J Biomed Mater Res A:新形钛表面涂层可更好的促进成骨

2019-07-24 不详 网络

钛(Ti)植入物表面的羟基磷灰石(HAP)和TiO2的生物适应性纳米结构涂层对于生物材料 -组织骨整合是必不可少的。然而,到目前为止,还没有具体报道关注两种生物适应性涂层对前成骨细胞行为的不同影响。本文研究了前成骨细胞在纳米棒阵列形貌的HAP和TiO2涂层上的粘附,增殖和成骨潜能。 XRD,TEM和SAED分析表明,研究成功制备了棒状HAP纳米阵列和锐钛矿TiO2纳米阵列涂层,两种涂层的粗糙度和纤

钛(Ti)植入物表面的羟基磷灰石(HAP)和TiO2的生物适应性纳米结构涂层对于生物材料 -组织骨整合是必不可少的。然而,到目前为止,还没有具体报道关注两种生物适应性涂层对前成骨细胞行为的不同影响。本文研究了前成骨细胞在纳米棒阵列形貌的HAP和TiO2涂层上的粘附,增殖和成骨潜能。

XRD,TEM和SAED分析表明,研究成功制备了棒状HAP纳米阵列和锐钛矿TiO2纳米阵列涂层,两种涂层的粗糙度和纤连蛋白吸附差异不明显。除了HAP涂层上细胞的较大投影面积外,MC3T3-E1细胞在两个涂层上的粘附和增殖没有明显差异。与TiO2涂层相比,在HAP涂层上培养21天的MC3T3-E1细胞表达更高水平的run-相关的转录因子-2(Runx2),骨钙蛋白(OCN)和1型胶原蛋白(Col I)的表达,除碱性磷酸酶(ALP)外。

综上所述,该研究为智能选择生物涂层提供新的思路。

原始出处:

Pang S, Sun M, et al., Bioadaptive nanorod array topography of hydroxyapatite and TiO2 on Ti substrate to preosteoblast cell behaviors. J Biomed Mater Res A. 2019 May 30. doi: 10.1002/jbm.a.36735. 

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    2020-05-29 30397613
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    2020-03-17 sunylz
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    2019-07-26 zhaojie88
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