Ann Rheum Dis:银屑病关节炎中的背痛

2018-08-05 xiangting MedSci原创

在确定PsA的轴向受累方面,风湿病医师判断的IBP或为强直性脊柱炎制定的IBP标准表现不佳。

这项研究目的是确定风湿病医师判断的炎症性背痛(IBP)与定义银屑病关节炎患者(PsA)IBP标准之间的一致性,和IBP在识别PsA轴向受累中的预测价值。

研究人员使用前瞻性收集的数据,利用kappa系数分析了风湿病医师判断的IBP与IBP标准(Calin、Rudwaleit和国际脊柱关节炎协会评估)之间的一致性。还确定了背痛、风湿病医师判断的IBP和3个IBP标准对发现轴向PsA(AxPsA)的敏感性、特异性和似然比。最后,研究人员比较了有或没有背痛的伴轴向影像学改变PsA患者的临床、遗传标记物。

共确定了171例患者(52%为男性,平均年龄46.6岁)。96例患者(56.13%)报告了慢性背痛。65例患者(38.01%)有IBP。54例患者(32%)有脊柱影像学改变证据。使用Calin标准时风湿病医师判断的IBP和IBP标准之间的一致性最高(0.70)。Rudwaleit标准存在影像性轴向受累的阳性似然比最高(2.17)。除了背痛患者的Bath强直性脊柱炎疾病活动指数较高和人类白细胞抗原-B*38患病率较低之外,没有发现伴或不伴背痛的AxPsA患者之间存在差异。

在确定PsA的轴向受累方面,风湿病医师判断的IBP或为强直性脊柱炎制定的IBP标准表现不佳。

原始出处:

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    2018-08-07 lmm397
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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sun Aug 05 12:00:12 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336616, encodeId=19d43366164c, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Aug 05 11:48:25 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336605, encodeId=816033660552, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Aug 05 10:27:17 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336604, encodeId=db1d33660435, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Aug 05 10:27:13 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336603, encodeId=fd2c33660380, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, 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level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Aug 05 10:26:58 CST 2018, time=2018-08-05, status=1, ipAttribution=)]
    2018-08-05 医者仁心5538

    学习了

    0

  5. 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level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Aug 05 10:26:58 CST 2018, time=2018-08-05, status=1, ipAttribution=)]
    2018-08-05 清风拂面

    谢谢分享学习

    0

  6. 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level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Aug 05 10:26:58 CST 2018, time=2018-08-05, status=1, ipAttribution=)]
    2018-08-05 Y—xianghai

    学习了长知识

    0

  7. 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level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Aug 05 10:26:58 CST 2018, time=2018-08-05, status=1, ipAttribution=)]
    2018-08-05 Y—xianghai

    学习了长知识

    0

  8. 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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Aug 05 10:27:17 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336604, encodeId=db1d33660435, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Aug 05 10:27:13 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336603, encodeId=fd2c33660380, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, 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level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Aug 05 10:26:58 CST 2018, time=2018-08-05, status=1, ipAttribution=)]
    2018-08-05 Y—xianghai

    学习了长知识

    0

  9. 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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Aug 05 10:27:17 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336604, encodeId=db1d33660435, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Aug 05 10:27:13 CST 2018, time=2018-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336603, encodeId=fd2c33660380, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, 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level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Aug 05 10:26:58 CST 2018, time=2018-08-05, status=1, ipAttribution=)]
    2018-08-05 Y—xianghai

    学习了长知识

    0

  10. 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level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Aug 05 10:26:58 CST 2018, time=2018-08-05, status=1, ipAttribution=)]
    2018-08-05 Y—xianghai

    学习了长知识

    0

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治疗与总的恶性肿瘤风险升高呈显著正相关,使用常规合成疾病缓解抗风湿药物(csDMARDs)治疗的PsA患者的癌症风险升高。

J Rheumatol:生物靶向合成药物对银屑病关节炎患者工作效率的影响

使用IFX、GOL、CZP、乌司奴单抗和阿普斯特治疗可以改善自我报告的工作效率。

Ann Rheum Dis:苏金单抗改善活动性银屑病关节炎的症状并抑制影像学进展

24周时与安慰剂比较,Sc苏金单抗300mg和150mg伴和不伴LD显著改善PsA患者的临床症状,并抑制影像学结构进展。

J Rheumatol:银屑病关节炎的医师全面评估:多中心GRAPPA研究

通过VAS评估PGA是评价MSK和皮肤病疾病活动性的可靠工具。

J Rheumatol:银屑病患者心血管危险因素诊断和治疗的差距

很大比例的银屑病和PsA患者的高血压和血脂异常存在漏诊和治疗不足。