TSH可预测10 mm以上分化型甲状腺癌风险

2014-09-12 cath 整理 医学论坛网

解放军总医院内分泌科;第一作者现在北京市海淀医院闫慧娴、谷伟军和杨国庆等分析了血中促甲状腺激素(TSH)水平与甲状腺乳头状微小癌之间的相关性。结果表明,血清TSH是预测分化型甲状腺癌风险的指标之一,血清TSH可以对直径大于10 mm分化型甲状腺癌的风险进行预测,但它并不是甲状腺乳头状微小癌良好的预测因子。相关论文发表于2014年第8期《中华内分泌代谢杂志》。 研究者们回顾性分析了1999年10月

解放军总医院内分泌科;第一作者现在北京市海淀医院闫慧娴、谷伟军和杨国庆等分析了血中促甲状腺激素(TSH)水平与甲状腺乳头状微小癌之间的相关性。结果表明,血清TSH是预测分化型甲状腺癌风险的指标之一,血清TSH可以对直径大于10 mm分化型甲状腺癌的风险进行预测,但它并不是甲状腺乳头状微小癌良好的预测因子。相关论文发表于2014年第8期《中华内分泌代谢杂志》。

研究者们回顾性分析了1999年10月至2011年2月在解放军总医院收治的1 707例甲状腺结节患者临床资料,术后经病理证实良性结节1 070例、分化型甲状腺癌637例,按照病灶最大直径分为>10 mm和≤10 mm分化型甲状腺癌组,并对各组血清TSH水平进行比较分析。分化型甲状腺癌中直径≤10 mm的242例均为甲状腺乳头状微小癌。

结果显示,(1)分化型甲状腺癌患者血清TSH水平显著高于良性结节组[1.99(1.25~3.19)对1.48(0.85~2.32)mU/L, P<0.01];其中直径>10 mm分化型甲状腺癌患者血清TSH水平显著高于直径>10 mm良性结节组[2.04(1.26~3.36)对1.45(0.83~2.30)mU/L, P<0.01];直径≤10 mm分化型甲状腺癌组血清TSH水平与直径≤10 mm良性结节组之间无显著性差异。

(2)随着血清TSH水平的逐渐升高,甲状腺结节中分化型甲状腺癌患病率逐渐增加(P<0.01),直径>10 mm甲状腺结节患者中分化型甲状腺癌患者患病率随着血清TSH水平增加而呈增加趋势(P<0.05),但直径≤10 mm结节患者中分化型甲状腺癌患者患病率无此趋势(P>0.05)。

(3)logistic回归分析显示血清TSH是分化型甲状腺癌的独立危险因素;按甲状腺结节直径分组进行logistic回归分析显示血清TSH是直径>10 mm分化型甲状腺癌的独立危险因素;而血清TSH与直径≤10 mm分化型甲状腺癌之间无明显相关性。

论文标题:血清促甲状腺激素与甲状腺乳头状微小癌相关性研究


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    2015-06-05 ljjj1053

    好好学习学习

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=26059, encodeId=97012605936, content=好好学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Fri Jun 05 16:23:00 CST 2015, time=2015-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24397, encodeId=29582439ebd, content=通过大样本数据统计学分析得出的结论!!但有设计更严谨的前瞻性研究证实!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160515/IMG57380B859AD1F1019.jpg, createdBy=2c5c1621956, createdName=jasonuclear, createdTime=Thu May 21 12:34:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061441, encodeId=fe6e2061441e7, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Tue Mar 03 10:22:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=11640, encodeId=987811640f8, content=这完全是统计学得到的结论,很有发散意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5757106889, createdName=oubaochi, createdTime=Sun Sep 14 16:28:00 CST 2014, time=2014-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1322568, encodeId=45ed132256840, content=<a href='/topic/show?id=286c31525bd' target=_blank style='color:#2F92EE;'>#分化型甲状腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31525, encryptionId=286c31525bd, topicName=分化型甲状腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Sun Sep 14 00:22:00 CST 2014, time=2014-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407788, encodeId=af6c140e78877, content=<a href='/topic/show?id=e0731e891b9' target=_blank style='color:#2F92EE;'>#TSH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17891, encryptionId=e0731e891b9, topicName=TSH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Sun Sep 14 00:22:00 CST 2014, time=2014-09-14, status=1, ipAttribution=)]
    2015-05-21 jasonuclear

    通过大样本数据统计学分析得出的结论!!但有设计更严谨的前瞻性研究证实!

    0

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    2015-03-03 sjq027
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    2014-09-14 oubaochi

    这完全是统计学得到的结论,很有发散意义

    0

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