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J Mycol Med：Fe3O4-NPs与氟康唑相比其抗生物膜的作用

2018-04-01 MedSci MedSci原创

Fe3O4-NPs氟康唑生物膜念珠菌
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生物膜形成能力是导致念珠菌属物种发病的主要致病因素之一。假丝酵母属产生的生物膜可影响治疗效果并增加死亡率。Fe3O4纳米粒子（Fe3O4-NPs）具有磁性和生化特性以及其低成本的特性而成为抗菌的候选者。本研究旨在确定不同假丝酵母菌株的生物膜形成能力以及评估Fe3O4-NPs与FLC相比其抗生物膜作用。 通过MTT比色法测定假丝酵母菌株的生物膜形成能力以及与FLC相比Fe3O4-NPs对假丝酵母菌株

生物膜形成能力是导致念珠菌属物种发病的主要致病因素之一。假丝酵母属产生的生物膜可影响治疗效果并增加死亡率。Fe3O4纳米粒子（Fe3O4-NPs）具有磁性和生化特性以及其低成本的特性而成为抗菌的候选者。本研究旨在确定不同假丝酵母菌株的生物膜形成能力以及评估Fe3O4-NPs与FLC相比其抗生物膜作用。

通过MTT比色法测定假丝酵母菌株的生物膜形成能力以及与FLC相比Fe3O4-NPs对假丝酵母菌株生物膜的抑制作用。

结果显示，鲁希特念珠菌的生物膜形成能力明显高于其他测试的念珠菌菌株。然而，所有研究的念珠菌菌株都可产生生物膜。Fe3O4-NPs在≥1000μg/mL到≥4000μg/mL浓度范围内对不同假丝酵母菌株的生物膜形成有抑制作用，FLC则为≥512μg/mL到≥2048μg/mL。暴露于不同浓度的Fe3O4-NPs后，白色念珠菌和近平滑念珠菌的生物膜形成减少程度高于FLC。尽管这种减少并不明显。Fe3O4-NPs相比，FLC存在下克柔假丝酵母菌、热带假丝酵母和鲁希特念珠菌生物膜形成的减少更加明显（P <0.05）。Fe3O4-NPs和FLC对光滑念珠藻生物膜形成的抑制作用大致相同。

综上所述，该研究结果表明，FLC对克柔假丝酵母菌、热带假丝酵母和鲁希特念珠菌生物膜减少效果在统计学上高于Fe3O4-NPs。

原始出处：

Salari S, Sadat Seddighi N, Ghasemi Nejad Almani P. Evaluation of biofilm formation ability in different Candida strains and anti-biofilm effects of Fe3O4-NPs compared with Fluconazole: an in vitro study. J Mycol Med. 2018 Mar 5. pii: S1156-5233(17)30294-9. doi: 10.1016/j.mycmed.2018.02.007.

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    2019-01-30 ms1756883563247400

    #NPS#

    0

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    2018-04-04 whlxd

    #Fe3O4-NPs#

    0

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    2018-04-12 echonoir

    #抗生物膜#

    0

  4. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301985, encodeId=247530198535, content=了解了解.学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Apr 02 07:39:42 CST 2018, time=2018-04-02, status=1, ipAttribution=)]
    2018-04-03 ms3994565386320060

    #Med#

    0

  5. 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    2018-04-03 yhj-time

    #氟康唑#

    0

  6. 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content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Apr 03 00:07:21 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302000, encodeId=f37430200077, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Apr 02 08:40:58 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301985, encodeId=247530198535, content=了解了解.学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Apr 02 07:39:42 CST 2018, time=2018-04-02, status=1, ipAttribution=)]
    2018-04-03 guihongzh

    #MYC#

    0

  7. 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objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12404, encryptionId=1bbc12404ba, topicName=MYC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Tue Apr 03 14:13:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302196, encodeId=0766302196ae, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Apr 03 00:07:28 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302195, encodeId=2e3a302195f5, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Apr 03 00:07:21 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302000, encodeId=f37430200077, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Apr 02 08:40:58 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301985, encodeId=247530198535, content=了解了解.学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Apr 02 07:39:42 CST 2018, time=2018-04-02, status=1, ipAttribution=)]
    2018-04-03 jihuaijun1112

    学习学习学习

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1689188, encodeId=209b168918814, content=<a href='/topic/show?id=4f5f1301822' target=_blank style='color:#2F92EE;'>#NPS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13018, encryptionId=4f5f1301822, topicName=NPS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=087d28754942, createdName=ms1756883563247400, createdTime=Wed Jan 30 21:13:00 CST 2019, time=2019-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785997, encodeId=69731e85997ed, content=<a href='/topic/show?id=887ae334bc' target=_blank style='color:#2F92EE;'>#Fe3O4-NPs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7334, encryptionId=887ae334bc, topicName=Fe3O4-NPs)], attachment=null, authenticateStatus=null, createdAvatar=, 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objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12404, encryptionId=1bbc12404ba, topicName=MYC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Tue Apr 03 14:13:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302196, encodeId=0766302196ae, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Apr 03 00:07:28 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302195, encodeId=2e3a302195f5, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Apr 03 00:07:21 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302000, encodeId=f37430200077, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Apr 02 08:40:58 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301985, encodeId=247530198535, content=了解了解.学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Apr 02 07:39:42 CST 2018, time=2018-04-02, status=1, ipAttribution=)]
    2018-04-03 jihuaijun1112

    学习学习学习

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1689188, encodeId=209b168918814, content=<a href='/topic/show?id=4f5f1301822' target=_blank style='color:#2F92EE;'>#NPS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13018, encryptionId=4f5f1301822, topicName=NPS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=087d28754942, createdName=ms1756883563247400, createdTime=Wed Jan 30 21:13:00 CST 2019, time=2019-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785997, encodeId=69731e85997ed, content=<a href='/topic/show?id=887ae334bc' target=_blank style='color:#2F92EE;'>#Fe3O4-NPs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7334, encryptionId=887ae334bc, topicName=Fe3O4-NPs)], attachment=null, authenticateStatus=null, createdAvatar=, 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objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12404, encryptionId=1bbc12404ba, topicName=MYC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Tue Apr 03 14:13:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302196, encodeId=0766302196ae, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Apr 03 00:07:28 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302195, encodeId=2e3a302195f5, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Apr 03 00:07:21 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302000, encodeId=f37430200077, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Apr 02 08:40:58 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301985, encodeId=247530198535, content=了解了解.学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Apr 02 07:39:42 CST 2018, time=2018-04-02, status=1, ipAttribution=)]
    2018-04-02 龙胆草

    学习谢谢分享

    0

  10. 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content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Apr 03 00:07:21 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302000, encodeId=f37430200077, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Apr 02 08:40:58 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301985, encodeId=247530198535, content=了解了解.学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Apr 02 07:39:42 CST 2018, time=2018-04-02, status=1, ipAttribution=)]
    2018-04-02 1dd8c52fm63(暂无匿称)

    了解了解.学习学习

    0

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