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PLOS ONE：我国肾移植患者活动性结核病的诊断延迟和死亡率

2018-04-18 海北 MedSci原创

肾移植结核
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最近的一项回顾性描述性研究就关注了2011年1月至2017年4月在中国浙江大学第一附属医院传染病科进行肾移植术后的结核感染情况，并探讨诊断延误和死亡的相关因素。

肾移植后患者的结核感染仍然是一个隐患。最近的一项回顾性描述性研究就关注了2011年1月至2017年4月在中国浙江大学第一附属医院传染病科进行肾移植术后的结核感染情况，并探讨诊断延误和死亡的相关因素。
该研究包括了48起案例。所有这些病例在抗结核治疗后至少进行了12个月的随访，在此期间死亡的病例除外。这48例患者移植至活动性结核的中位时间约为5.4年。从第一次就诊到诊断，有12例（25％）的时间超过30天（诊断延误）。诊断延迟超过30天的相关因素是发烧超过2周，抗生素使用超过2周。结核病复发导致9例（18.8％）患者死于抗结核治疗期间或随访期间。死亡的危险因素是严重并发症，如脑水肿，重症肺炎，肠穿孔，肝功能衰竭以及之后的多器官功能衰竭。
总之，该研究表明，我们应仔细评估结核感染的可能性，肾移植后发烧超过2周的患者或使用抗生素2周以上的患者可能需要进行诊断性抗结核治疗。严重并发症和接踵而来的多器官衰竭可能会增加这些患者的死亡率。

原始出处：

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    2018-07-09 楚秀娟

    #活动性#

    0

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    2019-01-11 119337457

    #Plos one#

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    2018-04-24 半夏微凉

    学习了谢谢分享

    0

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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Apr 21 00:35:30 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307741, encodeId=05ac30e74177, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Apr 21 00:35:25 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307740, encodeId=a80730e74022, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Apr 21 00:35:21 CST 2018, time=2018-04-21, status=1, ipAttribution=)]
    2018-04-21 xiaotao112411

    学习学习学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1723926, encodeId=bbc91e2392684, content=<a href='/topic/show?id=2d996516e7c' target=_blank style='color:#2F92EE;'>#活动性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65167, encryptionId=2d996516e7c, topicName=活动性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596833562866, createdName=楚秀娟, createdTime=Mon Jul 09 14:21:00 CST 2018, time=2018-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1790160, encodeId=4fd01e9016010, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Apr 21 00:35:30 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307741, encodeId=05ac30e74177, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Apr 21 00:35:25 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307740, encodeId=a80730e74022, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Apr 21 00:35:21 CST 2018, time=2018-04-21, status=1, ipAttribution=)]
    2018-04-21 xiaotao112411

    学习学习学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1723926, encodeId=bbc91e2392684, content=<a href='/topic/show?id=2d996516e7c' target=_blank style='color:#2F92EE;'>#活动性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65167, encryptionId=2d996516e7c, topicName=活动性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596833562866, createdName=楚秀娟, createdTime=Mon Jul 09 14:21:00 CST 2018, time=2018-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1790160, encodeId=4fd01e9016010, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Fri Jan 11 11:21:00 CST 2019, time=2019-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308736, encodeId=5e93308e36a1, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Tue Apr 24 06:57:28 CST 2018, time=2018-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307746, encodeId=dd3530e746cb, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Apr 21 00:35:30 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307741, encodeId=05ac30e74177, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Apr 21 00:35:25 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307740, encodeId=a80730e74022, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Apr 21 00:35:21 CST 2018, time=2018-04-21, status=1, ipAttribution=)]
    2018-04-21 xiaotao112411

    学习学习学习

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Apr 21 00:35:21 CST 2018, time=2018-04-21, status=1, ipAttribution=)]
    2018-04-21 xiaotao112411

    学习学习学习

    0

  8. 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    2018-04-21 xiaotao112411

    学习学习学习

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  9. 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    2018-04-21 xiaotao112411

    学习学习学习

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    2018-04-21 xiaotao112411

    学习学习学习

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