JACC:三分之一介入患者非罪犯病变有脂质斑块,心血管事件风险翻倍

2017-05-23 许菁 中国循环杂志

近日,哈医大二院于波等在JACC上发表研究称,运用光学相干层析成像(OCT)影像技术发现三成PCI患者的非罪犯病变处有脂质斑块,这类患者严重不良心血管事件风险翻倍。

富含脂质的易损斑块是急性心脏事件的罪魁祸首,存在于非罪犯病变处的易损斑块容易被忽略。

近日,哈医大二院于波等在JACC上发表研究称,运用光学相干层析成像(OCT)影像技术发现三成PCI患者的非罪犯病变处有脂质斑块,这类患者严重不良心血管事件风险翻倍。

研究纳入了6个国家20个中心的1474例PCI患者,均接受了OCT检查靶血管。随访4年。



研究者发现,33.6%的PCI患者的非罪犯血管存在脂质斑块。这类患者4年内严重不良心血管事件发生率显着高于无脂质斑块患者(7.2% vs 2.6%)。



图 非罪犯血管有脂质斑块患者的4年内严重不良心血管事件发生率较高

进一步分析发现,非罪犯血管脂质斑块是非罪犯血管导致严重不良心血管事件的独立危险因素(RR=2.061)。

OCT结果显示,非罪犯血管相关严重不良心血管事件的患者的脂质斑块的脂质长度长、脂质环弧度更宽、最小管腔面积更狭窄。

此外,患者为急性冠脉综合征(RR=2.5)和停用他汀类药物1年以上(RR=4.5)也是严重不良心血管事件的独立预测因素。

原始出处:

Xing L, Higuma T, Wang Z, et al. Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography: A 4-Year Follow-Up Study. J Am Coll Cardiol. 2017, 69: 2502-2513. 

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    2017-10-05 hbwxf
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    2017-05-28 1ddccb01m45(暂无匿称)

    不知道是你抄中华循环杂志,还是循环杂志抄你。但是抄来抄去,连文章研究的人群和目的都翻译错了。这个研究的人群不是限定于急性心梗的人群,其次,是靶血管的非责任病变,而不是非责任血管!这两者定义是不一样的!

    0

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01:57:00 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581583, encodeId=dd8215815833e, content=<a href='/topic/show?id=a12684439ac' target=_blank style='color:#2F92EE;'>#脂质斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84439, encryptionId=a12684439ac, topicName=脂质斑块)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=630f16829020, createdName=12498c32m73暂无昵称, createdTime=Thu May 25 01:57:00 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202100, encodeId=8c0120210016, content=作者请写中国循环杂志, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cb92065739, createdName=qq3586518b, createdTime=Wed May 24 19:14:09 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    2017-05-27 lou.minghong

    学习了

    0

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    2017-05-24 qq3586518b

    作者请写中国循环杂志

    0

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    2017-05-23 daiyaozu

    学习了,不错

    0

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