Am J Kidney Dis：磷酸钠灌肠剂会导致长期的肾损伤

2016-02-01 Mechront 译 MedSci原创

近期发表在《美国肾病杂志》上的文章表明，磷酸钠灌肠剂的使用会增加长期肾损伤的风险。研究者发现，结肠镜检查前使用磷酸钠灌肠剂（与聚乙二醇比较）会导致长期的eGFR下降，此外非铁缺乏贫血患者eGFR下降的风险更高！Monica Schaefer博士称：“随访的1年时间里，使用磷酸钠灌肠剂的患者肾功下降风险增加38%。”磷酸钠灌肠剂由钠和磷酸盐组成，通过水注入胃肠道中，已用于便秘的治疗和肠道准备。灌肠所

近期发表在《美国肾病杂志》上的文章表明，磷酸钠灌肠剂的使用会增加长期肾损伤的风险。研究者发现，结肠镜检查前使用磷酸钠灌肠剂（与聚乙二醇比较）会导致长期的eGFR下降，此外非铁缺乏贫血患者eGFR下降的风险更高！

Monica Schaefer博士称：“随访的1年时间里，使用磷酸钠灌肠剂的患者肾功下降风险增加38%。”

磷酸钠灌肠剂由钠和磷酸盐组成，通过水注入胃肠道中，已用于便秘的治疗和肠道准备。灌肠所用的磷酸盐有可能被吸收入血液，并可引起血磷水平升高。聚乙二醇溶液是一种电解质溶液。

该研究纳入了70499名50岁以上的参与者，结肠镜检查前参与者使用磷酸钠灌肠剂（伴或不伴聚乙二醇）或单独聚乙二醇进行肠道准备。血清肌酐水平增加50%定义为eGFR下降。

研究结果表明，使用磷酸钠灌肠剂会对患者的肾功造成长期的不良影响，但是确切的机制目前不知道。最初的肾功损伤，可能是由于短暂的高磷血症所致，但持续性的肾损伤机制尚未明确。

原始出处：

Estimated GFR Decline Following Sodium Phosphate Enemas Versus Polyethylene Glycol for Screening Colonoscopy: A Retrospective Cohort Study, Monica Schaefer, PharmD, Emily Littrell, et al. American Journal of Kidney Diseases, doi: 10.1053/j.ajkd.2015.11.018, published online 28 January 2016.

Sodium phosphate enemas increases risk of long-term kidney injury

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2016-04-10 忠诚向上

值得学习

70 0
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2016-04-10 忠诚向上

值得学习

63 0
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2016-04-10 忠诚向上

值得学习

101 0
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2016-04-10 忠诚向上

值得学习

43 0
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2016-04-10 忠诚向上

值得学习

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2016-04-10 忠诚向上

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