Pediatrics:新生儿出院前进行彻底的风险评估非常重要

2015-11-30 徐媛 MedSci原创

在出新生儿出院之前,应该对可能发生的严重高胆红素血症的危险因素进行评估。研究人员确定了足月儿的高胆红素血(妊娠年龄≥37周)相关风险因素以及对母亲和围产期相关风险因素进行了分析,进而形成一个个性化的临床使用的风险评估工具。 本研究以人群为基础,收纳了来自于1999年到2012年瑞典医出生登记的数据,共收纳了1261948名新生儿。其中23711名新生儿被诊断为高胆红素血症,排除溶血性疾病的新生儿

在出新生儿出院之前,应该对可能发生的严重高胆红素血症的危险因素进行评估。研究人员确定了足月儿的高胆红素血(妊娠年龄≥37周)相关风险因素以及对母亲和围产期相关风险因素进行了分析,进而形成一个个性化的临床使用的风险评估工具。

本研究以人群为基础,收纳了来自于1999年到2012年瑞典医出生登记的数据,共收纳了1261948名新生儿。其中23711名新生儿被诊断为高胆红素血症,排除溶血性疾病的新生儿,对非溶血性黄疸的危险因素进行预测。

新生儿高胆红素血≥1.5(中型效应或更多)的风险因素有妊娠年龄37-38周(调整优势比aOR = 2.83),亚裔母亲(优势比= 2.09),初产妇(aOR = 2.06),胎龄较大的婴儿(优势比=1.84),母亲超重或肥胖(优势比=1.83),胎龄较小的婴儿(优势比= 1.66)。剖宫产风险降低(aOR = 0.45)。而在适于胎龄儿、无引产的阴道分娩、胎龄39~41周出生,非亚裔、非肥胖的经产母亲,新生儿非溶血性高胆红素血症的发生率仅为0.7%。与不同风险因素相比,新生儿发生高胆红素血的风险比例在0.2%到25%不等。

在对新生儿出院前进行胆红素水平的风险评估中,收集母亲及孕产期相关信息非常重要。较高的胆红素水平可能引起的脑神经系统的损害。因此,在所有新生儿出院前进行彻底的风险评估显得极其重要。

原始出处

Norman M1, ?berg K2, Holmsten K3, Weibel V4, Ekéus C2.Predicting Nonhemolytic Neonatal Hyperbilirubinemia.Pediatrics. 2015 Nov 9.

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    2016-02-21 智智灵药
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    2016-09-05 hbwxf
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    2015-12-01 dearluodi

    有意思

    0

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    2015-11-30 lyh994

    形成出院常规呗

    0

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