EHJ:直接PCI术中血栓抽吸可降低STEMI患者死亡率

2012-10-03 张一宸译 医学论坛网

     9月17日《欧洲心脏杂志》(Eur Heart J)发表一项针对真实世界的非选择性ST段抬高心肌梗死患者(STEMI)的研究,结果表明尤其对于总缺血时间较短的患者,直接经皮冠脉介入治疗(PPCI)术中行血栓抽吸可显著降低死亡率。  研究者于2008-2011年间共搜集2567例接受PPCI治疗的STEMI 患者。采用Cox比例风险模型和多元逻辑回归分析校正

  血栓抽吸

  9月17日《欧洲心脏杂志》(Eur Heart J)发表一项针对真实世界的非选择性ST段抬高心肌梗死患者(STEMI)的研究,结果表明尤其对于总缺血时间较短的患者,直接经皮冠脉介入治疗(PPCI)术中行血栓抽吸可显著降低死亡率。
  研究者于2008-2011年间共搜集2567例接受PPCI治疗的STEMI 患者。采用Cox比例风险模型和多元逻辑回归分析校正已知协变量。1095例患者接受血栓切除术(42.7%)。血栓摘除组患者PPCI术后溶栓更易达到3级血流[校正比值比(OR)1.92, 95%置信区间(CI): 1.34–2.76, P=0.0004]。血栓切除显著降低住院[校正OR: 0.51, 95% CI: 0.29–0.93, P=0.027]及较长期死亡率[校正危险比(HR):0.69, 95% CI: 0.48–0.96, P=0.028]。倾向加权分析接受血栓切除术的患者较长期死亡率校正HR为0.43 (95% CI: 0.19–0.97; P=0.042)。血栓切除和降低较长期死亡率相关性在总缺血时间≤180min的患者中有显著意义(P=0.001),在缺血时间>180 min患者中无显著意义。(P=0.99)。

  链接:

Noman A, Egred M, Bagnall A, Spyridopoulos I, Jamieson S, Ahmed J.Impact of thrombus aspiration during primary percutaneous coronary intervention on mortality in ST-segment elevation myocardial infarction. Eur Heart J. 2012 Sep 17



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    2012-10-21 zxl736
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    2013-03-07 xuyu
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