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Ann Surg ：NLR为HCC患者肝脏切除术后生存的独立预测因素

2013-07-04 ecoliDH5 dxy

AnnSurgNLRHCC肝脏切除术
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尽管相关报告认为，高中性粒细胞/淋巴细胞值(NLR)为各种肿瘤患者较差生存的预测因素，但尚未对肝细胞癌(HCC)患者进行过深入考察。对此，日本九州大学Ken Shirabe博士等人进行了一项研究，该研究针对因HCC而接受肝脏切除治疗的患者，旨在阐释术前NLR的预后价值。这项研究结果发表于2013年6月14日在线出版的《外科学年鉴》(Annals of Surgery)杂志上。该项回顾性研究共招募了

尽管相关报告认为，高中性粒细胞/淋巴细胞值(NLR)为各种肿瘤患者较差生存的预测因素，但尚未对肝细胞癌(HCC)患者进行过深入考察。对此，日本九州大学Ken Shirabe博士等人进行了一项研究，该研究针对因HCC而接受肝脏切除治疗的患者，旨在阐释术前NLR的预后价值。这项研究结果发表于2013年6月14日在线出版的《外科学年鉴》(Annals of Surgery)杂志上。

该项回顾性研究共招募了958例患者，这些HCC患者于1996年至2009年期间接受了肝脏切除治疗，患者均未接受过术前治疗。研究人员对包括NLR在内的临床病理参数进行了评价，以鉴定出肝脏切除术后总生存率及无复发生存率相关的预测因素。通过Cox比例风险模型进行了单变量和多变量分析。通过时间依赖型受试者工作特征曲线，确定得到最佳阈值。为确定NLR升高机制，还利用CD163染色法对150例患者进行了免疫组织检查。

单变量及多变量分析表明，NLR为总生存率及无复发生存率相关的独立预后因素。NLR最佳阈值为2.81，而在958例患者中，有238例(24.8%)患者的NLR高于2.81。对于NLR小于2.81的患者，在肝脏切除术后，其5年生存率为72.9%，而NLR值大于及等于2.81的患者则为51.5%(P < 0.0001)。与NLR小于2.81的患者相比，对于NLR值大于及等于2.81的患者，其肿瘤内阳性CD163细胞计数显著较高(P = 0.0004)。

这研究结果表明，NLR为HCC患者肝脏切除术后生存的独立预测因素。此外还发现，肿瘤相关的巨噬细胞积累与较高的NLR值有关。


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    2013-09-18 redcrab

    #肝脏切除术#

    0

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    2013-12-07 doctorzheng

    #切除术#

    0

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    2013-07-06 智智灵药

    #HCC#

    0

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    2013-07-06 朱睿睿

    #预测因素#

    0

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    2013-07-06 yuandd

    #NLR#

    0

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