PLoS One:疱疹病毒和慢性牙周炎有啥关系?

2016-01-12 MedSci MedSci原创

已有大量的研究探究了疱疹病毒与慢性牙周炎之间的关系,但是,这些研究的结果仍存在争议。为了得到更精确的评价,本研究对所有可获得的研究进行一项荟萃分析以确定疱疹病毒与慢性牙周炎之间的关系。

已有大量的研究探究了疱疹病毒与慢性牙周炎之间的关系,但是,这些研究的结果仍存在争议。为了得到更精确的评价,本研究对所有可获得的研究进行一项荟萃分析以确定疱疹病毒与慢性牙周炎之间的关系。

根据纳入和排除标准确定 PubMed和EMBASE数据库中符合条件的病例对照研究。提取数据并计算汇集比值比和95%的可信区间以评估疱疹病毒与慢性牙周炎发生风险之间的关系。基于异质性测试确定使用固定或随机效应模型。进行敏感性分析以探究结果的稳定性和可靠性。采用Begg秩相关检验和Egger漏斗图分析来评估发表偏倚。

共纳入十项符合条件的研究来探究EB病毒(EBV)与慢性牙周炎之间的关系。结果表明,与牙周健康组相比,EB病毒与慢性牙周炎伴之间存在明显的关联(OR =5.74,95% CI = 2.53–13,P<0.001)。有十项研究分析了人巨细胞病毒(HCMV)与慢性牙周炎之间的关系。汇总结果表明,HCMV同样与慢性牙周炎的发生存在明显地关联(OR= 3.59,95% CI = 1.41–9.16,P = 0.007)。敏感性分析中也发现了类似的结果。并未发现明显地发表偏倚。符合纳入标准的两项研究中探讨了单纯疱疹病毒(HSV)与慢性牙周炎发生风险之间的关系。但是分析发现HSV与慢性牙周炎之间的关系是不确定的(OR= 2.81,95% CI = 0.95–8.27,P = 0.06)。仅有一项符合纳入标准的研究探究了人类疱疹病毒7型(HHV-7)与慢性牙周炎发生风险之间的关系(OR= 1,95% CI = 0.21–4.86)。

该荟萃分析的结果表明,疱疹病毒家族的两个成员:EBV和HCMV,与慢性牙周炎的发生存在明显地关联。并未有足够的证据支持HSV和HHV-7与慢性牙周炎的发生有关。

原始出处:

Ce Zhu, Fei Li, May. Chun. Mei Wong, Xi-Ping Feng, Hai-Xia Lu, Wei Xu. Association between Herpesviruses and Chronic Periodontitis: A Meta-Analysis Based on Case-Control Studies. PLoS One. 2015; 10(12): e0144319. Published online 2015 December 14. doi: 10.1371/journal.pone.0144319


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    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

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    2016-09-13 ylzr123

    好文拜读,认真学习了。

    0

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    2016-01-13 Lynee劲飞扬

    给力

    0

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    2016-01-13 xiaotaiyang1

    病毒研究逐渐兴起

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