Eur Radiol:肝细胞肝癌肝癌切除术后肝衰竭怎么诊断?列线图的个体化预测价值!

2017-08-14 shaosai MedSci原创

肝衰竭是多种因素引起的严重肝脏损害,导致其合成、解毒、排泄和生物转化等功能发生严重障碍或失代偿,出现以凝血机制障碍和黄疸、肝性脑病、腹水等为主要表现的一组临床症候群。分为急性肝衰竭、亚急性肝衰竭、慢加急性(亚急性)肝衰竭和慢性肝衰竭四大类。临床表现为极度乏力,并有明显厌食、腹胀、恶心、呕吐等严重消化道症状。本研究为了提高列线图对预测可切除肝细胞肝癌(HCC)患者发生肝癌切除术后肝衰竭(PHLF)的

肝衰竭是多种因素引起的严重肝脏损害,导致其合成、解毒、排泄和生物转化等功能发生严重障碍或失代偿,出现以凝血机制障碍和黄疸、肝性脑病、腹水等为主要表现的一组临床症候群。分为急性肝衰竭、亚急性肝衰竭、慢加急性(亚急性)肝衰竭和慢性肝衰竭四大类。临床表现为极度乏力,并有明显厌食、腹胀、恶心、呕吐等严重消化道症状。本研究为了提高列线图对预测可切除肝细胞肝癌(HCC)患者发生肝癌切除术后肝衰竭(PHLF)的临床应用价值,并将结果发表在Eur Radiol上。列线图来自于2015.01-2015.12的136例可切除HCC并行肝癌切除术的患者数据。另有80例患者作为内部验证数据。利用一致性指数(C-index)、校准曲线来验证列线图的预测准确率和鉴别能力,并与常规预测手段相比。结果为PHLF发生在30.9%的患者中,包括36例A级和6例B级肝癌患者。列线图是在血小板计数、血清胆红素、血清GGT、门脉高压和剪切波弹性摄影的临床体征的基础之上,具有很好的校准和辨别能力,C-indice为0.85。该模型在独立内部验证组表现出令人满意的拟合优度和鉴别能力,PHLF 的C-indices 为0.824。这

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  1. 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time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863292, encodeId=4d20186329208, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Thu Feb 01 15:23:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234327, encodeId=10ab23432e35, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, 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    2018-06-07 攻城掠地

    谢谢了.谢谢分享

    0

  2. 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    2018-06-07 攻城掠地

    学习了

    0

  3. 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createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Aug 16 12:23:00 CST 2017, time=2017-08-16, status=1, ipAttribution=)]
    2018-04-01 仁医小青年

    学习了

    0

  4. 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  5. 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  6. 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  7. 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    2018-02-01 xjy02
  8. 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    2017-08-17 大爰

    学习了谢谢分享!!

    0

  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Aug 16 12:23:00 CST 2017, time=2017-08-16, status=1, ipAttribution=)]
    2017-08-16 衣带渐宽

    学习

    0

  10. 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