Nat Cell Biol：科学家找到控制前列腺癌进展和转移的代谢总开关

2016-06-10 佚名生物谷

最近，来自西班牙的科学家们在国际学术期刊Nature Cell Biology上发表了一项最新研究进展，他们发现一种参与代谢的转录共激活因子能够抑制前列腺癌进展和转移，这为找到对抗前列腺癌的新方法提供了重要方向。众所周知，细胞发生癌变以及癌症进展一般都会伴随代谢的变化。而一些参与代谢的主要共调节因子能够通过调节转录程序协调多条代谢途径参与癌症进展，因此这些共调节因子可能是调节代

最近，来自西班牙的科学家们在国际学术期刊Nature Cell Biology上发表了一项最新研究进展，他们发现一种参与代谢的转录共激活因子能够抑制前列腺癌进展和转移，这为找到对抗前列腺癌的新方法提供了重要方向。

众所周知，细胞发生癌变以及癌症进展一般都会伴随代谢的变化。而一些参与代谢的主要共调节因子能够通过调节转录程序协调多条代谢途径参与癌症进展，因此这些共调节因子可能是调节代谢重编程的关键分子。大量研究对癌症中单一代谢途径中单个酶分子或几个酶分子的调控进行研究，但是对于这些复杂代谢网络如何受到协同调控目前仍了解较少。

在这项最新研究中，研究人员设计了一种生物信息学分析方法整合多个前列腺癌数据集的数据发现转录共激活因子PGC1α在前列腺癌中发生表达下调，并且此现象与疾病进展具有相关性，因此研究人员提出PGC1α或抑制前列腺癌进展和转移。随后研究人员构建了基因工程小鼠模型和异种移植模型，通过一系列实验证明PGC1α确实能够对抗前列腺癌进展和转移。

研究人员还从机制上进行了深入分析，他们结合代谢组学和转录组学方法发现PGC1α能够激活雌激素相关受体α（ERRα）依赖性的转录程序，诱导细胞处于一种分解代谢状态，从而抑制癌症转移。研究人员还发现基于PGC1α-ERRα途径的基因表达特征在前列腺癌的诊断方面具有一定潜力。

这项研究结合生物信息学分析，组学分析和动物模型等方法发现在代谢中发挥重要作用的转录共调节因子PGC1α能够抑制前列腺癌进展和转移，为开发治疗前列腺癌的新方法提供了重要信息。

原始出处

Veronica Torrano,Lorea Valcarcel-Jimenez.et.al.The metabolic co-regulator PGC1α suppresses prostate cancer metastasis.Nat Cell Biol.2016

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#插入话题

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2016-12-26 12498ebem31暂无昵称

#Biol#

24 0
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2016-08-04 sunylz

#Bio#

23 0
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2017-03-16 liye789132251

#Nat#

37 0
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2016-06-19 zhaozhouchifen

#Cell#

34 0
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2016-12-25 维他命

#CEL#

24 0
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2016-06-12 Arthur M

代谢很重要

121 0
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2016-06-12 milkshark

的确这样

46 0
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2016-06-12 milkshark

比较深奥

39 0

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