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Cell Stem Cell：新技术或可加倍不孕不育症疗法的成功率

2016-11-12 佚名 生物谷

不孕不育症
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图片摘自： californiaivf.com 近日，一项发表于国际杂志Cell Stem Cell上的研究报告中，来自美国俄勒冈健康与科学大学和索尔克研究所的研究人员通过研究开发了一种新技术，该技术或许能够帮助治疗不孕不育或严重的线粒体疾病；文章中，研究者指出，他们能够利用正常情况下被浪费掉的遗传物质进行人类卵细胞和卵母细胞的再生，而卵母细胞是胚胎诞生的细胞起源。 这种DNA（

图片摘自： californiaivf.com

近日，一项发表于国际杂志Cell Stem Cell上的研究报告中，来自美国俄勒冈健康与科学大学和索尔克研究所的研究人员通过研究开发了一种新技术，该技术或许能够帮助治疗不孕不育或严重的线粒体疾病；文章中，研究者指出，他们能够利用正常情况下被浪费掉的遗传物质进行人类卵细胞和卵母细胞的再生，而卵母细胞是胚胎诞生的细胞起源。

这种DNA（遗传物质）来自于卵细胞中所形成的的极体，其包含有雌性卵细胞细胞核相同的遗传物质，截止到目前为止，研究者从未利用极体来产生功能性的人类卵细胞用作不孕症治疗，本文研究中，研究者就成功地将女性机体中发育卵母细胞中的极体移植到了去除细胞核的供体机体的卵母细胞细胞质中；尽管当前这种技术未来很多年之后或许才会进入到临床试验，但其对于高龄产妇或许具有一定的意义，最近一项调查显示，在美国女性首次成为母亲的平均年龄从1970年的21.4岁增加到了2006年的25.0岁。

研究者Shoukhrat Mitalipov博士指出，我们都知道随着女性年龄增长其生育能力就会下降，而我们所开发的方法或许能够潜在加倍女性机体中卵细胞的数量，尽管目前我们仅有可能在很有限的一部分细胞中进行检测，但从表观遗传学角度来讲，这种由胚胎细胞衍生的极体的质量看起来还是非常有潜力的。通过对极体进行恢复时期能够简单地“萌芽”形成发育的卵母细胞，研究者们就能够通过核转移来形成和母体相关的额外的遗传性卵细胞，当卵细胞同精子成功融合后，新型的卵母细胞就会发育成为有活力的胚胎。

Hong Ma博士认为，正常情况下在卵细胞发育期间，极体会分裂并且消失，而如今我们对极体进行了再回收利用，我们希望利用这种方法能够加倍患者机体的卵细胞数量以便更好地进行体外受精疗法。这项研究中研究者首次深入调查了人类细胞中极体的活性，同时也阐明了极体能够作为一种新型的遗传物质来源来用作不孕症疗法的开发。

此前研究中，研究者开发了一种线粒体替代疗法，该疗法能够将患者的卵核（或纺锤体）移植到去除原始细胞核的健康供体卵细胞中，同时研究者还证实了这种纺锤体转移技术在猕猴机体中的效果。

原始出处

Hong Ma8, Ryan C. O’Neil8, Nuria Marti Gutierrez, Manoj Hariharan.Functional Human Oocytes Generated by Transfer of Polar Body Genomes.Cell Stem Cell.2016

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    2017-01-21 维他命

    #CEL#

    0

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    2017-07-27 lixiao3326

    #新技术#

    0

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    2016-11-30 zhaozhouchifen

    #Cell#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1959888, encodeId=60da19598888e, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jan 21 04:49:00 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903731, encodeId=6a3f1903e31f6, content=<a href='/topic/show?id=be285836438' target=_blank style='color:#2F92EE;'>#新技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58364, encryptionId=be285836438, topicName=新技术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d39f177, 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encryptionId=82b416e79f5, topicName=stem cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue Nov 15 18:49:00 CST 2016, time=2016-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036549, encodeId=255a20365492a, content=<a href='/topic/show?id=5726203629f' target=_blank style='color:#2F92EE;'>#不孕不育症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20362, encryptionId=5726203629f, topicName=不孕不育症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f5a410, createdName=zxxiang, createdTime=Tue Oct 24 21:49:00 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156249, encodeId=2012156249d5, content=学习…，赞一下！, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Thu Nov 17 07:26:04 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355077, encodeId=d67d13550e7b8, content=<a href='/topic/show?id=b9e02036159' target=_blank style='color:#2F92EE;'>#不孕不育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20361, encryptionId=b9e02036159, topicName=不孕不育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Nov 14 02:49:00 CST 2016, time=2016-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481945, encodeId=ea4314819457d, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Mon Nov 14 02:49:00 CST 2016, time=2016-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155555, encodeId=fcbf155555b8, content=学习了，赞一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Sun Nov 13 23:56:04 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155506, encodeId=4663155506cc, content=期待进一步的研究结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4jbias8haG43qWXQUefZI4aYLDxZjibZYAiba9rD9vuiau7CFDSgcq1v4MXnjic0IIo2LNlLDkpfxQdJA/0, createdBy=512e1971494, createdName=晨曦欲语, createdTime=Sun Nov 13 18:45:45 CST 2016, time=2016-11-13, status=1, ipAttribution=)]
    2016-11-15 hb2008ye

    #stem cell#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1959888, encodeId=60da19598888e, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jan 21 04:49:00 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903731, encodeId=6a3f1903e31f6, content=<a href='/topic/show?id=be285836438' target=_blank style='color:#2F92EE;'>#新技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58364, encryptionId=be285836438, topicName=新技术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d39f177, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Thu Nov 17 07:26:04 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355077, encodeId=d67d13550e7b8, content=<a href='/topic/show?id=b9e02036159' target=_blank style='color:#2F92EE;'>#不孕不育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20361, encryptionId=b9e02036159, topicName=不孕不育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Nov 14 02:49:00 CST 2016, time=2016-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481945, encodeId=ea4314819457d, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Mon Nov 14 02:49:00 CST 2016, time=2016-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155555, encodeId=fcbf155555b8, content=学习了，赞一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Sun Nov 13 23:56:04 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155506, encodeId=4663155506cc, content=期待进一步的研究结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4jbias8haG43qWXQUefZI4aYLDxZjibZYAiba9rD9vuiau7CFDSgcq1v4MXnjic0IIo2LNlLDkpfxQdJA/0, createdBy=512e1971494, createdName=晨曦欲语, createdTime=Sun Nov 13 18:45:45 CST 2016, time=2016-11-13, status=1, ipAttribution=)]
    2017-10-24 zxxiang

    #不孕不育症#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1959888, encodeId=60da19598888e, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jan 21 04:49:00 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903731, encodeId=6a3f1903e31f6, content=<a href='/topic/show?id=be285836438' target=_blank style='color:#2F92EE;'>#新技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58364, encryptionId=be285836438, topicName=新技术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d39f177, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Thu Nov 17 07:26:04 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355077, encodeId=d67d13550e7b8, content=<a href='/topic/show?id=b9e02036159' target=_blank style='color:#2F92EE;'>#不孕不育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20361, encryptionId=b9e02036159, topicName=不孕不育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Nov 14 02:49:00 CST 2016, time=2016-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481945, encodeId=ea4314819457d, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Mon Nov 14 02:49:00 CST 2016, time=2016-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155555, encodeId=fcbf155555b8, content=学习了，赞一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Sun Nov 13 23:56:04 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155506, encodeId=4663155506cc, content=期待进一步的研究结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4jbias8haG43qWXQUefZI4aYLDxZjibZYAiba9rD9vuiau7CFDSgcq1v4MXnjic0IIo2LNlLDkpfxQdJA/0, createdBy=512e1971494, createdName=晨曦欲语, createdTime=Sun Nov 13 18:45:45 CST 2016, time=2016-11-13, status=1, ipAttribution=)]
    2016-11-17 老段

    学习…，赞一下！

    0

  7. 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encryptionId=82b416e79f5, topicName=stem cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue Nov 15 18:49:00 CST 2016, time=2016-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036549, encodeId=255a20365492a, content=<a href='/topic/show?id=5726203629f' target=_blank style='color:#2F92EE;'>#不孕不育症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20362, encryptionId=5726203629f, topicName=不孕不育症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f5a410, createdName=zxxiang, createdTime=Tue Oct 24 21:49:00 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156249, encodeId=2012156249d5, content=学习…，赞一下！, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Thu Nov 17 07:26:04 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355077, encodeId=d67d13550e7b8, content=<a href='/topic/show?id=b9e02036159' target=_blank style='color:#2F92EE;'>#不孕不育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20361, encryptionId=b9e02036159, topicName=不孕不育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Nov 14 02:49:00 CST 2016, time=2016-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481945, encodeId=ea4314819457d, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Mon Nov 14 02:49:00 CST 2016, time=2016-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155555, encodeId=fcbf155555b8, content=学习了，赞一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Sun Nov 13 23:56:04 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155506, encodeId=4663155506cc, content=期待进一步的研究结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4jbias8haG43qWXQUefZI4aYLDxZjibZYAiba9rD9vuiau7CFDSgcq1v4MXnjic0IIo2LNlLDkpfxQdJA/0, createdBy=512e1971494, createdName=晨曦欲语, createdTime=Sun Nov 13 18:45:45 CST 2016, time=2016-11-13, status=1, ipAttribution=)]
    2016-11-14 zhaojie88

    #不孕不育#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1959888, encodeId=60da19598888e, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jan 21 04:49:00 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903731, encodeId=6a3f1903e31f6, content=<a href='/topic/show?id=be285836438' target=_blank style='color:#2F92EE;'>#新技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58364, encryptionId=be285836438, topicName=新技术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d39f177, createdName=lixiao3326, createdTime=Thu Jul 27 15:49:00 CST 2017, time=2017-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869629, encodeId=33e418696292e, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Wed Nov 30 16:49:00 CST 2016, time=2016-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794446, encodeId=8a901e94446a3, content=<a href='/topic/show?id=82b416e79f5' target=_blank style='color:#2F92EE;'>#stem cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16779, encryptionId=82b416e79f5, topicName=stem cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue Nov 15 18:49:00 CST 2016, time=2016-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036549, encodeId=255a20365492a, content=<a href='/topic/show?id=5726203629f' target=_blank style='color:#2F92EE;'>#不孕不育症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20362, encryptionId=5726203629f, topicName=不孕不育症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f5a410, createdName=zxxiang, createdTime=Tue Oct 24 21:49:00 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156249, encodeId=2012156249d5, content=学习…，赞一下！, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Thu Nov 17 07:26:04 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355077, encodeId=d67d13550e7b8, content=<a href='/topic/show?id=b9e02036159' target=_blank style='color:#2F92EE;'>#不孕不育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20361, encryptionId=b9e02036159, topicName=不孕不育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Nov 14 02:49:00 CST 2016, time=2016-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481945, encodeId=ea4314819457d, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Mon Nov 14 02:49:00 CST 2016, time=2016-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155555, encodeId=fcbf155555b8, content=学习了，赞一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Sun Nov 13 23:56:04 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155506, encodeId=4663155506cc, content=期待进一步的研究结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4jbias8haG43qWXQUefZI4aYLDxZjibZYAiba9rD9vuiau7CFDSgcq1v4MXnjic0IIo2LNlLDkpfxQdJA/0, createdBy=512e1971494, createdName=晨曦欲语, createdTime=Sun Nov 13 18:45:45 CST 2016, time=2016-11-13, status=1, ipAttribution=)]
    2016-11-14 12498bb3m92(暂无昵称)

    #STEM#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1959888, encodeId=60da19598888e, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jan 21 04:49:00 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903731, encodeId=6a3f1903e31f6, content=<a href='/topic/show?id=be285836438' target=_blank style='color:#2F92EE;'>#新技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58364, encryptionId=be285836438, topicName=新技术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d39f177, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Thu Nov 17 07:26:04 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355077, encodeId=d67d13550e7b8, content=<a href='/topic/show?id=b9e02036159' target=_blank style='color:#2F92EE;'>#不孕不育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20361, encryptionId=b9e02036159, topicName=不孕不育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Nov 14 02:49:00 CST 2016, time=2016-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481945, encodeId=ea4314819457d, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Mon Nov 14 02:49:00 CST 2016, time=2016-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155555, encodeId=fcbf155555b8, content=学习了，赞一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Sun Nov 13 23:56:04 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155506, encodeId=4663155506cc, content=期待进一步的研究结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4jbias8haG43qWXQUefZI4aYLDxZjibZYAiba9rD9vuiau7CFDSgcq1v4MXnjic0IIo2LNlLDkpfxQdJA/0, createdBy=512e1971494, createdName=晨曦欲语, createdTime=Sun Nov 13 18:45:45 CST 2016, time=2016-11-13, status=1, ipAttribution=)]
    2016-11-13 老段

    学习了，赞一下

    0

  10. 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encryptionId=82b416e79f5, topicName=stem cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue Nov 15 18:49:00 CST 2016, time=2016-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036549, encodeId=255a20365492a, content=<a href='/topic/show?id=5726203629f' target=_blank style='color:#2F92EE;'>#不孕不育症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20362, encryptionId=5726203629f, topicName=不孕不育症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f5a410, createdName=zxxiang, createdTime=Tue Oct 24 21:49:00 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156249, encodeId=2012156249d5, content=学习…，赞一下！, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Thu Nov 17 07:26:04 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355077, encodeId=d67d13550e7b8, content=<a href='/topic/show?id=b9e02036159' target=_blank style='color:#2F92EE;'>#不孕不育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20361, encryptionId=b9e02036159, topicName=不孕不育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Nov 14 02:49:00 CST 2016, time=2016-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481945, encodeId=ea4314819457d, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Mon Nov 14 02:49:00 CST 2016, time=2016-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155555, encodeId=fcbf155555b8, content=学习了，赞一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Sun Nov 13 23:56:04 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155506, encodeId=4663155506cc, content=期待进一步的研究结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4jbias8haG43qWXQUefZI4aYLDxZjibZYAiba9rD9vuiau7CFDSgcq1v4MXnjic0IIo2LNlLDkpfxQdJA/0, createdBy=512e1971494, createdName=晨曦欲语, createdTime=Sun Nov 13 18:45:45 CST 2016, time=2016-11-13, status=1, ipAttribution=)]
    2016-11-13 晨曦欲语

    期待进一步的研究结果

    0

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