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J Transl Med：复合非脱矿质异种牙本质与β-磷酸三钙可有效修复牙槽突裂

2018-01-21 MedSci MedSci原创

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牙槽裂修复通常是通过骨移植手术来恢复牙弓的连续性。合适的骨替代材料应具有骨诱导性和骨传导性以促进新骨形成，以及随后功能性的骨代替缓慢可吸收的支架。研究已证实磷酸钙生物材料可作为骨替代材料。既往几项研究显示，几种形式的牙本质也显示出其可用作骨移植替代材料的可能性。本研究旨在评价复合异种牙本质和β-TCP与单独β-TCP相比在实验性牙槽裂隙缺损模型中的骨再生的模式及效果。研究使用16只新西兰兔建立单侧

牙槽裂修复通常是通过骨移植手术来恢复牙弓的连续性。合适的骨替代材料应具有骨诱导性和骨传导性以促进新骨形成，以及随后功能性的骨代替缓慢可吸收的支架。研究已证实磷酸钙生物材料可作为骨替代材料。既往几项研究显示，几种形式的牙本质也显示出其可用作骨移植替代材料的可能性。本研究旨在评价复合异种牙本质和β-TCP与单独β-TCP相比在实验性牙槽裂隙缺损模型中的骨再生的模式及效果。

研究使用16只新西兰兔建立单侧牙槽裂隙缺陷模型。牙槽嵴裂允许8周愈合期。8个缺损使用β-TCP填充，其余8个缺陷填充复合异种牙本质和β-TCP。干预后8周比较愈合缺陷的骨再生情况。使用微型计算机断层摄影术（μCT）和组织形态学分析来分析骨形成的量。

结果显示，μCT和组织形态学分析显示，与单独的β-TCP相比，复合牙本质/β-TCP填充的缺陷显示统计学上更高的骨体积分数，骨矿物质密度和残余移植体积百分比。此外，研究人员还注意到复合牙本质/β-TCP移植物的改进的手术操作。

综上所述，该研究结果表明，与单独使用β-TCP相比，复合异种牙本质/β-TCP在兔牙槽突裂缺损的重建中表现出增强的骨再生能力。

原始出处：

Mohammad Kamal, Lars Andersson, et al., Bone regeneration using composite non-demineralized xenogenic dentin with beta-tricalcium phosphate in experimental alveolar cleft repair in a rabbit model. J Transl Med. 2017; 15: 263. doi:  10.1186/s12967-017-1369-3

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    2018-04-17 bsmagic9140

    #TRA#

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    2018-12-23 zhouqu_8

    #磷酸三钙#

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    2018-01-23 ms3994565386320060

    #Med#

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