BMC Pulm Med:血清EMMPRIN的表达或可用于非小细胞肺癌的检测

2018-01-16 MedSci MedSci原创

既往研究表明EMMPRIN过表达涉及肿瘤的恶性生物学行为。本研究旨在揭示EMMPRIN在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达状态及其对NSCLC的诊断价值。 使用免疫组化和酶联免疫吸附试验检测EMMPRIN的表达。通过绘制受试者工作特征(ROC)曲线评估EMMPRIN的临床价值。结果显示,NSCLC组织和血清中EMMPRIN的表达水平高于正常对照

既往研究表明EMMPRIN过表达涉及肿瘤的恶性生物学行为。本研究旨在揭示EMMPRIN在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达状态及其对NSCLC的诊断价值。

使用免疫组化和酶联免疫吸附试验检测EMMPRIN的表达。通过绘制受试者工作特征(ROC)曲线评估EMMPRIN的临床价值。

结果显示,NSCLC组织和血清中EMMPRIN的表达水平高于正常对照组(p <0.05),EMMPRIN的表达与NSCLC的淋巴结转移和晚期分期明显相关(p <0.05)。ROC曲线表明,EMMPRIN用于区分非小细胞肺癌的阈值为80.3 pg/mL,敏感性为97.22%,特异性为95%。血清和组织中EMMPRIN的表达水平较高似乎是NSCLC发生的危险因素(风险比= 1.56和1.1)。

总之,该研究结果表明,EMMPRIN的过度表达与NSCLC的淋巴结转移和晚期相关,血清EMMPRIN的检测有助于NSCLC的诊断

原始出处:

Liu B, Wan Z, et al., Overexpression of EMMPRIN is associated with lymph node metastasis and advanced stage of non-small cell lung cancer: a retrospective study. BMC Pulm Med. 2017 Dec 28;17(1):214. doi: 10.1186/s12890-017-0540-1.

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    2018-01-17 大爰

    学习了谢谢分享!!

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