Int J Cancer:生育年龄和口服避孕药的使用影响卵巢癌的风险

2017-07-31 MedSci MedSci原创

肿瘤

既往的研究发现,增加胎次和使用联合口服避孕药(COC)的持续时间能对卵巢癌提供提供实质性的保护作用。但缺乏生育年龄和COC使用降低卵巢癌风险的足够有效数据。

7月发表在Int J Cancer上的一项研究中,来自美国的研究人员使用美国加州洛杉矶市的相关研究的数据(1632例患者,2340例对照)探究了在首次和末次生育时的年龄和口服避孕药的使用年龄对卵巢癌风险的影响。

调整生育人数后,首次生育的年龄每推迟5年就会使卵巢癌的风险降低13%(95%CI,5% - 21%,P=0.003);35岁后的首次生育者比25岁之前完成首次生育者的卵巢癌风险降低了47%。35岁之前使用COC与更佳的保护作用相关,尤其是与使用COC时年龄较大者。同时考虑先前公布的结果和本研究提出的结果,胎次的增加和较晚的生育年龄是卵巢癌的重要保护因素,并且这个保护时间从末次生育后长达30年,甚至30多年。

本研究中,35岁后使用口服避孕药的保护作用出现了衰减,但它在其它相关研究中并未被观察到,因此,需要对该结果进行进一步的研究。

原始出处:

Wu AH, Pearce CL,et al.Timing of births and oral contraceptive use influences ovarian cancer risk.Int J Cancer. 2017 Jul 27. doi: 10.1002/ijc.30910. [Epub ahead of print]

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    2017-10-31 jyzxjiangqin

    生育年龄和口服避孕药的使用.

    0

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    2017-10-23 jyzxjiangqin

    生育年龄和口服避孕药.

    0

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    2017-09-06 jyzxjiangqin

    生育年龄和口服避孕药的使用.

    0

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    2017-08-02 随梦飞扬

    35岁后的首次生育者比25岁之前完成首次生育者的卵巢癌风险降低了47%

    0

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    2017-08-02 随梦飞扬

    首次生育的年龄每推迟5年就会使卵巢癌的风险降低13%

    0

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    2017-08-02 李东泽

    很好,不错,以后会多学习

    0

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