J Gastroenterology:不同人群肠道微生物群的差异

2019-01-06 MedSci MedSci原创

人肠道微生物群与宿主健康和疾病发展息息相关。对肠道微生物群中与年龄,性别相关的改变的研究十分有限,并且粪便稠度与肠道微生物群之间的关联尚未得到充分研究。因此,本项研究探究了了健康的日本受试者中与年龄,性别和粪便稠度相关的肠道微生物群差异。

背景及目的
肠道微生物群与宿主健康和疾病发展息息相关。对肠道微生物群中与年龄,性别相关的改变的研究十分有限,并且粪便稠度与肠道微生物群之间的关联尚未得到充分研究。因此,本项研究探究了了健康的日本受试者中与年龄,性别和粪便稠度相关的肠道微生物群差异。

方法
本项研究共招募了277名年龄在20-89岁的健康日本受试者,从他们身上获得粪便样品以分析肠道微生物组,同时评估了粪便稠度[布里斯托尔粪便量表(BSS)]与肠道微生物群之间的关系。

结果
尽管男性和女性的微生物结构存在显着差异,但肠道微生物群的α-多样性在男性和女性之间或年龄组之间没有显示出差异。但是普雷沃,Megamonas,梭杆菌,和巨型球菌和双歧杆菌,瘤球菌等菌属在男性和女性存在差异分别。硬粪(BSS类型1和2)的比例在女性中较高; 男性的稀便比例(BSS类型6)较高。男性中的梭杆菌在松散稠度组中明显较高,并且Oscillospira在男性硬稠度组中显着较高; 弯曲杆菌,SMB53和Turicibacter在女性的硬粪组中显着更高。

结论
肠道微生物群的一些变化与年龄和性别有关。粪便稠度和肠道微生物群相关强调了粪便稠度评估对于了解肠功能的重要性。

原始出处:

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    2019-07-02 许安
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    2019-01-06 医者仁心5538

    学习了

    0

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