Gastroenterology:IBD患者在急诊手术的术后死亡率更高

2015-10-23 徐媛 MedSci原创

在紧急肠道切除术后,对于炎症性肠病的发生研究报道不同。本研究以人群为基础进行了一项系统回顾和荟萃分析来确定肠道切除术后IBD患者术后死亡率。研究人员在Medline、EMBASE,PubMed等数据库检索了从1990年到2015年的相关研究报告,并选定了来自15个国家相关IBD患者术后死亡率的18篇文章和3篇报告的摘要,其中包括67057例溃疡性结肠炎(UC)患者和75971例克罗恩病(CD)。这

在紧急肠道切除术后,对于炎症性肠病的发生研究报道不同。本研究以人群为基础进行了一项系统回顾和荟萃分析来确定肠道切除术后IBD患者术后死亡率。

研究人员在Medline、EMBASE,PubMed等数据库检索了从1990年到2015年的相关研究报告,并选定了来自15个国家相关IBD患者术后死亡率的18篇文章和3篇报告的摘要,其中包括67057例溃疡性结肠炎(UC)患者和75971例克罗恩病(CD)。这些数据根据时间,地理位置,和选择性 vs 急诊手术病例进行了分层。

在UC患者中,选择性手术的术后死亡率(0.7%,95% [CI],0.6% - -0.9%)相比于急诊手术(5.3%;95% [CI],95% 5.3%)显著降低。在CD患者中,选择性手术的术后死亡率(0.6%; 95% CI, 0.2%-1.7%) 相比于急诊手术的术后死亡率高(3.6%; 95% CI, 1.8%-6.9%)显著降低。以上结果显示,在UC和CD患者中,选择性手术的术后死亡率(P = 0.78)和急诊手术的术后死亡率(P = 0.31) 并没有什么不同。研究人员对数据分层时,发现CD患者随着时间推移其术后死亡率降低(P<0.05),但是UC患者的死亡率没有变化(P=0.21)。

在这项系统性综述和荟萃分析的基础上,急诊手术的术后死亡率高,医生应优化管理策略以避免紧急手术,同时进行相关必要研究从而得出更有效的治疗方式。

原始出处

Singh S1, Al-Darmaki A1, Frolkis AD2, Seow CH3, Leung Y3, Novak KL3, Ghosh S3, Eksteen B3, Panaccione R3, Kaplan GG4.Postoperative Mortality Among Patients With Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis of Population-Based Studies.Gastroenterology. 2015 Oct;

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    2016-07-17 许安
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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41060, encodeId=9dd5410605c, content=收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2be01625436, createdName=fatalmelanie, createdTime=Sun Oct 25 13:37:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263416, encodeId=910d126341601, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Sun Oct 25 06:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504207, encodeId=e48b150420e7d, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Sun Oct 25 06:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556255, encodeId=7fd21556255e9, content=<a href='/topic/show?id=c7aa5256ee6' target=_blank style='color:#2F92EE;'>#急诊手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52567, encryptionId=c7aa5256ee6, topicName=急诊手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f43414728556, createdName=chenhongpeng, createdTime=Sun Oct 25 06:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=)]
    2015-12-30 xyfg98

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1710816, encodeId=320e1e108161b, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Thu Apr 07 20:39:00 CST 2016, time=2016-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071589, encodeId=cb4520e158912, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41060, encodeId=9dd5410605c, content=收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2be01625436, createdName=fatalmelanie, createdTime=Sun Oct 25 13:37:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263416, encodeId=910d126341601, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Sun Oct 25 06:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504207, encodeId=e48b150420e7d, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Sun Oct 25 06:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556255, encodeId=7fd21556255e9, content=<a href='/topic/show?id=c7aa5256ee6' target=_blank style='color:#2F92EE;'>#急诊手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52567, encryptionId=c7aa5256ee6, topicName=急诊手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f43414728556, createdName=chenhongpeng, createdTime=Sun Oct 25 06:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=)]
    2015-10-27 fengzhigu

    好吧

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1710816, encodeId=320e1e108161b, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Thu Apr 07 20:39:00 CST 2016, time=2016-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071589, encodeId=cb4520e158912, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41060, encodeId=9dd5410605c, content=收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2be01625436, createdName=fatalmelanie, createdTime=Sun Oct 25 13:37:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263416, encodeId=910d126341601, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Sun Oct 25 06:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504207, encodeId=e48b150420e7d, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Sun Oct 25 06:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556255, encodeId=7fd21556255e9, content=<a href='/topic/show?id=c7aa5256ee6' target=_blank style='color:#2F92EE;'>#急诊手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52567, encryptionId=c7aa5256ee6, topicName=急诊手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f43414728556, createdName=chenhongpeng, createdTime=Sun Oct 25 06:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=)]
    2015-10-25 owlhealth

    不错,看看

    0

  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41060, encodeId=9dd5410605c, content=收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2be01625436, createdName=fatalmelanie, createdTime=Sun Oct 25 13:37:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263416, encodeId=910d126341601, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Sun Oct 25 06:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504207, encodeId=e48b150420e7d, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Sun Oct 25 06:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556255, encodeId=7fd21556255e9, content=<a href='/topic/show?id=c7aa5256ee6' target=_blank style='color:#2F92EE;'>#急诊手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52567, encryptionId=c7aa5256ee6, topicName=急诊手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f43414728556, createdName=chenhongpeng, createdTime=Sun Oct 25 06:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=)]
    2015-10-25 fatalmelanie

    收藏

    0

  8. 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createdName=xyfg98, createdTime=Wed Dec 30 12:48:00 CST 2015, time=2015-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41465, encodeId=48124146544, content=好吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150904/IMG55E8DB68F05883098.jpg, createdBy=e00a1631985, createdName=fengzhigu, createdTime=Tue Oct 27 08:21:00 CST 2015, time=2015-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41114, encodeId=e33f411143b, content=不错,看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Sun Oct 25 16:24:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41060, encodeId=9dd5410605c, content=收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2be01625436, createdName=fatalmelanie, createdTime=Sun Oct 25 13:37:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263416, encodeId=910d126341601, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Sun Oct 25 06:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504207, encodeId=e48b150420e7d, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Sun Oct 25 06:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556255, encodeId=7fd21556255e9, content=<a href='/topic/show?id=c7aa5256ee6' target=_blank style='color:#2F92EE;'>#急诊手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52567, encryptionId=c7aa5256ee6, topicName=急诊手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f43414728556, createdName=chenhongpeng, createdTime=Sun Oct 25 06:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=)]
    2015-10-25 bnurmamat
  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41060, encodeId=9dd5410605c, content=收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2be01625436, createdName=fatalmelanie, createdTime=Sun Oct 25 13:37:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263416, encodeId=910d126341601, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Sun Oct 25 06:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), 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createdAvatar=null, createdBy=f43414728556, createdName=chenhongpeng, createdTime=Sun Oct 25 06:39:00 CST 2015, time=2015-10-25, status=1, ipAttribution=)]
  10. 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