J Mycol Med:广藿香和肉桂精油对念珠菌生物膜和菌丝形成的作用

2018-04-01 MedSci MedSci原创

尽管在抗真菌治疗领域取得了重大进展,但生物膜相关念珠菌感染的流行率和死亡率仍然是医疗领域所面临的一大挑战。传统上,来自芳香植物的精油(EO)被认为是治疗真菌疾病的一种较为优秀的治疗剂。本研究探讨了从广藿香(PH)提取的EOs,柴桂(CT)提取的印度肉桂和从樟脑EO(CC)中提取的印度EO对念珠菌的抗微生物和抗生物膜效应。研究人员探究了Eos对未成熟及已形成的念珠菌生物膜的破坏作用,并探究了其抑制酵

尽管在抗真菌治疗领域取得了重大进展,但生物膜相关念珠菌感染的流行率和死亡率仍然是医疗领域所面临的一大挑战。传统上,来自芳香植物的精油(EO)被认为是治疗真菌疾病的一种较为优秀的治疗剂。本研究探讨了从广藿香(PH)提取的EOs,柴桂(CT)提取的印度肉桂和从樟脑EO(CC)中提取的印度EO对念珠菌的抗微生物和抗生物膜效应。

研究人员探究了Eos对未成熟及已形成的念珠菌生物膜的破坏作用,并探究了其抑制酵母到菌丝的转变成的效果。通过XTT测定评估这些EO抑制代谢活性细胞的能力。

结果显示,在这三种EOs中,CT EO的生物膜抑制作用更强,因此进一步选择它来研究其生物量抑制潜力和胞外多糖层破坏能力。共聚焦显微镜检测结果发现,CT EO降低了三种念珠菌菌株的预形成生物膜的生物量。扫描电子显微镜检测还发现,CT EO破坏了念珠菌菌株的胞外多糖层。

综上所述,该研究结果验证了EOs对念珠菌属毒力的有效性。并强调了几种天然但尚未开发的野生芳香植物在治疗应用前景中的药用潜力。

原始出处:

Farisa Banu S, Rubini D, et al., Effects of patchouli and cinnamon essential oils on biofilm and hyphae formation by Candida species. J Mycol Med. 2018 Mar 20. pii: S1156-5233(17)30378-5. doi: 10.1016/j.mycmed.2018.02.012.

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    2018-04-03 guihongzh
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    2018-04-01 清风拂面

    谢谢分享学习

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