Diabetes :在减重试验中,减肥过程中的睡眠障碍、能量摄入和身体合成的变化。

2022-03-12 从医路漫漫 MedSci原创

为了研究睡眠障碍与体重和身体组成变化之间的关系,以及食欲和食物渴望变化在减肥2年减肥饮食干预试验中的中介作用,这项研究包括810名基线睡眠障碍评估的超重或肥胖个体。

目的:为了研究睡眠障碍与体重和身体组成变化之间的关系,以及食欲和食物渴望变化在减肥2年减肥饮食干预试验中的中介作用,这项研究包括810名基线睡眠障碍评估的超重或肥胖个体,他们被随机分配到四种饮食中的一种,饮食中的大量营养成分各不相同。在2年的干预期间,通过双x线骨密度仪(DXA)和计算机断层扫描(CT)评估体重和脂肪分布的变化。参与者被要求提供基线时的睡眠障碍水平(无、轻微、中度或重度),并回忆自上次访问以来6个月、12个月、18个月和24个月的睡眠障碍情况。

结果:最初6个月的体重减轻,随后1.5年体重稳步反弹。多变量调整后,从基线到6个月睡眠障碍更严重的参与者在6个月时体重(P趋势< 0.001)和腰围(P趋势= 0.002)显著下降。相比之下,个人不睡眠障碍从基线到6个月,那些轻微的,温和,或者伟大的睡眠障碍显示减肥失败的风险升高(-5%或更多损失)在6个月,最大体重达到时,或为1.24 (95% CI 0.87, 1.78), 1.27 (95% CI 0.75,2.13)和3.12 (95% CI分别为1.61和6.03)。此外,我们观察到,2年多来反复测量的睡眠障碍水平与总体减肥率(每6个月的体重变化)呈负相关(P趋势< 0.001)。此外,从基线到6个月的体重减轻期间的睡眠障碍和从6个月到24个月的体重恢复期间的总脂肪、总脂肪质量百分比和躯干脂肪百分比在2年内的变化具有显著的预测性。我们的结果还表明,对碳水化合物/淀粉、快餐脂肪、甜食的渴望;渴望,预期消费,食欲测量的饥饿感。在6个月时测量的饮食克制、去抑制和饥饿分量表显著调节了睡眠障碍对体重减轻的影响。

表1 810名睡眠障碍基线评估2年以上参与者的遗漏模式

表2 根据睡眠障碍,肥胖测量和能量消耗从基线到6个月和从6个月到24个月的总体变化(Δ)

表3 使用新的睡眠障碍类别(n=648)分别考虑0-6个月的每个调节因素后的减肥结果(n=648)

结论:在减肥过程中,更严重的睡眠障碍与饮食干预过程中减肥失败的风险增加有关。对食物的渴望和饮食行为可能在一定程度上调节了这些联系。

原文出处: Li A,  Li X,  Zhou T,et al.Sleep Disturbance, Changes in Energy Intake and Body Compositing During Weight Loss in the POUNDS LOST Trial.:Diabetes 2022 Feb 24

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