PLoS One:术中通气泄漏可以预测肺切除术后的延长漏气

2017-11-14 xiangting MedSci原创

VL是术中漏气的定量指标及术后PAL的独立预测因子。

延长漏气(PAL),被定义为肺切除术后漏气超过5天,与多种不良结局相关。然而,关于PAL术中危险因素的研究还不够充分。这项研究旨在调查术中通气泄漏(VL)是否可以预测PAL。

研究人员对1060例肺切除术后留置胸管的患者进行了回顾性研究。从电子麻醉记录中获取潮气量数据。通气泄漏(%)计算为[(吸气潮气量 - 呼气潮气量)/吸气潮气量×100],并在双肺通气重启后进行测量。使用VL作为预测因子,PAL作为相关结果进行Cox比例风险回归分析。然后通过添加可能的风险因素,包括患者特征、肺功能和手术因素来调整VL的优势比。

PAL的发生率为18.7%。在单变量分析中VL> 9.5%是PAL的重要预测指标。在调整7个额外的危险因素包括男性,年龄> 60岁,体重指数<21.5 kg/m2,1秒用力呼气量<80%,开胸,大肺切除,以及单肺通气时间>2.1小时后,VL仍然是PAL显著预测因子(1.59,95%CI,1.37-1.85,P <0.001)。预测模型的C统计量为0.80(95%CI,0.77-0.82)。

总之,VL是术中漏气的定量指标及术后PAL的独立预测因子。在肺切除术期间监测VL有助于对相关患者推荐额外手术修复或辅助治疗,从而减少术后PAL。

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    2017-11-15 李东泽

    是很好的学习材料.不错.以后会多学习.

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