J Periodontal Res:种植体周围炎治疗的生物反应

2019-07-28 sunshine 译 MedSci原创

本研究旨在研究手术和抗菌治疗前后龈沟液中种植体周围炎(PIP)的生物学标志物。临床评估了48名参与者(24名健康植体和24名PIP),并且在基线时收集了两组以及手术和抗菌治疗后3个月(即n = 21个PIP完成者)患者的种植体周围龈沟液(PICF)样本。使用免疫测定法分析样品中白细胞介素-1β(IL-1β),基质金属蛋白酶-8(MMP-8)和巨噬细胞炎性蛋白-1α(MIP-1α),并比较各组之间的

本研究旨在研究手术和抗菌治疗前后龈沟液中种植体周围炎(PIP)的生物学标志物。

临床评估了48名参与者(24名健康植体和24名PIP),并且在基线时收集了两组以及手术和抗菌治疗后3个月(即n = 21个PIP完成者)患者的种植体周围龈沟液(PICF)样本。使用免疫测定法分析样品中白细胞介素-1β(IL-1β),基质金属蛋白酶-8(MMP-8)和巨噬细胞炎性蛋白-1α(MIP-1α),并比较各组之间的结果。

结果显示,与健康植入部位相比,基线种植体周围平均牙周探诊深度,探测出血百分比(P≤0.001)和PICF中的平均IL-1β浓度显著增加(17.9对1.7 pg /μL; P = 0.02)。治疗3个月后,牙周探诊深度,探诊出血,化脓(P <0.05)和MMP-8的平均浓度与基线相比明显下降(12.1 vs 6.7 ng /μL,P = 0.04)。各组之间 MIP-1α浓度无差异。

总之,该研究结果表明,PICF中IL-1β浓度的升高与PIP一致。治疗后3个月PICF中MMP-8浓度的降低与愈合生物反应一致。

原始出处:

Bhavsar I, Miller CS, et al., Biological response to peri-implantitis treatment. J Periodontal Res. 2019 Jul 18. doi: 10.1111/jre.12681.

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