS(P = 0.005)显示出内膜中层厚度和/或动脉粥样硬化斑块。经过EULAR 1.5乘以系数后,66%的患者仍然属于低心血管风险。其中,35%的患者在颈动脉和/或股动脉DUS中显示出变化,而对照组只有14%(P = 0.07)。

综上所述,该研究结果表明,EULAR标准能有效识别心血管高危患者。颈动脉DUS,尤其是股动脉DUS是可以在临床实践中作为检测心血管疾病的工具,甚至在无症状的情况下也可使用。

原始出处:

Nathália de Carvalho Sacilotto, et al., Cardiovascular Risk Assessment in Women With Rheumatoid Arthritis Through Carotid and Femoral Artery Doppler Ultrasound. J Clin Rheumatol. 2022 Mar 1;28(2):e430-e432. doi: 10.1097/RHU.0000000000001755.

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    2022-04-17 西瓜0628

    学习了

    0

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    2022-04-18 lmm397
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