Diabetes Care：糖尿病前期是周围神经病变独立高危因素

2015-05-12 MedSci MedSci原创

研究目的：越来越多的证据表明，周围神经病变开始于糖尿病发病的早期阶段。本研究旨在，在存在T2DM发生风险的人群中，根据糖耐量和代谢综合征水平，评估周围神经病变的患病率及与之相关的神经系统的变化。研究设计与方法：我们选择467名受试者进行纵向的队列研究，评估受试者的新陈代谢水平和胰腺细胞功能。使用密歇根神经病变筛查工具（MNSI）(及其)分数（>2）来定义周围神经病变，同时使用客观的振

研究目的：越来越多的证据表明，周围神经病变开始于糖尿病发病的早期阶段。本研究旨在，在存在T2DM发生风险的人群中，根据糖耐量和代谢综合征水平，评估周围神经病变的患病率及与之相关的神经系统的变化。

研究设计与方法：我们选择467名受试者进行纵向的队列研究，评估受试者的新陈代谢水平和胰腺细胞功能。使用密歇根神经病变筛查工具（MNSI）(及其)分数（>2）来定义周围神经病变，同时使用客观的振动感觉阈值（VPT）来评估神经紊乱的严重性。使用IDF/AHA的标准，定义代谢综合征。

结果：从正常糖耐量、糖尿病前期到新发糖尿病，周围神经病变的发病率依次是：29%,
49%和 50%，平均的VPT是正常糖耐量：6.5 V；糖尿病前期：7.9 V；新发糖尿病是：7.6 V.糖尿病前期。与正常糖耐量相比，糖尿病前期与高MNSI评分和VPT评分相关。此外，进行性的葡萄糖耐受不良3年提示存在高风险的周围神经病变(P = 0.007)和神经功能紊乱(P = 0.002)。而代谢综合征与MNSI评分和VPTs并不独立相关。

结论：在合并多种糖尿病风险的个体中，糖尿病前期与新发的糖尿病，有相似的周围神经病变和严重的神经功能紊乱风险。糖尿病前期，而不是代谢综合征，与周围神经病变和严重的神经功能紊乱的发生呈独立相关性。

原始出处：

Lee C, Perkins B, Kayaniyil S, et al. Peripheral Neuropathy and Nerve Dysfunction in Individuals atHigh Risk for Type 2 Diabetes: The PROMISE Cohort[J]. Diabetes care, 2015,38(5): 793-800.

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2016-01-21 木头人513

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2015-10-27 ms5439512287675881

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2015-12-31 Smile2692

#周围神经#

32 0
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2016-04-27 ms9608593228839890

#DIA#

31 0
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2015-06-16 dreamslink

赞

63 0
[GetPortalCommentsPageByObjectIdResponse(id=1901290, encodeId=4ac01901290c3, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Thu Jan 21 09:01:00 CST 2016, time=2016-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759556, encodeId=21ce1e595567b, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Oct 27 14:01:00 CST 2015, time=2015-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748236, encodeId=03011e48236e1, content=<a href='/topic/show?id=15b33952464' target=_blank style='color:#2F92EE;'>#周围神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39524, encryptionId=15b33952464, topicName=周围神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f00136108751, createdName=Smile2692, createdTime=Thu Dec 31 02:01:00 CST 2015, time=2015-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637103, encodeId=77f0163e1030a, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Apr 27 11:01:00 CST 2016, time=2016-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27762, encodeId=fd792e762e1, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKT7Exm9wh9wsVDUxNuicyfcsIlwSMQjeu0bnzjBBXuXgCq0GxthROPNEmfhfLpCZC3qDjpSK7LeyA/132, createdBy=67811617930, createdName=dreamslink, createdTime=Tue Jun 16 11:22:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24411, encodeId=a72b24411a6, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b64e106775, createdName=cement123, createdTime=Thu May 21 13:25:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491229, encodeId=4c6414912296c, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Thu May 14 12:01:00 CST 2015, time=2015-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500324, encodeId=5ddd150032435, content=<a href='/topic/show?id=ecdfe438970' target=_blank style='color:#2F92EE;'>#神经病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74389, encryptionId=ecdfe438970, topicName=神经病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ea69427176, createdName=lingaifan, createdTime=Thu May 14 12:01:00 CST 2015, time=2015-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23341, encodeId=b92d233416b, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed May 13 20:22:00 CST 2015, time=2015-05-13, status=1, ipAttribution=)]
2015-05-21 cement123

赞

66 0
[GetPortalCommentsPageByObjectIdResponse(id=1901290, encodeId=4ac01901290c3, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Thu Jan 21 09:01:00 CST 2016, time=2016-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759556, encodeId=21ce1e595567b, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Oct 27 14:01:00 CST 2015, time=2015-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748236, encodeId=03011e48236e1, content=<a href='/topic/show?id=15b33952464' target=_blank style='color:#2F92EE;'>#周围神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39524, encryptionId=15b33952464, topicName=周围神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f00136108751, createdName=Smile2692, createdTime=Thu Dec 31 02:01:00 CST 2015, time=2015-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637103, encodeId=77f0163e1030a, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Apr 27 11:01:00 CST 2016, time=2016-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27762, encodeId=fd792e762e1, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKT7Exm9wh9wsVDUxNuicyfcsIlwSMQjeu0bnzjBBXuXgCq0GxthROPNEmfhfLpCZC3qDjpSK7LeyA/132, createdBy=67811617930, createdName=dreamslink, createdTime=Tue Jun 16 11:22:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24411, encodeId=a72b24411a6, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b64e106775, createdName=cement123, createdTime=Thu May 21 13:25:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491229, encodeId=4c6414912296c, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Thu May 14 12:01:00 CST 2015, time=2015-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500324, encodeId=5ddd150032435, content=<a href='/topic/show?id=ecdfe438970' target=_blank style='color:#2F92EE;'>#神经病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74389, encryptionId=ecdfe438970, topicName=神经病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ea69427176, createdName=lingaifan, createdTime=Thu May 14 12:01:00 CST 2015, time=2015-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23341, encodeId=b92d233416b, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed May 13 20:22:00 CST 2015, time=2015-05-13, status=1, ipAttribution=)]
2015-05-14 axin012

#神经病#

38 0
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2015-05-14 lingaifan

#神经病变#

28 0
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2015-05-13 huaxipanxing

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Diabetes Care：糖尿病前期是周围神经病变独立高危因素

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