Prostate Cancer P D:EBRT附加或者不附加ADT在前列腺癌治疗中的实践模式

2018-09-13 AlexYang MedSci原创

雄激素阻断治疗(ADT)在经历体外放射治疗(EBRT)的中度和高度风险前列腺癌男性中能够改善生存。最近,研究人员利用基于群体的前瞻性疾病登记处数据,调查了EBRT附加或者不附加ADT治疗的使用情况。CaPSURE数据包括了14863名前列腺癌男性,包括了1337名在1990年到2014年诊断为局部疾病的男性,并且这些男性接受EBRT作为起始的治疗方法。研究人员利用CAPRA评分推算了前列腺癌风险。

雄激素阻断治疗(ADT)在经历体外放射治疗(EBRT)的中度和高度风险前列腺癌男性中能够改善生存。最近,研究人员利用基于群体的前瞻性疾病登记处数据,调查了EBRT附加或者不附加ADT治疗的使用情况。

CaPSURE数据包括了14863名前列腺癌男性,包括了1337名在1990年到2014年诊断为局部疾病的男性,并且这些男性接受EBRT作为起始的治疗方法。研究人员利用CAPRA评分推算了前列腺癌风险。研究发现,在1990年到2014年之间,在CaPSURE登记处,共有14010名男性诊断为局部疾病。在这些患者中,1337名男性经历了EBRT。患者的平均年龄为71岁。除了使用EBRT之外,ADT的使用率从1990年的24%增加到1996年的60%,而在2011年为47%。另外,接受ADT治疗的男性具有不同的临床特性,包括诊断时更高的PSA、更高的格林森等级和更高的CAPRA评分。ADT均值持续时间为4个月。

最后,研究人员指出,自从1990年以来,ADT与EBRT使用的结合频率不断的增加。接受ADT的男性比那些只接受EBRT治疗的男性具有更高的风险特征。在临床实践中,ADT的使用具有实质性的改变。


原始出处:

Bogdana Schmidt, Renu S. Eapen, Janet E. Cowan et al. Practice patterns of primary EBRT with and without ADT in prostate cancer treatment. Prostate Cancer P D. 31 Aug 2018.

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    2018-09-15 lsndxfj
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    2018-09-15 sunylz

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