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AP&T： 长期口服布地奈德治疗微观结肠炎患者的骨质疏松性骨折风险

2020-02-29 不详 MedSci原创

BudesonideOsteoporoticmicroscopiccolitis
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由于口服布地奈德存在首过效应，与其他口服皮质类固醇激素相比，全身生物利用度较低，因此可以避免使用全身性皮质类固醇激素的不良影响。本项研究旨在确定是否使用口服布地奈德会导致微观结肠炎（MC）患者发生骨质疏松性骨折。

背景及目的：
由于口服布地奈德存在首过效应，与其他口服皮质类固醇激素相比，全身生物利用度较低，因此可以避免使用全身性皮质类固醇激素的不良影响。本项研究旨在确定是否使用口服布地奈德会导致微观结肠炎（MC）患者发生骨质疏松性骨折。

方法
研究人员应用来自丹麦全国卫生注册机构的数据进行了一项病例对照研究。研究人员估算了布地奈德使用与骨质疏松性骨折（髋部，腕部和腕部骨折）之间的比值比（OR）。

结果
本项研究确定了417例首次发生骨质疏松性骨折的病例。妇女占86％，中位年龄为78岁。经常使用布地奈德与任何骨质疏松性骨折之间的整体关联的OR均未达到统计学显着性（OR 1.13，CI：0.88-1.47）。脊柱骨折的风险最高（OR 1.98，CI：0.94-4.17），似乎存在剂量反应关系，其次是髋部和腕部骨折（OR 1.17 [CI：0.79-1.73]和OR 0.99 [CI ：0.66-1.47]）。亚组间的OR适度增加，可能是骨折的高风险或低风险（1.00-2.49）。

结论
在微观结肠炎患者中，口服布地奈德与骨质疏松性骨折之间没有统计学关联。布地奈德似乎对脊柱骨折的危险有单独的不利影响，这似乎与剂量有关。

原始出处：

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评论区 (5)
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  1. [GetPortalCommentsPageByObjectIdResponse(id=896301, encodeId=f8ab89630149, content=口服<a href='/topic/show?id=a08a4840288' target=_blank style='color:#2F92EE;'>#布地奈德#</a>与<a href='/topic/show?id=fd3a1018623d' target=_blank style='color:#2F92EE;'>#骨质疏松#</a>性骨折之间没有统计学关联，说明布地奈德与通常的激素相比，是安全的, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48402, encryptionId=a08a4840288, topicName=布地奈德), TopicDto(id=101862, encryptionId=fd3a1018623d, topicName=骨质疏松)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Nov 02 16:43:50 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380009, encodeId=352338000916, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Mon Mar 02 23:35:24 CST 2020, time=2020-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387104, encodeId=1f7b138e104d8, content=<a href='/topic/show?id=df0d101866aa' target=_blank style='color:#2F92EE;'>#骨质疏松性骨折#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101866, encryptionId=df0d101866aa, topicName=骨质疏松性骨折)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Mon Mar 02 03:58:00 CST 2020, time=2020-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390418, encodeId=826213904189d, content=<a href='/topic/show?id=22c6101695c9' target=_blank style='color:#2F92EE;'>#骨折风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101695, encryptionId=22c6101695c9, topicName=骨折风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Mon Mar 02 03:58:00 CST 2020, time=2020-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592617, encodeId=b627159261ebd, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Mon Mar 02 03:58:00 CST 2020, time=2020-03-02, status=1, ipAttribution=)]
    2020-11-02 lovetcm

    口服#布地奈德#与#骨质疏松#性骨折之间没有统计学关联，说明布地奈德与通常的激素相比，是安全的

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=896301, encodeId=f8ab89630149, content=口服<a href='/topic/show?id=a08a4840288' target=_blank style='color:#2F92EE;'>#布地奈德#</a>与<a href='/topic/show?id=fd3a1018623d' target=_blank style='color:#2F92EE;'>#骨质疏松#</a>性骨折之间没有统计学关联，说明布地奈德与通常的激素相比，是安全的, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48402, encryptionId=a08a4840288, topicName=布地奈德), TopicDto(id=101862, encryptionId=fd3a1018623d, topicName=骨质疏松)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Nov 02 16:43:50 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380009, encodeId=352338000916, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Mon Mar 02 23:35:24 CST 2020, time=2020-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387104, encodeId=1f7b138e104d8, content=<a href='/topic/show?id=df0d101866aa' target=_blank style='color:#2F92EE;'>#骨质疏松性骨折#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101866, encryptionId=df0d101866aa, topicName=骨质疏松性骨折)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Mon Mar 02 03:58:00 CST 2020, time=2020-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390418, encodeId=826213904189d, content=<a href='/topic/show?id=22c6101695c9' target=_blank style='color:#2F92EE;'>#骨折风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101695, encryptionId=22c6101695c9, topicName=骨折风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Mon Mar 02 03:58:00 CST 2020, time=2020-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592617, encodeId=b627159261ebd, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Mon Mar 02 03:58:00 CST 2020, time=2020-03-02, status=1, ipAttribution=)]
    2020-03-02 thm112988

    好

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=896301, encodeId=f8ab89630149, content=口服<a href='/topic/show?id=a08a4840288' target=_blank style='color:#2F92EE;'>#布地奈德#</a>与<a href='/topic/show?id=fd3a1018623d' target=_blank style='color:#2F92EE;'>#骨质疏松#</a>性骨折之间没有统计学关联，说明布地奈德与通常的激素相比，是安全的, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48402, encryptionId=a08a4840288, topicName=布地奈德), TopicDto(id=101862, encryptionId=fd3a1018623d, topicName=骨质疏松)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Nov 02 16:43:50 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380009, encodeId=352338000916, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Mon Mar 02 23:35:24 CST 2020, time=2020-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387104, encodeId=1f7b138e104d8, content=<a href='/topic/show?id=df0d101866aa' target=_blank style='color:#2F92EE;'>#骨质疏松性骨折#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101866, encryptionId=df0d101866aa, topicName=骨质疏松性骨折)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Mon Mar 02 03:58:00 CST 2020, time=2020-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390418, encodeId=826213904189d, content=<a href='/topic/show?id=22c6101695c9' target=_blank style='color:#2F92EE;'>#骨折风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101695, encryptionId=22c6101695c9, topicName=骨折风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Mon Mar 02 03:58:00 CST 2020, time=2020-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592617, encodeId=b627159261ebd, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Mon Mar 02 03:58:00 CST 2020, time=2020-03-02, status=1, ipAttribution=)]
    2020-03-02 智慧医人

    #骨质疏松性骨折#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=896301, encodeId=f8ab89630149, content=口服<a href='/topic/show?id=a08a4840288' target=_blank style='color:#2F92EE;'>#布地奈德#</a>与<a href='/topic/show?id=fd3a1018623d' target=_blank style='color:#2F92EE;'>#骨质疏松#</a>性骨折之间没有统计学关联，说明布地奈德与通常的激素相比，是安全的, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48402, encryptionId=a08a4840288, topicName=布地奈德), TopicDto(id=101862, encryptionId=fd3a1018623d, topicName=骨质疏松)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Nov 02 16:43:50 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380009, encodeId=352338000916, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Mon Mar 02 23:35:24 CST 2020, time=2020-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387104, encodeId=1f7b138e104d8, content=<a href='/topic/show?id=df0d101866aa' target=_blank style='color:#2F92EE;'>#骨质疏松性骨折#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101866, encryptionId=df0d101866aa, topicName=骨质疏松性骨折)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Mon Mar 02 03:58:00 CST 2020, time=2020-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390418, encodeId=826213904189d, content=<a href='/topic/show?id=22c6101695c9' target=_blank style='color:#2F92EE;'>#骨折风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101695, encryptionId=22c6101695c9, topicName=骨折风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Mon Mar 02 03:58:00 CST 2020, time=2020-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592617, encodeId=b627159261ebd, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Mon Mar 02 03:58:00 CST 2020, time=2020-03-02, status=1, ipAttribution=)]
    2020-03-02 heli0118

    #骨折风险#

    0

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    2020-03-02 Eleven17

    #骨质#

    0