肿瘤科

订阅

MedSci主页 / 所有栏目 / 肿瘤科

Scientific Reports：射频治疗能够改变癌细胞表型

2015-07-15 佚名 生物谷

射频治疗癌细胞表型
关注

关注癌细胞的生理特性变化被证明越来越有着重要意义。这是因为，通过评估癌细胞的生理特性或者表型，能够为我们提供很多细胞的行为（包括转移和细胞间交流）的信息。这些生理特征或者表型在不同类型的癌细胞、正常细胞中表现不同，而且还会随着治疗产生差异，同时在疾病的不同阶段也是大相径庭。美国德克萨斯州研究者们在Scientific Reports发文称，他们发现，胰腺癌细胞会因为射频治疗（Radiofreque

关注癌细胞的生理特性变化被证明越来越有着重要意义。这是因为，通过评估癌细胞的生理特性或者表型，能够为我们提供很多细胞的行为（包括转移和细胞间交流）的信息。这些生理特征或者表型在不同类型的癌细胞、正常细胞中表现不同，而且还会随着治疗产生差异，同时在疾病的不同阶段也是大相径庭。美国德克萨斯州研究者们在Scientific Reports发文称，他们发现，胰腺癌细胞会因为射频治疗（Radiofrequency treatment）而发生改变。

射频治疗是使用高频的无线电波来杀死癌细胞的治疗方法。射频是一种高频的无线电波，频率大概介于200~500kHz。这种高频无线电波被作用于癌症组织时，组织中存在大量电解质，在高频电磁波影响下，会引起组织出现局部的电流并产生热量，这样就会导致局部的高温，进而造成被作用区域的细胞死亡，所有射频治疗又称为射频消融。现在能够应用在临床的方法是射频治疗的一种，即侵入式射频治疗。侵入式的射频消融需要将通过电极插入肿瘤或者手术暴露肿瘤区域，再使用高频无线电产生热能。相对于侵入式射频消融，非侵入式射频消融则更加具有意义，这种方法能不用手术而增加对肿瘤部位的敏感性，然而这种方法仍在试验中。

这个来自美国德州休斯顿的课题组，在射频处理 ，通过明场显微镜、扫描电镜以及原子力显微镜以及一些其他方法的检测，胰腺癌细胞的细胞拓扑结构、形态、移动性、吸附以及分裂都收受到了影响，而产生了变化。而且不仅是癌细胞，普通细胞在射频处理前后的细胞表型也存在显著差异。例如，恶性癌细胞在射频处理后，细胞会缩小，而正常的胰腺细胞则没有明显的形态变化。对于移动性，胰腺癌细胞在射频处理后移动性增加，而普通胰腺细胞则在射频处理20小时后移动性变弱。还有些其他的数据包括细胞的存活率、细胞生物物理特性的检测，都表明了非侵入式的射频治疗会对癌细胞以及普通细胞产生不同影响。

他们还通过高通量的方法来测量了大量的细胞，以期获得更加有统计学意义的数据。同时，影像学数据还显示，他们第一次记录到了，胰腺癌细胞在射频处理后出现了纳米尺寸的通道，并且发现了有纳米颗粒能够通过这些癌细胞的孔道。这个研究第一次从细胞表型出发，分析了不同类型细胞对射频处理的不同反应。这对以后优化非侵入式的射频治疗，找到专门针对癌细胞的治疗，都积累了数据和提供了思路。

原始出处：

Matthew J. Ware, Tinger, Kevin L. Colbert, Stuart J. Corr, Paul Rees, Nadezhda Koshkina, Steven Curley, H. D. Summers & Biana Godin.Radiofrequency treatment alters cancer cell phenotype.Scientific Reports.July 13, 2015.

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=33225, encodeId=2d59332256a, content=七伤拳呀这是…, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8681634464, createdName=shenyifeiyang, createdTime=Tue Jul 21 14:14:00 CST 2015, time=2015-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32982, encodeId=45bf3298206, content=对于非完全消融区域，存在术后办法可能, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Fri Jul 17 12:18:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252040, encodeId=01861252040fe, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Jul 17 00:04:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375067, encodeId=d8cb13e506754, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Fri Jul 17 00:04:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535115, encodeId=3a561535115dc, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Fri Jul 17 00:04:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32905, encodeId=66713290554, content=这是比较可怕的，包括射频，化疗，放疗，在治疗肿瘤同时，也可能是中毒的表现发生改变，从而导致更难以治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Thu Jul 16 17:04:00 CST 2015, time=2015-07-16, status=1, ipAttribution=)]
    2015-07-21 shenyifeiyang

    七伤拳呀这是…

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=33225, encodeId=2d59332256a, content=七伤拳呀这是…, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8681634464, createdName=shenyifeiyang, createdTime=Tue Jul 21 14:14:00 CST 2015, time=2015-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32982, encodeId=45bf3298206, content=对于非完全消融区域，存在术后办法可能, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Fri Jul 17 12:18:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252040, encodeId=01861252040fe, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Jul 17 00:04:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375067, encodeId=d8cb13e506754, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Fri Jul 17 00:04:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535115, encodeId=3a561535115dc, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Fri Jul 17 00:04:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32905, encodeId=66713290554, content=这是比较可怕的，包括射频，化疗，放疗，在治疗肿瘤同时，也可能是中毒的表现发生改变，从而导致更难以治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Thu Jul 16 17:04:00 CST 2015, time=2015-07-16, status=1, ipAttribution=)]
    2015-07-17 huangwukui

    对于非完全消融区域，存在术后办法可能

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=33225, encodeId=2d59332256a, content=七伤拳呀这是…, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8681634464, createdName=shenyifeiyang, createdTime=Tue Jul 21 14:14:00 CST 2015, time=2015-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32982, encodeId=45bf3298206, content=对于非完全消融区域，存在术后办法可能, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Fri Jul 17 12:18:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252040, encodeId=01861252040fe, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Jul 17 00:04:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375067, encodeId=d8cb13e506754, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Fri Jul 17 00:04:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535115, encodeId=3a561535115dc, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Fri Jul 17 00:04:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32905, encodeId=66713290554, content=这是比较可怕的，包括射频，化疗，放疗，在治疗肿瘤同时，也可能是中毒的表现发生改变，从而导致更难以治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Thu Jul 16 17:04:00 CST 2015, time=2015-07-16, status=1, ipAttribution=)]
    2015-07-17 yxch36

    #癌细胞#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=33225, encodeId=2d59332256a, content=七伤拳呀这是…, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8681634464, createdName=shenyifeiyang, createdTime=Tue Jul 21 14:14:00 CST 2015, time=2015-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32982, encodeId=45bf3298206, content=对于非完全消融区域，存在术后办法可能, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Fri Jul 17 12:18:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252040, encodeId=01861252040fe, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Jul 17 00:04:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375067, encodeId=d8cb13e506754, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Fri Jul 17 00:04:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535115, encodeId=3a561535115dc, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Fri Jul 17 00:04:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32905, encodeId=66713290554, content=这是比较可怕的，包括射频，化疗，放疗，在治疗肿瘤同时，也可能是中毒的表现发生改变，从而导致更难以治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Thu Jul 16 17:04:00 CST 2015, time=2015-07-16, status=1, ipAttribution=)]
    2015-07-17 jichang

    #SCIE#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=33225, encodeId=2d59332256a, content=七伤拳呀这是…, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8681634464, createdName=shenyifeiyang, createdTime=Tue Jul 21 14:14:00 CST 2015, time=2015-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32982, encodeId=45bf3298206, content=对于非完全消融区域，存在术后办法可能, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Fri Jul 17 12:18:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252040, encodeId=01861252040fe, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Jul 17 00:04:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375067, encodeId=d8cb13e506754, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Fri Jul 17 00:04:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535115, encodeId=3a561535115dc, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Fri Jul 17 00:04:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32905, encodeId=66713290554, content=这是比较可怕的，包括射频，化疗，放疗，在治疗肿瘤同时，也可能是中毒的表现发生改变，从而导致更难以治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Thu Jul 16 17:04:00 CST 2015, time=2015-07-16, status=1, ipAttribution=)]
    2015-07-17 tastas

    #表型#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=33225, encodeId=2d59332256a, content=七伤拳呀这是…, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8681634464, createdName=shenyifeiyang, createdTime=Tue Jul 21 14:14:00 CST 2015, time=2015-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32982, encodeId=45bf3298206, content=对于非完全消融区域，存在术后办法可能, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Fri Jul 17 12:18:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252040, encodeId=01861252040fe, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Jul 17 00:04:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375067, encodeId=d8cb13e506754, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Fri Jul 17 00:04:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535115, encodeId=3a561535115dc, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Fri Jul 17 00:04:00 CST 2015, time=2015-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32905, encodeId=66713290554, content=这是比较可怕的，包括射频，化疗，放疗，在治疗肿瘤同时，也可能是中毒的表现发生改变，从而导致更难以治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Thu Jul 16 17:04:00 CST 2015, time=2015-07-16, status=1, ipAttribution=)]
    2015-07-16 medcardio

    这是比较可怕的，包括射频，化疗，放疗，在治疗肿瘤同时，也可能是中毒的表现发生改变，从而导致更难以治疗

    0