BMJ:妊娠早期先兆子痫的临床危险因素分析——Meta分析

2016-04-20 MedSci MedSci原创

本研究旨在通过系统性回顾和荟萃分析确定孕期≤16周女性先兆子痫发生的临床危险因素以帮助临床医生评估孕妇先兆子痫的发生风险。

本研究旨在通过系统性回顾和荟萃分析确定孕期≤16周女性先兆子痫发生的临床危险因素以帮助临床医生评估孕妇先兆子痫的发生风险。

研究人员检索了2000-2015年PubMed 和Embase数据库中相关的文献。纳入标准要求研究中参与者的人数≥1000名,且研究评估了与妊娠≤16周公认的临床危险因素有关的先兆子痫的发生风险。

由两名独立的评审者提取数据。分别计算14个危险因素中每个危险因素相关的先兆子痫的总发生率和总相对风险。

结果共纳入了92项研究,包括25,356,688名孕妇。除了胎儿宫内生长受限外,其他各危险因素的总相对危险度均明显大1。合并抗磷脂抗体综合征的孕妇先兆子痫的总发生率最高。存在先兆子痫既往史的患者先兆子痫的总相对风险最高。其次为慢性高血压,无论是先兆子痫的总发生率还是总相对风险。其他比较密切相关的因素包括孕前糖尿病,孕前体重指数(BMI)大于30和辅助生殖技术的使用。

存在几个临床危险因素(单独或联合)或可用于识别怀孕早期先兆子痫发生风险较高的女性。这些数据可用于制作临床预测模型以用于预测妊娠期孕妇先兆子痫的发生和阿司匹林预防性的使用。

原始出处:

Emily Bartsch, Karyn E Medcalf, et al., Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies. BMJ 2016; 353 doi: http://dx.doi.org/10.1136/bmj.i1753 (Published 19 April 2016)Cite this as: BMJ 2016;353:i1753.

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    2016-05-14 一闲
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    2016-11-04 gaoxiaoe
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    2016-05-29 guojianrong
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    2016-04-26 jjzouyan

    分析合理

    0

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