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Am J Gastroenterol：原发性胆汁性胆管炎与甲状腺功能异常

2016-10-27 MedSci MedSci原创

原发性胆汁性胆管炎甲状腺炎症
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原发性胆汁性胆管炎（PBC）常与其他自身免疫性疾病有关，但关于甲状腺疾病的影响（TD）对PBC自然史的影响，我们知之甚少。我们的目的是分析PBC和TD之间的关联。这项研究涉及921例PBC患者，纳入时间为1975-2015年，地点为帕多瓦市（376例）、巴塞罗那（545例）平均随访126.9±91.7个月。共150例（16.3 %）有TD，包括94例（10.2%）Hashimoto甲状腺炎，15例

原发性胆汁性胆管炎（PBC）常与其他自身免疫性疾病有关，但关于甲状腺疾病的影响（TD）对PBC自然史的影响，我们知之甚少。我们的目的是分析PBC和TD之间的关联。这项研究涉及921例PBC患者，纳入时间为1975-2015年，地点为帕多瓦市（376例）、巴塞罗那（545例）平均随访126.9±91.7个月。共150例（16.3 %）有TD，包括94例（10.2%）Hashimoto甲状腺炎，15例（1.6 %）Graves疾病，22例 (2.4%)多结节性甲状腺肿，7例 (0.8%)甲状腺癌和12例 (1.3%)其他甲状腺疾病。帕多瓦市和巴塞罗那的不同类型的TD的患病率相似，但是除了Graves病和甲状腺癌，这在帕多瓦市组更频繁(15.7 vs. 5.0%,8.6 vs. 1.3%,P<0.05)。总的来说，PBC患者诊断时组织学有或没有TD、肝功能代偿失调、发生肝癌或肝移植率无关。PBC患者存在TD与更低的生存率无关。TDs与自身免疫性TD，尤其是桥本氏甲状腺炎，常合并PBC，但TD的存在并不影响肝并发症发生率或PBC的自然史。原始出处：Annarosa Floreani,et

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    2017-07-07 jiyangfei

    #原发性#

    0

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    2016-11-21 hb2008ye

    #胆汁性#

    0

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time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628278, encodeId=7ac516282e85a, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Sat Oct 29 08:15:00 CST 2016, time=2016-10-29, status=1, ipAttribution=)]
    2017-05-20 zhouqu_8

    #功能异常#

    0

  4. 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createdName=hb2008ye, createdTime=Mon Nov 21 00:15:00 CST 2016, time=2016-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914346, encodeId=5c8c19143466e, content=<a href='/topic/show?id=7c90328e6f1' target=_blank style='color:#2F92EE;'>#功能异常#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32876, encryptionId=7c90328e6f1, topicName=功能异常)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat May 20 06:15:00 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071684, encodeId=e04820e1684bf, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Wed Jul 19 01:15:00 CST 2017, time=2017-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710943, encodeId=abfe1e10943d6, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Jul 02 07:15:00 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064019, encodeId=d17d206401923, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Wed Jun 14 14:15:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152599, encodeId=6c2c152599ac, content=谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Nov 01 10:17:02 CST 2016, time=2016-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379011, encodeId=ddea13e901183, content=<a href='/topic/show?id=8f633e1073d' target=_blank style='color:#2F92EE;'>#原发性胆汁性胆管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37107, encryptionId=8f633e1073d, topicName=原发性胆汁性胆管炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec53439, createdName=zhty5337, createdTime=Sat Oct 29 08:15:00 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579161, encodeId=2b8615e916137, content=<a href='/topic/show?id=372b834e673' target=_blank style='color:#2F92EE;'>#胆汁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83476, encryptionId=372b834e673, topicName=胆汁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a0616505872, createdName=108807375_62823132, createdTime=Sat Oct 29 08:15:00 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628278, encodeId=7ac516282e85a, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Sat Oct 29 08:15:00 CST 2016, time=2016-10-29, status=1, ipAttribution=)]
    2017-07-19 许安

    #GAS#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1846516, encodeId=99d618465167d, content=<a href='/topic/show?id=d3a33e0306d' target=_blank style='color:#2F92EE;'>#原发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37030, encryptionId=d3a33e0306d, topicName=原发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Fri Jul 07 15:15:00 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809368, encodeId=7bcc1809368c9, content=<a href='/topic/show?id=5eba834e876' target=_blank style='color:#2F92EE;'>#胆汁性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83478, encryptionId=5eba834e876, topicName=胆汁性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, 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href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Wed Jun 14 14:15:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152599, encodeId=6c2c152599ac, content=谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Nov 01 10:17:02 CST 2016, time=2016-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379011, encodeId=ddea13e901183, content=<a href='/topic/show?id=8f633e1073d' target=_blank style='color:#2F92EE;'>#原发性胆汁性胆管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37107, encryptionId=8f633e1073d, topicName=原发性胆汁性胆管炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec53439, createdName=zhty5337, createdTime=Sat Oct 29 08:15:00 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579161, encodeId=2b8615e916137, content=<a href='/topic/show?id=372b834e673' target=_blank style='color:#2F92EE;'>#胆汁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83476, encryptionId=372b834e673, topicName=胆汁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a0616505872, createdName=108807375_62823132, createdTime=Sat Oct 29 08:15:00 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628278, encodeId=7ac516282e85a, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Sat Oct 29 08:15:00 CST 2016, time=2016-10-29, status=1, ipAttribution=)]
    2017-07-02 ms24272190615788285182

    #AST#

    0

  6. 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href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Wed Jun 14 14:15:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=152599, encodeId=6c2c152599ac, content=谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Nov 01 10:17:02 CST 2016, time=2016-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379011, encodeId=ddea13e901183, content=<a href='/topic/show?id=8f633e1073d' target=_blank style='color:#2F92EE;'>#原发性胆汁性胆管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37107, encryptionId=8f633e1073d, topicName=原发性胆汁性胆管炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec53439, createdName=zhty5337, createdTime=Sat Oct 29 08:15:00 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579161, encodeId=2b8615e916137, content=<a href='/topic/show?id=372b834e673' target=_blank style='color:#2F92EE;'>#胆汁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83476, encryptionId=372b834e673, topicName=胆汁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a0616505872, createdName=108807375_62823132, createdTime=Sat Oct 29 08:15:00 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628278, encodeId=7ac516282e85a, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Sat Oct 29 08:15:00 CST 2016, time=2016-10-29, status=1, ipAttribution=)]
    2017-06-14 jktdtl

    #Gastroenterol#

    0

  7. 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time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628278, encodeId=7ac516282e85a, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Sat Oct 29 08:15:00 CST 2016, time=2016-10-29, status=1, ipAttribution=)]
    2016-11-01 xyfg98

    谢谢分享！

    0

  8. 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href='/topic/show?id=8f633e1073d' target=_blank style='color:#2F92EE;'>#原发性胆汁性胆管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37107, encryptionId=8f633e1073d, topicName=原发性胆汁性胆管炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec53439, createdName=zhty5337, createdTime=Sat Oct 29 08:15:00 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579161, encodeId=2b8615e916137, content=<a href='/topic/show?id=372b834e673' target=_blank style='color:#2F92EE;'>#胆汁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83476, encryptionId=372b834e673, topicName=胆汁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a0616505872, createdName=108807375_62823132, createdTime=Sat Oct 29 08:15:00 CST 2016, time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628278, encodeId=7ac516282e85a, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Sat Oct 29 08:15:00 CST 2016, time=2016-10-29, status=1, ipAttribution=)]
    2016-10-29 zhty5337

    #原发性胆汁性胆管炎#

    0

  9. 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time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628278, encodeId=7ac516282e85a, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Sat Oct 29 08:15:00 CST 2016, time=2016-10-29, status=1, ipAttribution=)]
    2016-10-29 108807375_62823132

    #胆汁#

    0

  10. 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time=2016-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628278, encodeId=7ac516282e85a, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Sat Oct 29 08:15:00 CST 2016, time=2016-10-29, status=1, ipAttribution=)]
    2016-10-29 cmj15wellington

    #胆管#

    0

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背景：原发性胆汁性胆管炎（PBC）患者可能会因为胆汁淤积和/或炎症过程，导致大脑的变化；这种变化与疲劳和认知功能障碍的系统性症状有关。 目的：探究早期PBC是否会发生大脑变化；如果早期出现大脑变化并出现进展，那么可以解释为什么这些症状会这么难治。 方法：使用磁化传递、弥散加权成像和1H磁共振波谱分析，对13名活检证实非肝硬化PBC患者进行了疾病早期大脑变化分析；并与17名健康志愿者的结