Hypertension:血压评估卒中风险受年龄影响

2012-10-03 高晓方译 医学论坛网

  欧洲学者的一项研究表明,62岁之前应同时利用收缩压和舒张压(SBP/DBP)评估卒中风险;62岁之后应重点关注SBP并且不应忽视极低DBP的潜在危害。论文于2012年9月24日在线发表于《高血压》(Hypertension)杂志。   此项研究的68551例受试者来自于MORGAM计划。受试者均无心血管疾病并且未接受降压治疗,平均随访时间为13.2年,卒中发生率为2.8%。利用SBP/DBP

  欧洲学者的一项研究表明,62岁之前应同时利用收缩压和舒张压(SBP/DBP)评估卒中风险;62岁之后应重点关注SBP并且不应忽视极低DBP的潜在危害。论文于2012年9月24日在线发表于《高血压》(Hypertension)杂志。

  此项研究的68551例受试者来自于MORGAM计划。受试者均无心血管疾病并且未接受降压治疗,平均随访时间为13.2年,卒中发生率为2.8%。利用SBP/DBP每升高10/5 mmHg的危险比(HR)分析卒中风险。

  结果显示,卒中风险与SBP/DBP ≥71 mmHg呈正相关(HR 1.15/1.06),与DBP <71 mmHg呈负相关(HR 0.88)。DBP危险比随年龄增长而降低,并且不受其他心血管危险因素影响。在考虑到年龄×DBP交互作用的情况下,SBP/DBP ≥71 mmHg在62岁之前均与卒中风险显著相关。DBP <71 mmHg在50岁时具有统计学意义并且与卒中风险呈反比关系。

  链接:

Vishram JK, Borglykke A, Andreasen AH, Jeppesen J, Ibsen H, Jørgensen T, Broda G, Palmieri L, Giampaoli S, Donfrancesco C, Kee F, Mancia G, Cesana G, Kuulasmaa K, Sans S, Olsen MH; On behalf of the MORGAM Project.Impact of Age on the Importance of Systolic and Diastolic Blood Pressures for Stroke Risk: The MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project. Hypertension. 2012 Sep 24

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