Eur Heart J:慢性阻塞性肺疾病患者心源性猝死风险增加(Rotterdam研究)

2015-05-07 张旭栋译 MedSci原创

比利时,根特大学医院Lies Lahousse等人研究了慢性阻塞性肺病与心源性猝死之间的关联,其研究成果发表在4月份European heart journal期刊上。 目的:心源性猝死(SCD)和慢性阻塞性肺疾病(COPD)在中老年人中是常见的疾病。之前已有研究明确了普通人群中慢性阻塞性肺病和心血管疾病之间存在一定的关联,尤其是与心源性猝死之间的关联。本研究旨在调查普通人群中慢性阻塞性肺病

比利时,根特大学医院Lies Lahousse等人研究了慢性阻塞性肺病与心源性猝死之间的关联,其研究成果发表在4月份European heart journal期刊上。

目的:心源性猝死(SCD)和慢性阻塞性肺疾病(COPD)在中老年人中是常见的疾病。之前已有研究明确了普通人群中慢性阻塞性肺病和心血管疾病之间存在一定的关联,尤其是与心源性猝死之间的关联。本研究旨在调查普通人群中慢性阻塞性肺病和心源性猝死之间的关联。

方法和结果:鹿特丹研究,基于14926例45岁及以上的患者,并对其进行了为期长达24年的随访研究。调整年龄、性别以及吸烟因素后,建立Cox比例风险模型(具有时间依赖性)。研究纳入了13471例患者,1615例患者诊断为慢性阻塞性肺病,其中551例患者发生心源性猝死。结果提示慢性阻塞性肺疾病患者的心源性猝死风险升高(年龄和性别调整后的危险比,HR,1.34; 95%CI为1.06-1.70)。慢性阻塞性肺病(年龄和性别调整HR2.12,95%CI1.60-2.82)诊断后2000天(5.48年)时,患者心源性猝死风险升高更为显著,在此期间COPD患者心源性猝死风险增加超过三倍(年龄和性别调整后HR3.58,95%CI为2.35-5.44)。分析人群主要为没有肌梗死或心脏衰竭的患者,并且得到了相似的结果。

结论:慢性阻塞性肺疾病患者心源性猝死风险增加,尤其在慢性阻塞性肺病诊断5年后,病情频繁加剧的人群中更为显著。这项风险预测指标能够更好,并有针对性地预防心源性猝死。

原文出处:

Lahousse L, Niemeijer MN, van den Berg ME, Rijnbeek PR, Joos GF, Hofman A, Franco OH, Deckers JW, Eijgelsheim M, Stricker BH, Brusselle GG. Chronic obstructive pulmonary disease and sudden cardiac death: the Rotterdam study. European heart journal. 2015.

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    2015-07-27 tomyang96
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level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu May 07 21:07:00 CST 2015, time=2015-05-07, status=1, ipAttribution=)]
    2015-05-10 hbwang006

    右心衰了,当然不好

    0

  5. 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level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu May 07 21:07:00 CST 2015, time=2015-05-07, status=1, ipAttribution=)]
    2015-05-09 zhaojie88
  6. 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  7. 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level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu May 07 21:07:00 CST 2015, time=2015-05-07, status=1, ipAttribution=)]
    2015-05-09 slcumt
  8. [GetPortalCommentsPageByObjectIdResponse(id=1696646, encodeId=eb25169664651, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Mon Jul 27 16:33:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798940, encodeId=d3b61e98940b9, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, 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createdTime=Sun May 10 22:45:00 CST 2015, time=2015-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355983, encodeId=6bdc135598352, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat May 09 05:33:00 CST 2015, time=2015-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542907, encodeId=a758154290e6f, content=<a href='/topic/show?id=a93d681e1ff' target=_blank style='color:#2F92EE;'>#猝死风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68171, encryptionId=a93d681e1ff, topicName=猝死风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=921913505832, createdName=ms3323097325231039, createdTime=Sat May 09 05:33:00 CST 2015, time=2015-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562305, encodeId=862d1562305b2, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sat May 09 05:33:00 CST 2015, time=2015-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1593408, encodeId=28941593408a4, content=<a href='/topic/show?id=9850510e9a3' target=_blank style='color:#2F92EE;'>#心源性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51079, encryptionId=9850510e9a3, topicName=心源性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=955718147815, createdName=mhm295, createdTime=Sat May 09 05:33:00 CST 2015, time=2015-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22916, encodeId=cb8c22916aa, content=看过了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Thu May 07 22:30:00 CST 2015, time=2015-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22886, encodeId=112222886b8, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu May 07 21:07:00 CST 2015, time=2015-05-07, status=1, ipAttribution=)]
    2015-05-09 mhm295
  9. [GetPortalCommentsPageByObjectIdResponse(id=1696646, encodeId=eb25169664651, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Mon Jul 27 16:33:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798940, encodeId=d3b61e98940b9, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, 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createdTime=Sun May 10 22:45:00 CST 2015, time=2015-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355983, encodeId=6bdc135598352, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat May 09 05:33:00 CST 2015, time=2015-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542907, encodeId=a758154290e6f, content=<a href='/topic/show?id=a93d681e1ff' target=_blank style='color:#2F92EE;'>#猝死风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68171, encryptionId=a93d681e1ff, topicName=猝死风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=921913505832, createdName=ms3323097325231039, createdTime=Sat May 09 05:33:00 CST 2015, time=2015-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562305, encodeId=862d1562305b2, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sat May 09 05:33:00 CST 2015, time=2015-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1593408, encodeId=28941593408a4, content=<a href='/topic/show?id=9850510e9a3' target=_blank style='color:#2F92EE;'>#心源性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51079, encryptionId=9850510e9a3, topicName=心源性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=955718147815, createdName=mhm295, createdTime=Sat May 09 05:33:00 CST 2015, time=2015-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22916, encodeId=cb8c22916aa, content=看过了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Thu May 07 22:30:00 CST 2015, time=2015-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22886, encodeId=112222886b8, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu May 07 21:07:00 CST 2015, time=2015-05-07, status=1, ipAttribution=)]
    2015-05-07 zhouanxiu

    看过了

    0

  10. 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attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=921913505832, createdName=ms3323097325231039, createdTime=Sat May 09 05:33:00 CST 2015, time=2015-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562305, encodeId=862d1562305b2, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sat May 09 05:33:00 CST 2015, time=2015-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1593408, encodeId=28941593408a4, content=<a href='/topic/show?id=9850510e9a3' target=_blank style='color:#2F92EE;'>#心源性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51079, encryptionId=9850510e9a3, topicName=心源性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=955718147815, createdName=mhm295, createdTime=Sat May 09 05:33:00 CST 2015, time=2015-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22916, encodeId=cb8c22916aa, content=看过了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Thu May 07 22:30:00 CST 2015, time=2015-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22886, encodeId=112222886b8, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu May 07 21:07:00 CST 2015, time=2015-05-07, status=1, ipAttribution=)]
    2015-05-07 huaxipanxing

    看看

    0

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