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NEJM：血浆EBV病毒分析用于早期鼻咽癌筛查

2017-08-10 zhangfan MedSci原创

鼻咽癌EBV早期筛查
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血浆EBV DNA检查是有效的早期鼻咽癌筛查方法，较传统方法确诊率高、病情发现更早、更利于患者的治疗和恢复

循环胞外EBV DNA是鼻咽癌的生物标志物。近日研究人员开展了一项前瞻性研究，考察血浆EB病毒DNA检测在早期无症状鼻咽癌患者中的应用。

研究招募了无症状的早期鼻咽癌风险人群，若患者DNA检测呈阳性，则4周后进行复测，持续的EBV DNA阳性患者进行鼻内镜检查与磁共振成像。

研究总计招募了20174名参与者，其中1112(5.5%)患者首次EBV DNA检测阳性，309人复查结果为阳性(总参与者的1.5%；首次阳性人群的27.8%)。在这309人中，300人进行了内镜检查。275人进行了内镜以及MRI检查，其中34人确诊鼻咽癌。EBV检查对于处于I-II期早期鼻咽癌的确诊率远高于之前的方法(71% vs 20%)并且显著提高了患者的3年无进展生存率(97% vs 70%)。仅1名检查阴性的患者在1年后确诊鼻咽癌。血浆EBV DNA检查对于鼻咽癌诊断的敏感性和特异性分别为97.1%和98.6%。

研究认为，血浆EBV DNA检查是有效的早期鼻咽癌筛查方法，较传统方法确诊率高、病情发现更早、更利于患者的治疗和恢复。

原始出处：

K.C. Allen Chan et al.Analysis of Plasma Epstein–Barr Virus DNA to Screen for Nasopharyngeal Cancer. N Engl J Med，August 10， 2017

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    2017-08-12 随梦飞扬

    血浆EBVDNA检查是有效的早期鼻咽癌筛查方法，较传统方法确诊率高、病情发现更早、更利于患者的治疗和恢复。

    0

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    2017-08-11 zjshifan_98647308

    #EBV#

    0

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    2017-08-10 执着追梦

    学习，谢谢分享

    0

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    2017-08-10 Jackie Li

    学习

    0

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    2017-08-10 xuexin53

    学习

    0

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    2017-08-10 雾夜芭蕾

    研究认为较传统方法这样更有效

    0

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    2017-08-10 1e14ffd0m25(暂无匿称)

    学习学习

    0

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    2017-08-10 雾夜芭蕾

    血浆ebv病毒分析用于鼻咽癌筛查

    0

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    2017-08-10 中医痴

    不错的，学习了，谢谢分享！

    0

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