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J Periodontal Implant Sci：体外建立牙龈卟啉单胞菌及具核梭杆菌生物膜

2018-04-01 MedSci MedSci原创

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本研究旨在开发和验证标准化的体外病原生物膜附着到唾液涂层表面。将具核梭杆菌和牙龈卟啉单胞菌菌株在厌氧条件下作为单一物种和双物种培养。最初，在24和48小时评估细菌生物量以确定粘附相在涂有唾液的聚苯乙烯表面上的最佳时机。此后，通过结晶紫染色和扫描电子显微镜评估生物膜的发育随时间的变化。结果显示，在单一和双菌株培养条件下，牙龈卟啉单胞菌48小时后总生物量没有明显差异。粘附后，单种和双种生物膜中的牙龈卟

本研究旨在开发和验证标准化的体外病原生物膜附着到唾液涂层表面。将具核梭杆菌和牙龈卟啉单胞菌菌株在厌氧条件下作为单一物种和双物种培养。

最初，在24和48小时评估细菌生物量以确定粘附相在涂有唾液的聚苯乙烯表面上的最佳时机。此后，通过结晶紫染色和扫描电子显微镜评估生物膜的发育随时间的变化。

结果显示，在单一和双菌株培养条件下，牙龈卟啉单胞菌48小时后总生物量没有明显差异。粘附后，单种和双种生物膜中的牙龈卟啉单胞菌培养7天后其生物量明显高于培养3天后的生物量，但是培养5天和7天之间没有明显差异。尽管具核梭杆菌生物膜的生物量在3天时较高，但在培养3、5或7天时没有发现差异。

综上所述，该研究结果表明，孔板中的聚苯乙烯底物作为标准表面，为体外生物膜模型提供可重现的结果。我们的生物膜模型可以作为研究不同表面生物膜研究的参考点。

原始出处：

Tavares LJ, Klein MI, et al., An in vitro model of Fusobacterium nucleatum and Porphyromonas gingivalis in single- and dual-species biofilms. J Periodontal Implant Sci. 2018 Feb 27;48(1):12-21. doi: 10.5051/jpis.2018.48.1.12. eCollection 2018 Feb.

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    2018-08-04 xuyong536

    #MPL#

    0

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    2018-04-10 feather89

    #PE#

    0

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    2019-03-18 bioon1

    #梭杆菌#

    0

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    2019-02-03 xuyu

    #plant#

    0

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    2018-04-03 智慧医人

    #牙龈卟啉单胞菌#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1773201, encodeId=2c781e73201b4, content=<a href='/topic/show?id=5298121e46e' target=_blank style='color:#2F92EE;'>#MPL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12174, encryptionId=5298121e46e, topicName=MPL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10e638510530, createdName=xuyong536, createdTime=Sat Aug 04 15:54:00 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727212, encodeId=20131e2721291, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Apr 10 11:54:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1975763, encodeId=afc119e5763e2, content=<a href='/topic/show?id=6cf1624888e' target=_blank style='color:#2F92EE;'>#梭杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62488, encryptionId=6cf1624888e, topicName=梭杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Mon Mar 18 04:54:00 CST 2019, time=2019-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789174, encodeId=314a1e891745f, content=<a href='/topic/show?id=0c8814344f5' target=_blank style='color:#2F92EE;'>#plant#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14344, encryptionId=0c8814344f5, topicName=plant)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Sun Feb 03 22:54:00 CST 2019, time=2019-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361047, encodeId=64cb136104e90, content=<a href='/topic/show?id=c1006e72663' target=_blank style='color:#2F92EE;'>#牙龈卟啉单胞菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67726, encryptionId=c1006e72663, topicName=牙龈卟啉单胞菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Apr 03 11:54:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301811, encodeId=a7f130181139, content=不错的文章.值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun Apr 01 21:42:44 CST 2018, time=2018-04-01, status=1, ipAttribution=)]
    2018-04-01 1e1b8538m79(暂无匿称)

    不错的文章.值得拥有

    0