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Neurology：显性遗传阿尔兹海默病的癫痫发作致病基因

2016-07-31 MedSci MedSci原创

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为了评估大型French队列中常染色体显性早发型阿尔兹海默病(ADEOAD)的癫痫发作次数和可能的诱发突变原因。 在法国进行了全国性的多中心研究， ADEOAD患者携带 PSEN1, PSEN2, APP致病性基因突变，或APP基因重复，最少随访时间5年，系统的记录临床、EEG和影像数据。 试验包含77个家族的132例患者：94人携带 PSEN1基因突变(MCs)，16人携带APP基因

为了评估大型French队列中常染色体显性早发型阿尔兹海默病(ADEOAD)的癫痫发作次数和可能的诱发突变原因。

在法国进行了全国性的多中心研究， ADEOAD患者携带 PSEN1, PSEN2, APP致病性基因突变，或APP基因重复，最少随访时间5年，系统的记录临床、EEG和影像数据。

试验包含77个家族的132例患者：94人携带 PSEN1基因突变(MCs)，16人携带APP基因重复，15 人携带 APP及MCs突变( APP MCs)，7人携带 PSEN2 MCs突变。中位随访8.4年(5-25年)，癫痫发作的频率为47.7%。5年随访后，使用Cox模型分析，携带基因突变的癫痫发作比例分别为，PSEN1组 19.1% (10.8%-26.7%) ；PSEN 228.6% (0%-55.3%)，APP重复 31.2% (4.3%-50.6%) 。APP基因重复携带者的癫痫风险较APP MCs突变组 (风险比 [HR] = 5.55 [95% CI1.87-16.44])和PSEN1 MCs 突变组(HR = 4.46 [2.11-9.44])显著增加。所有PSEN1突变，含有亲水性蛋白结构域 I，跨膜结构域 II (TM-II), TM-III, TM-IV, 和TM-VII的患者较含有其他结构域的患者癫痫发作风险显著增加 (HR = 4.53 [1.93-10.65], p = 0.0005)。

结论：癫痫是ADEOAD患者的常见特征。在这类人群中，APP 基因重复突变较其他突变类型癫痫发作风险显著增加。 PSEN1突变中，5种特殊结构域与更高的癫痫风险显著相关，表明致病突变与癫痫存在特定关联。

原始出处：

Zarea A1, Charbonnier C1, Rovelet-Lecrux A1, et al,Seizures in dominantly inherited Alzheimer disease.Neurology. 2016 Jul 27. pii: 10.1212/WNL.0000000000003048. [Epub ahead of print]

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    2016-09-29 yinhl1978

    #Neurol#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1999737, encodeId=8b541999e374c, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Sep 29 02:32:00 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145189, encodeId=662614518911, content=学习了，好文值得点赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:07:01 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=142714, encodeId=aee1142e143c, content=文章很好，继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Oct 09 16:03:01 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402689, encodeId=572d140268964, content=<a href='/topic/show?id=60ca9e761ce' target=_blank style='color:#2F92EE;'>#阿尔兹海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97761, encryptionId=60ca9e761ce, topicName=阿尔兹海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=be952422716, createdName=habb, createdTime=Tue Aug 02 02:32:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488502, encodeId=f9b51488502e3, content=<a href='/topic/show?id=b569864e51e' target=_blank style='color:#2F92EE;'>#致病基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86475, encryptionId=b569864e51e, topicName=致病基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6d1a8427162, createdName=wfang548, createdTime=Tue Aug 02 02:32:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95275, encodeId=5b5e952e546, content=癫痫的治疗任重而道远呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09f1636586, createdName=onetree, createdTime=Sun Jul 31 12:12:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95274, encodeId=0300952e407, content=也许开发出来基因靶向药物会给人类带来很多获益，可是现实是，研究的热火朝天，研究出来的药物也备受追捧，问题是太贵了，太贵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09f1636586, createdName=onetree, createdTime=Sun Jul 31 12:02:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95273, encodeId=0613952e3a4, content=敲除它！可惜基因研究了这么长时间，还是不能给人带来真正的获益, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09f1636586, createdName=onetree, createdTime=Sun Jul 31 12:00:00 CST 2016, time=2016-07-31, status=1, ipAttribution=)]
    2016-10-11 ylzr123

    学习了，好文值得点赞！

    0

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    2016-10-09 1e10c84am36(暂无匿称)

    文章很好，继续关注

    0

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    2016-08-02 habb

    #阿尔兹海默#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1999737, encodeId=8b541999e374c, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Sep 29 02:32:00 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145189, encodeId=662614518911, content=学习了，好文值得点赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:07:01 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=142714, encodeId=aee1142e143c, content=文章很好，继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Oct 09 16:03:01 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402689, encodeId=572d140268964, content=<a href='/topic/show?id=60ca9e761ce' target=_blank style='color:#2F92EE;'>#阿尔兹海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97761, encryptionId=60ca9e761ce, topicName=阿尔兹海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=be952422716, createdName=habb, createdTime=Tue Aug 02 02:32:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488502, encodeId=f9b51488502e3, content=<a href='/topic/show?id=b569864e51e' target=_blank style='color:#2F92EE;'>#致病基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86475, encryptionId=b569864e51e, topicName=致病基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6d1a8427162, createdName=wfang548, createdTime=Tue Aug 02 02:32:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95275, encodeId=5b5e952e546, content=癫痫的治疗任重而道远呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09f1636586, createdName=onetree, createdTime=Sun Jul 31 12:12:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95274, encodeId=0300952e407, content=也许开发出来基因靶向药物会给人类带来很多获益，可是现实是，研究的热火朝天，研究出来的药物也备受追捧，问题是太贵了，太贵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09f1636586, createdName=onetree, createdTime=Sun Jul 31 12:02:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95273, encodeId=0613952e3a4, content=敲除它！可惜基因研究了这么长时间，还是不能给人带来真正的获益, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09f1636586, createdName=onetree, createdTime=Sun Jul 31 12:00:00 CST 2016, time=2016-07-31, status=1, ipAttribution=)]
    2016-08-02 wfang548

    #致病基因#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1999737, encodeId=8b541999e374c, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Sep 29 02:32:00 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145189, encodeId=662614518911, content=学习了，好文值得点赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:07:01 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=142714, encodeId=aee1142e143c, content=文章很好，继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Oct 09 16:03:01 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402689, encodeId=572d140268964, content=<a href='/topic/show?id=60ca9e761ce' target=_blank style='color:#2F92EE;'>#阿尔兹海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97761, encryptionId=60ca9e761ce, topicName=阿尔兹海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=be952422716, createdName=habb, createdTime=Tue Aug 02 02:32:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488502, encodeId=f9b51488502e3, content=<a href='/topic/show?id=b569864e51e' target=_blank style='color:#2F92EE;'>#致病基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86475, encryptionId=b569864e51e, topicName=致病基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6d1a8427162, createdName=wfang548, createdTime=Tue Aug 02 02:32:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95275, encodeId=5b5e952e546, content=癫痫的治疗任重而道远呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09f1636586, createdName=onetree, createdTime=Sun Jul 31 12:12:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95274, encodeId=0300952e407, content=也许开发出来基因靶向药物会给人类带来很多获益，可是现实是，研究的热火朝天，研究出来的药物也备受追捧，问题是太贵了，太贵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09f1636586, createdName=onetree, createdTime=Sun Jul 31 12:02:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95273, encodeId=0613952e3a4, content=敲除它！可惜基因研究了这么长时间，还是不能给人带来真正的获益, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09f1636586, createdName=onetree, createdTime=Sun Jul 31 12:00:00 CST 2016, time=2016-07-31, status=1, ipAttribution=)]
    2016-07-31 onetree

    癫痫的治疗任重而道远呀

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1999737, encodeId=8b541999e374c, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Sep 29 02:32:00 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145189, encodeId=662614518911, content=学习了，好文值得点赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:07:01 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=142714, encodeId=aee1142e143c, content=文章很好，继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Oct 09 16:03:01 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402689, encodeId=572d140268964, content=<a href='/topic/show?id=60ca9e761ce' target=_blank style='color:#2F92EE;'>#阿尔兹海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97761, encryptionId=60ca9e761ce, topicName=阿尔兹海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=be952422716, createdName=habb, createdTime=Tue Aug 02 02:32:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488502, encodeId=f9b51488502e3, content=<a href='/topic/show?id=b569864e51e' target=_blank style='color:#2F92EE;'>#致病基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86475, encryptionId=b569864e51e, topicName=致病基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6d1a8427162, createdName=wfang548, createdTime=Tue Aug 02 02:32:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95275, encodeId=5b5e952e546, content=癫痫的治疗任重而道远呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09f1636586, createdName=onetree, createdTime=Sun Jul 31 12:12:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95274, encodeId=0300952e407, content=也许开发出来基因靶向药物会给人类带来很多获益，可是现实是，研究的热火朝天，研究出来的药物也备受追捧，问题是太贵了，太贵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09f1636586, createdName=onetree, createdTime=Sun Jul 31 12:02:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95273, encodeId=0613952e3a4, content=敲除它！可惜基因研究了这么长时间，还是不能给人带来真正的获益, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09f1636586, createdName=onetree, createdTime=Sun Jul 31 12:00:00 CST 2016, time=2016-07-31, status=1, ipAttribution=)]
    2016-07-31 onetree

    也许开发出来基因靶向药物会给人类带来很多获益，可是现实是，研究的热火朝天，研究出来的药物也备受追捧，问题是太贵了，太贵了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1999737, encodeId=8b541999e374c, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Sep 29 02:32:00 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145189, encodeId=662614518911, content=学习了，好文值得点赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:07:01 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=142714, encodeId=aee1142e143c, content=文章很好，继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Oct 09 16:03:01 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402689, encodeId=572d140268964, content=<a href='/topic/show?id=60ca9e761ce' target=_blank style='color:#2F92EE;'>#阿尔兹海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97761, encryptionId=60ca9e761ce, topicName=阿尔兹海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=be952422716, createdName=habb, createdTime=Tue Aug 02 02:32:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488502, encodeId=f9b51488502e3, content=<a href='/topic/show?id=b569864e51e' target=_blank style='color:#2F92EE;'>#致病基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86475, encryptionId=b569864e51e, topicName=致病基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6d1a8427162, createdName=wfang548, createdTime=Tue Aug 02 02:32:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95275, encodeId=5b5e952e546, content=癫痫的治疗任重而道远呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09f1636586, createdName=onetree, createdTime=Sun Jul 31 12:12:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95274, encodeId=0300952e407, content=也许开发出来基因靶向药物会给人类带来很多获益，可是现实是，研究的热火朝天，研究出来的药物也备受追捧，问题是太贵了，太贵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09f1636586, createdName=onetree, createdTime=Sun Jul 31 12:02:00 CST 2016, time=2016-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95273, encodeId=0613952e3a4, content=敲除它！可惜基因研究了这么长时间，还是不能给人带来真正的获益, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09f1636586, createdName=onetree, createdTime=Sun Jul 31 12:00:00 CST 2016, time=2016-07-31, status=1, ipAttribution=)]
    2016-07-31 onetree

    敲除它！可惜基因研究了这么长时间，还是不能给人带来真正的获益

    0