Obesity:孕期大量喝咖啡,会影响后代的生长发育和体脂分布

2016-04-01 Mechront 译 MedSci原创

近期发表在Obesity的研究称,怀孕期间每天喝咖啡或茶超过6杯的女性,其后代出生时候体重更低,并且从出生到6岁期间,更有可能体重增加更多、BMI更高。荷兰伊拉斯姆斯大学医学中心的Ellis Voerman硕士和同事在2001-2005年间纳入7,857名母亲和他们的孩子进行了研究,母亲的平均年龄30岁,平均妊娠BMI为22.6 kg/m²,均为白人,其中有50.4%的小孩是男孩。通过问卷调查形式


近期发表在Obesity的研究称,怀孕期间每天喝咖啡或茶超过6杯的女性,其后代出生时候体重更低,并且从出生到6岁期间,更有可能体重增加更多、BMI更高。

荷兰伊拉斯姆斯大学医学中心的Ellis Voerman硕士和同事在2001-2005年间纳入7,857名母亲和他们的孩子进行了研究,母亲的平均年龄30岁,平均妊娠BMI为22.6 kg/m²,均为白人,其中有50.4%的小孩是男孩。

通过问卷调查形式,研究者获取了母亲在孕早期、中期和晚期的咖啡因摄入量;对于孕期摄入咖啡或茶的孕妇,研究者会询问她们每天喝多少杯,喝的什么咖啡、什么茶。研究中将IU咖啡因等同于一杯咖啡(90 mg咖啡因)。对他们的孩子从出生开始进行身高体重等测量,当孩子6岁时候,还会测量他们的身体脂肪和胰岛素情况。

研究数据显示,每天摄入咖啡因≥6U的母亲与<2U的母亲相比,其后代出生时候体重更低(P < .001)。每天摄入咖啡因4-5.9U和≥6U的母亲与<2U的母亲相比,孩子儿童期BMI会更高(16 kg/m² 和16.1 kg/m² vs. 15.9 kg/m²)。每天摄入咖啡因≥6U的母亲与<2U的母亲相比,A/G脂肪比例更高(0.25 vs. 0.24; P = .197)。研究者没有发现孩子的胰岛素或C肽水平差异。

“虽然观察到了差异都比较小,并且没有造成直接的不良临床结局,但是我们的研究结果也表明了,孕期摄入咖啡因 会影响婴幼儿和儿童的生长,以及脂肪的分布。”研究者写道,“在未来还需要更大更长期的研究,探究孕期摄入咖啡因对后代肥胖问题的影响。”

原始出处:

Voerman E, et al. Maternal caffeine intake during pregnancy, early growth, and body fat distribution at school age.Obesity. 2016;doi:10.1002/oby.21466.

Maternal caffeine intake may lead to higher weight gain, BMI in offspring.Healio.March 31, 2016

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    2016-08-30 智慧医人
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    2016-05-07 1dd8c52fm63(暂无匿称)

    哪有怀孕还喝大量咖啡的孕妇啊!

    0

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    2016-05-05 1dec631em90(暂无匿称)

    孕妇最好不喝咖啡

    0

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    2016-04-03 neurowu
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    2016-04-03 lingaifan
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    2016-04-03 skhzy

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