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Colloids Surf B Biointerfaces：GO@Au纳米棒用于化学-光热治疗和阿霉素的释放

2018-02-28 MedSci MedSci原创

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氧化石墨烯（GO）是石墨烯的一种衍生物，由于其固有的生物相容性，良好的载药能力以及抗菌，抗真菌等特性，已经成为了许多药物递送的关键载体。我们使用了一种称为阿拉伯胶（GA）的新型植物材料，以提高GO的溶解度，并在溶液中化学还原它。GA功能化的GO（fGO）在光热疗法治疗癌症中具有在近红外区域（NIR）吸收增加的现象。为了解可能影响其流变性质的GO的形状和尺寸效应，我们通过种子介导的方法原位合成GO@

氧化石墨烯（GO）是石墨烯的一种衍生物，由于其固有的生物相容性，良好的载药能力以及抗菌，抗真菌等特性，已经成为了许多药物递送的关键载体。

我们使用了一种称为阿拉伯胶（GA）的新型植物材料，以提高GO的溶解度，并在溶液中化学还原它。GA功能化的GO（fGO）在光热疗法治疗癌症中具有在近红外区域（NIR）吸收增加的现象。为了解可能影响其流变性质的GO的形状和尺寸效应，我们通过种子介导的方法原位合成GO@GNRs并将它们与金纳米棒（GNR）缀合。对于上述缀合物，在环境温度（28±2℃）下连接多柔比星（DOX）。还通过体外光热杀伤A549细胞系仔细研究了DOX与NIR暴露效应的释放动力学。

结果发现，NIR诱导的药物释放和光热性质的增强，这表明fGO@GNRs-DOX方法同时是化学疗法和光热疗法的理想选择。

原始出处：

Khan MS, Pandey S, et al., Graphene oxide@gold nanorods for chemo-photothermal treatment and controlled release of doxorubicin in mice Tumor. Colloids Surf B Biointerfaces. 2017 Dec 1;160:543-552. doi: 10.1016/j.colsurfb.2017.09.001. Epub 2017 Sep 4.

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    2018-12-11 sunylz

    #Bio#

    0

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    2018-04-12 waiwai3030

    #Coll#

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    2018-06-03 shanyongle

    #ACE#

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    2019-01-13 夏天与十三菇凉

    #FAC#

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    2018-03-01 李咸君

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1917937, encodeId=74b4191e93798, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Dec 11 05:52:00 CST 2018, time=2018-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783312, encodeId=4c941e833124e, content=<a href='/topic/show?id=f16a499652' target=_blank style='color:#2F92EE;'>#Coll#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4996, encryptionId=f16a499652, topicName=Coll)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=07f7192, createdName=waiwai3030, createdTime=Thu Apr 12 19:52:00 CST 2018, time=2018-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655837, encodeId=64ba165583e0e, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Sun Jun 03 16:52:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956674, encodeId=cea919566e425, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Sun Jan 13 10:52:00 CST 2019, time=2019-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291992, encodeId=fea229199276, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLwDIpSr7pXzdyP326tBaeNhGTibrZM2uPxlPgKyibofSzib032RuvVKqG9OLeicWXK5Ztyib5HxUQd5lA/132, createdBy=b37d2265675, createdName=李咸君, createdTime=Thu Mar 01 10:21:19 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291764, encodeId=46ad291e6477, content=氧化石墨烯(GO)是石墨烯的一种衍生物.由于其固有的生物相容性.良好的载药能力以及抗菌.抗真菌等特性.已经成为了许多药物递送的关键载体., beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Feb 28 20:17:24 CST 2018, time=2018-02-28, status=1, ipAttribution=)]
    2018-02-28 有备才能无患

    氧化石墨烯(GO)是石墨烯的一种衍生物.由于其固有的生物相容性.良好的载药能力以及抗菌.抗真菌等特性.已经成为了许多药物递送的关键载体.

    0