NEJM:一起专业护理机构新冠聚集性疫情流行病学研究

2020-04-30 MedSci原创 MedSci原创

新冠病毒在这一专业的护理机构中迅速传播,超过一半的阳性感染者在检测时没有症状,无症状人群的防控是有效抑制病毒传播的关键。

专业护理机构是严重急性呼吸综合征冠状病毒2(SARS-CoV-2)疫情的高风险地区。近日研究人员对一专业护理机构中的Covid-19疫情进行了评估。
 
该机构报告1例确诊的新冠肺炎患者,研究人员对所有人员进行了两次连续流行病学调查,间隔1周,在调查中,该机构人员接受了SARS-CoV-2的鼻咽和口咽测试,包括实时逆转录聚合酶链反应(rRT-PCR)、病毒培养和测序。 记录了前14天出现的症状。结果呈阳性的无症状居民在7天后重新评估。SARS-CoV-2感染者可分为典型症状(发热、咳嗽或呼吸急促)、非典型症状、前驱症状或无症状。
 
首例患者首次检测呈阳性23天后,89名居民中有57人(64%)检测出SARS-CoV-2阳性。在参与流行调查的76名居民中,48人(63%)呈阳性。在这48名居民中,27人(56%)在测试时无症状,24人随后出现症状(发病时间中位数,4天)。24名前驱症状患者的rRT-PCR循环阈值中位数为23.1,从17名居民身上发现了活病毒。截至4月3日,在57名感染SARS-CoV-2的居民中,有11人住院(3人在重症监护室),15人死亡(死亡率26%)。
 
研究认为,新冠病毒在这一专业的护理机构中迅速传播,超过一半的阳性感染者在检测时没有症状,无症状人群的防控是有效抑制病毒传播的关键。
 
原始出处:
 
Melissa M. Arons et al. Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility. N Engl J Med, April 24, 2020.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1924837, encodeId=82db192483e92, content=<a href='/topic/show?id=44e25599eff' target=_blank style='color:#2F92EE;'>#护理机构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55997, encryptionId=44e25599eff, topicName=护理机构)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19ad38, createdName=lq1767, createdTime=Fri Dec 04 11:21:10 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1411361, encodeId=5768141136151, content=<a href='/topic/show?id=91e96538eee' target=_blank style='color:#2F92EE;'>#流行病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65387, encryptionId=91e96538eee, topicName=流行病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Sat May 02 10:21:10 CST 2020, time=2020-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1027900, encodeId=092d102e900b4, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Thu Apr 30 22:21:10 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035258, encodeId=8192103525860, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Apr 30 22:21:10 CST 2020, time=2020-04-30, status=1, ipAttribution=)]
    2020-05-02 xugumin
  3. [GetPortalCommentsPageByObjectIdResponse(id=1924837, encodeId=82db192483e92, content=<a href='/topic/show?id=44e25599eff' target=_blank style='color:#2F92EE;'>#护理机构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55997, encryptionId=44e25599eff, topicName=护理机构)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19ad38, createdName=lq1767, createdTime=Fri Dec 04 11:21:10 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1411361, encodeId=5768141136151, content=<a href='/topic/show?id=91e96538eee' target=_blank style='color:#2F92EE;'>#流行病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65387, encryptionId=91e96538eee, topicName=流行病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Sat May 02 10:21:10 CST 2020, time=2020-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1027900, encodeId=092d102e900b4, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Thu Apr 30 22:21:10 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035258, encodeId=8192103525860, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Apr 30 22:21:10 CST 2020, time=2020-04-30, status=1, ipAttribution=)]
    2020-04-30 公卫新人

    新冠肺炎,疫情何时才能消失

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1924837, encodeId=82db192483e92, content=<a href='/topic/show?id=44e25599eff' target=_blank style='color:#2F92EE;'>#护理机构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55997, encryptionId=44e25599eff, topicName=护理机构)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19ad38, createdName=lq1767, createdTime=Fri Dec 04 11:21:10 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1411361, encodeId=5768141136151, content=<a href='/topic/show?id=91e96538eee' target=_blank style='color:#2F92EE;'>#流行病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65387, encryptionId=91e96538eee, topicName=流行病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Sat May 02 10:21:10 CST 2020, time=2020-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1027900, encodeId=092d102e900b4, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Thu Apr 30 22:21:10 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035258, encodeId=8192103525860, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Apr 30 22:21:10 CST 2020, time=2020-04-30, status=1, ipAttribution=)]
    2020-04-30 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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