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ANN ONCOL：Ⅰ/Ⅱ期NK/T细胞淋巴瘤序贯化疗/放疗与同时放化疗效果相似

2018-01-27 MedSci MedSci原创

NK/T细胞淋巴瘤放疗化疗
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在Ⅰ/Ⅱ期NK/T细胞淋巴瘤中，同时放化疗（CCRT）已被证明效果优于蒽环类化疗，从那之后蒽环类化疗便被认为疗效不佳。在这类患者汇总，CCRT和非蒽环类化疗联合序贯放疗的比较尚需进一步阐明。ANN ONCOL近期发表了一篇文章研究这一问题

在Ⅰ/Ⅱ期NK/T细胞淋巴瘤中，同时放化疗（CCRT）已被证明效果优于蒽环类化疗，从那之后蒽环类化疗便被认为疗效不佳。在这类患者汇总，CCRT和非蒽环类化疗联合序贯放疗的比较尚需进一步阐明。ANN ONCOL近期发表了一篇文章研究这一问题。

作者收集了303例接受非蒽环类化疗的Ⅰ/Ⅱ期NK/T细胞淋巴瘤患者资料进行分析。治疗措施包括单模式（CT+RT），序贯模式（CT+RT；RT+CT）和同时模式（CCRT；CCRT+CT）。评估临床病理特征以及治疗方式对完全反应率，无进展生存和总生存的影响。对完全反应率来说，疾病分期，NK/T细胞淋巴预后指数（PINK）和初始治疗类型是显着的预后因素。Cox回顾模型分析表明，ECOG表现评分和PINK-EBV DNA（PINK-E）对无进展生存有显着影响。ECOG表现评分和分期对总生存有显着影响。CCRT±CT和CT+RT相比较，两组患者除了诊断时未检测到循环EBV DNA和PINK-E评分外其他临床病理特征相似。在多因素分析和Cox回归模型中，CCRT±CT和CT+RT两组在完全反应率，无进展生存和总生存方面结果均相似。

文章最后认为，对Ⅰ/Ⅱ期NK/T细胞淋巴瘤患者，使用有效的化疗方案时，CCRT和序贯CT+RT结果相似。

原始出处：
Y L Kwong,S J Kim,et al.Sequential chemoterapy/radiotherapy was comparable with concurrent chemoradiotherapy for stage Ⅰ/Ⅱ NK/T-cell lymphoma.ANN ONCOL.January 2018 doi:https://doi.org/10.1093/annonc/mdx684

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    2018-02-12 minlingfeng

    #Oncol#

    0

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    2018-03-03 gongliu

    #NK/T细胞淋巴瘤#

    0

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    2018-11-18 marlenexl

    #细胞淋巴瘤#

    0

  4. 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GetPortalCommentsPageByObjectIdResponse(id=282719, encodeId=8e11282e195d, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Jan 28 00:28:31 CST 2018, time=2018-01-28, status=1, ipAttribution=)]
    2018-02-12 天涯183

    非常好的文章.学习了.很收益

    0

  5. 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GetPortalCommentsPageByObjectIdResponse(id=282719, encodeId=8e11282e195d, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Jan 28 00:28:31 CST 2018, time=2018-01-28, status=1, ipAttribution=)]
    2018-02-04 天涯183

    非常好的文章.学习了

    0

  6. 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GetPortalCommentsPageByObjectIdResponse(id=282719, encodeId=8e11282e195d, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Jan 28 00:28:31 CST 2018, time=2018-01-28, status=1, ipAttribution=)]
    2018-01-30 三生有幸9135

    学习一下谢谢分享

    0

  7. 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    2018-01-29 yzh399

    #放化疗#

    0

  8. 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    2018-01-29 aliceclz

    #T细胞淋巴瘤#

    0

  9. 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    2018-01-28 秀红

    学习了

    0

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href='/topic/show?id=7d2d1802820' target=_blank style='color:#2F92EE;'>#T细胞淋巴瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18028, encryptionId=7d2d1802820, topicName=T细胞淋巴瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfa6343, createdName=aliceclz, createdTime=Mon Jan 29 11:53:00 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282753, encodeId=f7cd282e530d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sun Jan 28 06:31:45 CST 2018, time=2018-01-28, status=1, ipAttribution=), 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    2018-01-28 飛歌

    学习了很有用

    0

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