Circulation:左室功能恢复心衰患者预后较佳

2014-05-15 高晓方 译 医学论坛网

美国一项研究表明,左室功能恢复心衰(HF-R)患者的生物标志物谱和无事件生存率均优于射血分数降低心衰(HF-REF)和射血分数正常心衰(HF-PEF)患者,但其仍具有持续性心衰风险。论文于5月5日在线发表于《循环》(Circulation)。此项前瞻性研究共纳入1821例慢性心衰患者,并给予超声心动图将患者分为三类。以EF<50%定义HF-REF,以EF持续≥50%定义HF-PEF,以既往E

美国一项研究表明,左室功能恢复心衰(HF-R)患者的生物标志物谱和无事件生存率均优于射血分数降低心衰(HF-REF)和射血分数正常心衰(HF-PEF)患者,但其仍具有持续性心衰风险。论文于5月5日在线发表于《循环》(Circulation)。

此项前瞻性研究共纳入1821例慢性心衰患者,并给予超声心动图将患者分为三类。以EF<50%定义HF-REF,以EF持续≥50%定义HF-PEF,以既往EF<50%但治疗后≥50%定义HF-R。

结果显示,基线时相当一部分HF-R患者伴有异常生物标志物谱,包括44%伴有可检出肌钙蛋白I。HF-R患者的BNF、sFlt-1、肌钙蛋白I和肌酐中位水平高于HF-REF和HF-PEF患者。在最长随访8.9年期间,与HF-R患者相比,HF-REF患者的死亡、移植和心室辅助装置危险比(HR)为4.1,HF-PEF患者为2.3。与HF-R患者相比,HF-REF和HF-PEF患者的心源性住院HR分别为2.0和1.3。

原始出处:

Basuray A1, French B, Ky B, Vorovich E, Olt C, Sweitzer NK, Cappola TP, Fang JC.Heart Failure with Recovered Ejection Fraction: Clinical Description, Biomarkers, and Outcomes.Circulation. 2014 May 5. [Epub ahead of print]

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    2014-05-17 mnda

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