消化系统肿瘤常出现肝转移,腹腔镜手术可减少损伤

2017-10-09 王鲁/复旦大学附属肿瘤医院肝脏外科主任 澎湃新闻

许多消化系统肿瘤如结直肠癌、胰腺癌、胃癌等都会发生肝转移癌,到了中晚期会发生转移,肝脏是这些肿瘤转移的好发地。以大肠癌为例,超过20%的大肠癌患者在初诊时已经出现了肝脏转移。而由于肝脏独特的解剖位置和血供特点,肝癌切除一直被视为“高危”手术。尽管外科医生不断更新诊疗指南、规范手术操作,但术后腹水、感染、肝功能不全、出血等并发症一直困扰着医患双方。以传统开放肝癌手术为例,经过医学专家的多方努力,其术

许多消化系统肿瘤如结直肠癌胰腺癌胃癌等都会发生肝转移癌,到了中晚期会发生转移,肝脏是这些肿瘤转移的好发地。以大肠癌为例,超过20%的大肠癌患者在初诊时已经出现了肝脏转移。而由于肝脏独特的解剖位置和血供特点,肝癌切除一直被视为“高危”手术。

尽管外科医生不断更新诊疗指南、规范手术操作,但术后腹水、感染、肝功能不全、出血等并发症一直困扰着医患双方。以传统开放肝癌手术为例,经过医学专家的多方努力,其术后并发症却仍然在15%以上,严重影响患者的生存和治疗效果。

目前,腹腔镜下切除肝脏肿瘤已经在复旦大学附属肿瘤医院得到普遍应用,其5年生存率与开放手术几乎相当,更重要的是,相对于开放手术,腹腔镜手术切口更小、视野更广,腹腔镜下切除肝脏肿瘤的并发症风险要低得多。

其实,自1991年世界首例腹腔镜肝切除术以来,腹腔镜技术不断成熟,在肝脏疾病中的应用已逐步得到认可和推广。目前,国内外开展腹腔镜肝脏切除手术的难度、范围已基本处于同一发展水平。临床研究表明,随着腹腔镜操作技术的不断熟练,腹腔镜肝脏切除术中、术后并发症发生率已与开腹手术无明显差异并且具有创伤小、术后恢复快、对病人免疫功能影响小等特点,其在操作技术上的可行性、安全性已逐步得到证实。

就大肠癌肝转移患者来说,目前数据表明,肝转移灶能够完全切除的肠癌患者5年生存率可达50%。遗憾的是,由于缺乏综合诊治平台,即便满足手术条件,发生肝转移的肠癌患者也往往需要两次手术才能切除病灶。加之开放手术带来的巨大创伤,从接受手术到化疗需要近两个月,可能延误术后辅助治疗时机。

在复旦大学附属肿瘤医院,每年收治肠癌肝转移患者200余例,其中1/4的患者可通过同期腹腔镜切除手术,一次性可以解决两个难题。手术期间,肝脏外科和大肠外科的医生强强联手,利用腹腔镜,通过细小切口,在同一台手术中切除肠癌原发灶和肝脏转移灶,病人术后10天左右即可进行后续化疗,并发症也可控制在10%以下,远低于联合开放手术25%的并发症风险。

此外,同期腔镜手术治疗费用也仅为两次开放手术的70%左右,大大减轻患者的经济负担。

然而,综合多种因素,目前并非所有肝脏肿瘤患者都适合在腹腔镜下切除。患者需满足以下几个条件:肿瘤没有侵犯肝脏主要管道、没有破裂出血、没有侵犯周围脏器、心肺功能较好。很多人会认为肿瘤尺寸会影响腔镜手术,但目前曾有病例是在腹腔镜下切除直径20cm以上的肝脏肿瘤,因此肿瘤尺寸并不会限制腔镜手术的开展。

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    2017-10-24 虈亣靌

    一起学习吧.很好的资源

    0

  3. 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Wed Oct 11 09:43:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443817, encodeId=bfa7144381e8d, content=<a href='/topic/show?id=6b058150307' target=_blank style='color:#2F92EE;'>#肝转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81503, encryptionId=6b058150307, topicName=肝转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea155117075, createdName=ms6747015003810650, createdTime=Wed Oct 11 09:43:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462665, encodeId=1c45146266545, content=<a href='/topic/show?id=bfec65e55e8' target=_blank style='color:#2F92EE;'>#消化系统#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65755, encryptionId=bfec65e55e8, topicName=消化系统)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00a96514473, createdName=jambiya, createdTime=Wed Oct 11 09:43:00 CST 2017, time=2017-10-11, status=1, ipAttribution=)]
    2017-10-22 thlabcde

    好资料学习了!

    0

  4. 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18:26:57 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252406, encodeId=b6e7252406ad, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri Oct 13 07:04:26 CST 2017, time=2017-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252236, encodeId=1eb82522366a, content=很好的专题,值得品味及分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/mzZkwf53jx0oribz8WkmVTPTSib4iaRMXz6nkEOaqWPjgyYWQoLa8J2WCicWvb8SrhhZz5sgUcwmQnMQ1lJcA7Fhxg/0, createdBy=9b182084756, createdName=yunger, createdTime=Thu Oct 12 14:48:21 CST 2017, time=2017-10-12, status=1, 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Wed Oct 11 09:43:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443817, encodeId=bfa7144381e8d, content=<a href='/topic/show?id=6b058150307' target=_blank style='color:#2F92EE;'>#肝转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81503, encryptionId=6b058150307, topicName=肝转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea155117075, createdName=ms6747015003810650, createdTime=Wed Oct 11 09:43:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462665, encodeId=1c45146266545, content=<a href='/topic/show?id=bfec65e55e8' target=_blank style='color:#2F92EE;'>#消化系统#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65755, encryptionId=bfec65e55e8, topicName=消化系统)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00a96514473, createdName=jambiya, createdTime=Wed Oct 11 09:43:00 CST 2017, time=2017-10-11, status=1, ipAttribution=)]
    2017-10-15 虈亣靌

    学习了.获益匪浅!感谢分享

    0

  5. 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Wed Oct 11 09:43:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443817, encodeId=bfa7144381e8d, content=<a href='/topic/show?id=6b058150307' target=_blank style='color:#2F92EE;'>#肝转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81503, encryptionId=6b058150307, topicName=肝转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea155117075, createdName=ms6747015003810650, createdTime=Wed Oct 11 09:43:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462665, encodeId=1c45146266545, content=<a href='/topic/show?id=bfec65e55e8' target=_blank style='color:#2F92EE;'>#消化系统#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65755, encryptionId=bfec65e55e8, topicName=消化系统)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00a96514473, createdName=jambiya, createdTime=Wed Oct 11 09:43:00 CST 2017, time=2017-10-11, status=1, ipAttribution=)]
    2017-10-13 yfjms

    学习了

    0

  6. 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18:26:57 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252406, encodeId=b6e7252406ad, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri Oct 13 07:04:26 CST 2017, time=2017-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252236, encodeId=1eb82522366a, content=很好的专题,值得品味及分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/mzZkwf53jx0oribz8WkmVTPTSib4iaRMXz6nkEOaqWPjgyYWQoLa8J2WCicWvb8SrhhZz5sgUcwmQnMQ1lJcA7Fhxg/0, createdBy=9b182084756, createdName=yunger, createdTime=Thu Oct 12 14:48:21 CST 2017, time=2017-10-12, status=1, 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Wed Oct 11 09:43:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443817, encodeId=bfa7144381e8d, content=<a href='/topic/show?id=6b058150307' target=_blank style='color:#2F92EE;'>#肝转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81503, encryptionId=6b058150307, topicName=肝转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea155117075, createdName=ms6747015003810650, createdTime=Wed Oct 11 09:43:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462665, encodeId=1c45146266545, content=<a href='/topic/show?id=bfec65e55e8' target=_blank style='color:#2F92EE;'>#消化系统#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65755, encryptionId=bfec65e55e8, topicName=消化系统)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00a96514473, createdName=jambiya, createdTime=Wed Oct 11 09:43:00 CST 2017, time=2017-10-11, status=1, ipAttribution=)]
    2017-10-12 yunger

    很好的专题,值得品味及分享

    0

  7. 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  8. 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18:26:57 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252406, encodeId=b6e7252406ad, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri Oct 13 07:04:26 CST 2017, time=2017-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252236, encodeId=1eb82522366a, content=很好的专题,值得品味及分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/mzZkwf53jx0oribz8WkmVTPTSib4iaRMXz6nkEOaqWPjgyYWQoLa8J2WCicWvb8SrhhZz5sgUcwmQnMQ1lJcA7Fhxg/0, createdBy=9b182084756, createdName=yunger, createdTime=Thu Oct 12 14:48:21 CST 2017, time=2017-10-12, status=1, 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  9. 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  10. 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Wed Oct 11 09:43:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443817, encodeId=bfa7144381e8d, content=<a href='/topic/show?id=6b058150307' target=_blank style='color:#2F92EE;'>#肝转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81503, encryptionId=6b058150307, topicName=肝转移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea155117075, createdName=ms6747015003810650, createdTime=Wed Oct 11 09:43:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462665, encodeId=1c45146266545, content=<a href='/topic/show?id=bfec65e55e8' target=_blank style='color:#2F92EE;'>#消化系统#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65755, encryptionId=bfec65e55e8, topicName=消化系统)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00a96514473, createdName=jambiya, createdTime=Wed Oct 11 09:43:00 CST 2017, time=2017-10-11, status=1, ipAttribution=)]