美国风湿病学会(ACR)年会 2013 :女性长期喝碳酸饮料或患增类风湿性关节炎风险

2013-11-14 EGMN 爱思唯尔

圣迭戈——护士健康研究(NHS)与NHSⅡ汇总分析的结果显示,每天喝甜的碳酸饮料的女性罹患血清阳性类风湿性关节炎的风险大大增加。 在NHS的190万人-年和NHSⅡ的150万人-年的随访中,分别发生了563例确诊新发血清阳性类风湿性关节炎和320例血清阳性类风湿性关节炎。这两项研究共招募了238,131名定期填写饮食频率问卷的美国女性注册护士。 布里格姆妇女医院的Yang Hu医生在美

圣迭戈——护士健康研究(NHS)与NHSⅡ汇总分析的结果显示,每天喝甜的碳酸饮料的女性罹患血清阳性类风湿关节炎的风险大大增加。

在NHS的190万人-年和NHSⅡ的150万人-年的随访中,分别发生了563例确诊新发血清阳性类风湿性关节炎和320例血清阳性类风湿性关节炎。这两项研究共招募了238,131名定期填写饮食频率问卷的美国女性注册护士。

布里格姆妇女医院的Yang Hu医生在美国风湿病学会(ACR)年会上报告,在校正大量潜在混杂因素的多变量分析中,报告平均每天喝至少1份非膳食碳酸饮料的女性在随访期间罹患血清阳性类风湿性关节炎的风险,比不喝或每月喝少于1份碳酸饮料的女性增加71%(P=005)。

值得注意的是,风险增加的切点是每天喝1份碳酸饮料,而如今很多人并不认为这种频率算过量饮用。

研究者观察到的经常喝软饮料与血清阳性类风湿性关节炎相关的机制尚不清楚。研究者之所以决定观察含糖碳酸饮料,是因为它已被证明与超重与肥胖、2型糖尿病以及心血管疾病有关。而且由于肥胖已被证明与类风湿性关节炎风险增加有关,因此研究者曾猜测,肥胖可能介导了喝碳酸饮料与类风湿性关节炎的关联。但是,即使在校正体重指数的多变量分析中,每天喝碳酸饮料仍与风险增加 71%独立相关。

多变量分析中校正的其他潜在混杂因素包括,年龄、吸烟、饮酒、体力活动、生殖因素、服用复合维生素、收入水平,以及饮食质量。


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    2013-11-16 lmm397
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    2013-11-16 10518094zz
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