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Cell Stem Cell：亨廷顿疾病新的治疗策略

2014-06-24 佚名 生物谷

亨廷顿疾病腺病毒
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亨廷顿疾病是一种神经退化疾病，这类疾病的部分特征是纹状体多棘投射神经元减少（MSNs）。Benraiss研究团队在这一疾病的治疗领域获得了突破。他们通过脑室内注射带有BDNF和noggin的腺病毒，发现引发了新纹状体中新神经元的产生。单次脑室内注射AAV4-BDNF和AAV4-noggin腺病毒能引发长期募集新的MSNs，而这种反应不管在野生型小鼠还是亨廷顿动物模型R6/2中都是一致的。直接BD

亨廷顿疾病是一种神经退化疾病，这类疾病的部分特征是纹状体多棘投射神经元减少（MSNs）。Benraiss研究团队在这一疾病的治疗领域获得了突破。

他们通过脑室内注射带有BDNF和noggin的腺病毒，发现引发了新纹状体中新神经元的产生。单次脑室内注射AAV4-BDNF和AAV4-noggin腺病毒能引发长期募集新的MSNs，而这种反应不管在野生型小鼠还是亨廷顿动物模型R6/2中都是一致的。直接BDNF和noggin蛋白处理与脑室内注射AAV4-BDNF和AAV4-noggin腺病毒的结果是一致的，也能活化招募室管膜下前体细胞从而形成新的MSNs，这些细胞进一步成熟整合进入神经环路中。更重要的是，AAV4-BDNF/noggin处理的R6/2 小鼠表现出运动功能衰退得到缓解，存活进一步增加。

在松鼠猴给予脑室内注射BDNF/noggin表现出相似的纹状体神经元的增加，这项研究可能对亨廷顿疾病指出了新的治疗策略。

原始出处：

Benraiss A1, Toner MJ, Xu Q, Bruel-Jungerman E, Rogers EH, Wang F, Economides AN, Davidson BL, Kageyama R, Nedergaard M, Goldman SA.Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease.Cell Stem Cell. 2013 Jun 6;12(6):787-99. doi: 10.1016/j.stem.2013.04.014.

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    2014-08-21 zhaozhouchifen

    #Cell#

    0

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    2014-09-01 hb2008ye

    #stem cell#

    0

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    2015-05-14 维他命

    #CEL#

    0

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    2014-06-26 12498bb3m92(暂无昵称)

    #STEM#

    0

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    2014-06-26 爆笑小医

    #亨廷顿#

    0