Semin Arthritis Rheu：柳氮磺吡啶对类风湿性关节炎患者囊虫性肺炎的预防效果

2018-06-21 xiangting MedSci原创

这项巢式病例对照研究结果证实了柳氮磺吡啶对PJP的预防效果。

这项研究旨在评估柳氮磺吡啶对类风湿性关节炎（RA）患者卡氏肺囊虫肺炎（PJP）的预防效果。

研究人员使用日本全国性多中心RA数据库提取了2002年至2014年的数据。为了确定PJP病例，选择住院治疗的PJP患者并验证他们的诊断。通过发病密度取样选择了两个对照组，其中一个不匹配，另一个根据年龄、性别、糖皮质激素、甲氨蝶呤和他克莫司的剂量，和使用生物性疾病改善抗风湿药物（如果使用，类型）进行匹配。通过精确和标准的条件logistic回归估算使用柳氮磺吡啶和其他临床因素相关的PJP优势比。

从18668名参与者中选出60例患者、356例不匹配对照和337例匹配对照。没有1例在PJP发病前使用柳氮磺吡啶。与不匹配对照组比较，显示使用柳氮磺吡啶降低了PJP风险（校正优势比0.18,95％置信区间0.00-0.92）。病例组与匹配对照组比较显示使用柳氮磺吡啶降低PJP的风险（0.08，0.00-0.36）。在对未使用柳氮磺吡啶的病例和不匹配对照进行分析中，PJP风险升高与肺部疾病（3.88,1.89-7.95）和使用糖皮质激素（5.71,2.68-12.19）、甲氨蝶呤（5.25,2.01-13.74）、肿瘤坏死因子抑制剂（2.32,1.10-4.93）相关。

这项巢式病例对照研究结果证实了柳氮磺吡啶对PJP的预防效果。结论有待未来前瞻性研究的确认。

原始出处：

Takahiro Nunokawa, et al. Prophylactic Effect of Sulfasalazine against Pneumocystis Pneumonia in Patients with Rheumatoid Arthritis: A Nested Case-Control Study. Semin Arthritis Rheu. 13 June 2018.

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2022-10-07 showtest

#柳氮磺吡啶#对#类风湿性关节炎#患者#囊虫性肺炎#的预防效果

71 0
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2018-10-19 ms6390871039024434

#Arthritis#

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2018-06-23 lmm397

#关节炎#

29 0
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2018-06-23 ms4964546379600229

#类风湿#

34 0
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2018-06-23 zhaojie88

#ART#

28 0
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2018-06-23 ms1467340776200723

#风湿性关节炎#

37 0
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2018-06-21 changjiu

学习一下谢谢

60 0
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学习了.谢谢分享

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