Yeungnam Univ J Med:口服强力霉素是否会影响耐万古霉素肠球菌的根除?

2020-02-20 不详 网络

耐万古霉素肠球菌(VRE)在医院感染中尤其是在尿液样本中更为常见。但是,到目前为止,还没有任何治疗方案能够有效根除尿液VRE的定植。因此,为了评估强力霉素在消除尿液VRE和缩短VRE分离期方面的功效,我们比较了强力霉素治疗和未治疗患者之间的VRE菌落检测期。2011年1月至2018年2月,在三级学术医院进行了83例尿培养中VRE菌落定植患者的回顾性队列研究。Kaplan-Meier生存分析用于评估

耐万古霉素肠球菌(VRE)在医院感染中尤其是在尿液样本中更为常见。但是,到目前为止,还没有任何治疗方案能够有效根除尿液VRE的定植。因此,为了评估强力霉素在消除尿液VRE和缩短VRE分离期方面的功效,我们比较了强力霉素治疗和未治疗患者之间的VRE菌落检测期。

2011年1月至2018年2月,在三级学术医院进行了83例尿培养中VRE菌落定植患者的回顾性队列研究。Kaplan-Meier生存分析用于评估治疗组和非治疗组的根除率。通过多元逻辑回归分析分析了影响尿液VRE定植持续性的因素。

结果显示,强力霉素治疗组(90.5%)在整个住院期间的VRE总清除率高于未治疗组(58.1%,p = 0.014)。生存分析显示,强力霉素治疗组的5、10和20天累积根除率分别为78.3%,100%和100%,非治疗组分别为18.5%,45.7%和67.8%。分别表明多西环素治疗组的根除率高于非治疗组(p <0.001)。在多因素logistic回归分析中,仅显示强力霉素治疗会影响尿液VRE定植持续性。

综上所述,该研究结果表明,强力霉素的治疗提高了尿液VRE定植的根除率,似乎有助于缩短VRE分离期。

原始出处:

Kim Y, Bae S, et al., Does oral doxycycline treatment affect eradication of urine vancomycin-resistant Enterococcus? A tertiary hospital study. Yeungnam Univ J Med. 2020 Feb 18. doi: 10.12701/yujm.2019.00430.

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    2020-02-22 风铃830
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    2020-05-21 tamgche
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