J Dent Res:牙周炎、颈动脉钙化动脉瘤与心肌梗死风险的关系

2020-12-07 MedSci原创 MedSci原创

心血管疾病是一种常见的疾病,也是导致患者过早死亡的常见原因。如果能及早发现危险因素,心血管疾病是可以预防的。影像学检查发现颈动脉钙化动脉瘤(CCAA)和牙周炎都与心血管疾病风险增加有关。一项病例对照研

血管疾病是一种常见的疾病,也是导致患者过早死亡的常见原因。如果能及早发现危险因素,心血管疾病是可以预防的。影像学检查发现颈动脉钙化动脉瘤(CCAA)和牙周炎都与心血管疾病风险增加有关。一项病例对照研究旨在:1)调查X线显示的牙周炎和CCAA之间的关联,2)确定CCAA合并牙周炎导致未来心肌梗死的风险,研究结果已在线发表于J Dent Res。

研究人员从PAROKRANK研究中招募了1,482名患有牙周炎和CCAA的参与者(738例患者和744名对照者)。参与者接受了包括颈动脉区域在内的全景X光片检查。在696例患者和696名年龄、性别和居住区匹配的对照组中,研究人员评估了心肌梗死和牙周炎与CCAA之间的关系。对牙周炎进行了放射学评估(骨质丧失程度)和临床牙周病指数评分(来自临床和放射学评估)。

 

结果显示,CCAA和临床牙周病指数评分在病例组(OR,1.51;95% CI,1.09~2.10;P = 0.02)和对照组(OR,1.70;95% CI,1.22~2.38;P <0.01)之间存在关联,尽管CCAA和骨质丧失程度之间没有关联。多变量分析结果显示,心肌梗死与CCAA合并牙周炎相关,由骨质流失程度可以看出(OR,1.75;95% CI,1.11~2.74;P = 0.01)。按性别对队列进行分层时,只有男性在心肌梗死和CCAA合并牙周炎之间显示出显著的关联。临床诊断为牙周炎的参与者比非牙周炎参与者在全景X线片中更多地表现出CCAA,无论近期是否存在心肌梗死。合并牙周炎和CCAA的参与者与单独患有其中一种情况的参与者相比,心肌梗死的风险更高。

 

综上所述,这些研究结果表明,牙科护理中的患者可能会从牙医评估CCAA的全景X光片中受益--尤其是没有接受过任何心血管疾病预防措施的牙周炎患者。

 

原始出处:

 

N Gustafsson, J Ahlqvist, et al., Associations among Periodontitis, Calcified Carotid Artery Atheromas, and Risk of Myocardial Infarction. J Dent Res. 2020 Jan;99(1):60-68. doi: 10.1177/0022034519885362.

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