Eur Radiol:原发性失眠患者的脑子都在干什么?右侧脑半球脑网络的变化

2017-08-25 shaosai MedSci原创

失眠是指无法入睡或无法保持睡眠状态,导致睡眠不足。又称入睡和维持睡眠障碍(DlMS),为各种原因引起入睡困难、睡眠深度或频度过短、早醒及睡眠时间不足或质量差等,是一种常见病。本研究旨在探究在原发性失眠症患者静息态网络(RSNs)的变化和RSNs与临床表现的关系,并将结果发表在Eur Radiol上。

失眠是指无法入睡或无法保持睡眠状态,导致睡眠不足。又称入睡和维持睡眠障碍(DlMS),为各种原因引起入睡困难、睡眠深度或频度过短、早醒及睡眠时间不足或质量差等,是一种常见病。本研究旨在探究在原发性失眠症患者静息态网络(RSNs)的变化和RSNs与临床表现的关系,并将结果发表在Eur Radiol上。

本研究共纳入了59例原发性失眠症的患者和53名健康志愿者,并行静息态fMRI(rs-MRI)。利用rs-MRI数据的独立成分分析来确定10个RSNs。利用双回归联合FSL随机非参数排列测试进行基于体素分析来分析两组数据的显着性差异。利用Pearson相关分析评价异常功能连接和临床指标的关系。

结果为,原发性失眠症患者在右侧额顶叶网络(FPN)区域出现了连接性下降,包括顶上小叶和顶上回。另外,在右侧颞中回和右枕外侧皮策FPN连接性减低与病程和自述焦虑症具有正性相关。

本研究表明原发性失眠症会出现右侧半球FPN的异常连接,FPN的功能异常于病程和焦虑症状相关。这有助于在静息态脑网络的角度理解原发性失眠症潜在症状的神经基础。

原始出处:

Li S, Tian J, Li M, et al,Altered resting state connectivity in right side frontoparietal network in primary insomnia patients. Eur Radiol. 2017.DOI: 10.1007/s00330-017-5012-8

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    2017-08-26 changjiu

    学习了.谢谢

    0

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    2017-08-25 184****9840

    学习了谢谢分享

    0

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    2017-08-25 1e0f8808m18(暂无匿称)

    失眠痛苦啊.学习了.

    0