Nature:科学家提出头颈癌治疗新思路

2015-02-06 生物谷 生物谷

目前头颈部的鳞状细胞癌(HNSCC)是美国最为普遍的10种癌症之一,尽管其非常流行,但研究人员对其的发病及扩散的机制却是知之甚少,近日,一篇刊登在国际著名杂志Nature上的一篇研究论文中,来自耶鲁大学医学院的研究人员就为揭示头颈癌的发病机制提供了重要的信息。头颈癌是由一种名为人乳头瘤病毒(HPV)的病毒引发的,利用来自HPV阳性和阴性患者的肿瘤组织,研究人员就对其发生的突变或致癌基因进行了全面的

目前头颈部的鳞状细胞癌(HNSCC)是美国最为普遍的10种癌症之一,尽管其非常流行,但研究人员对其的发病及扩散的机制却是知之甚少,近日,一篇刊登在国际著名杂志Nature上的一篇研究论文中,来自耶鲁大学医学院的研究人员就为揭示头颈癌的发病机制提供了重要的信息。

头颈癌是由一种名为人乳头瘤病毒(HPV)的病毒引发的,利用来自HPV阳性和阴性患者的肿瘤组织,研究人员就对其发生的突变或致癌基因进行了全面的分析和评估,研究者表示,癌基因在肿瘤的发生和转移过程中扮演着重要角色。

Yarbrough教授说道,为了帮助我们开发针对患者的个体化疗法,首先我们需要去理解是什么驱动肿瘤的发生,研究中我们发现了以前并未发现过的一些肿瘤特性,这或许最终可以帮助我们寻找有效的药物来治疗头颈癌。

在研究结果中值得注意的是,肿瘤的缺陷在不同病人中发生着广泛的变化,哪怕是在不吸烟患者和低程度吸烟的患者中也不尽相同,同时研究者还在肿瘤组织中发现了一种名为Her2的基因的表达,该基因在乳腺癌发病过程中扮演着重要角色。下一步研究者将继续对肿瘤组织进行分析以期待早日找到治疗头颈癌的实验性药物。研究人员希望通过后期更为深入的研究可以为开发头颈癌的新型疗法指明道路。


原始出处:

Cancer Genome Atlas Network.Comprehensive genomic characterization of head and neck squamous cell carcinomas.Nature. 2015 Jan 29;517(7536):576-82. doi: 10.1038/nature14129.

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    2015-10-22 晓辰
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    2015-07-19 liye789132251
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    2015-02-16 windmilL1989

    0

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    2015-02-07 medcardio

    HPV可能是口腔癌,食管癌,宫颈癌的共同致病病毒,采用疫苗预防,有望减少这几种肿瘤的发生

    0

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