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J Womens Health：为什么来大姨妈时会痛不欲生？

2016-06-24 佚名 生物谷

大姨妈
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最近，科学家们找到了某些女性在经历经期前综合征（PMS）或生理期时会十分痛苦的原因。在这项研究中，科学家们发现一种炎性生物标记与PMS严重程度之间的关系，这表明急性的炎症反应能够影响"腹部绞痛、肿胀"等经期的不适症状。很长时间以来，研究者们已经知道抗炎药物能够有效帮助女性渡过经期反应，医生们也建议他们的患者使用上述方法缓解子宫的不良反应。但最近这一研究是首次大规模地鉴定了炎症反应与PMS之间的生物

最近，科学家们找到了某些女性在经历经期前综合征（PMS）或生理期时会十分痛苦的原因。

在这项研究中，科学家们发现一种炎性生物标记与PMS严重程度之间的关系，这表明急性的炎症反应能够影响"腹部绞痛、肿胀"等经期的不适症状。

很长时间以来，研究者们已经知道抗炎药物能够有效帮助女性渡过经期反应，医生们也建议他们的患者使用上述方法缓解子宫的不良反应。但最近这一研究是首次大规模地鉴定了炎症反应与PMS之间的生物学联系。尽管上述结果还比较初步，但能够帮助科学家们寻找更加有效的治疗手段，而不仅仅是一味地使用OTC止痛药。

通过对2939名女性进行调查，加州戴维斯分校的研究者们发现PMS的严重程度与一类叫做C-reactive protein（hs-CRP）的高敏感蛋白质的存在有正向相关性。

Hs-CRP是机体炎症反应的生物标记，研究者们认为这一蛋白的含量越高，标志着机体承受的炎症反应强度会越大，以及PMS的炎症程度越高。

"PMS，包括异常的腹痛/背痛，食欲旺盛，体重增加，肿胀，乳房疼痛等等。这些症状都与hs-CRP的含量有正向相关性"研究者们说道。

这一结果十分有意义，因为世界上大约有80%的女性都承受着PMS的困扰，而目前对于这一症状的产生或是治疗手段都没有得到清楚的揭示。目前最好的治疗药物是ibuprofen（一类OTC止痛剂），但也仅仅能解决抗炎的问题。

另外有一种新型的设备能够通过电流的方式"关闭"生理期的不适感，但对于PMS症状却没有缓解的效果。

今年早期，来自伦敦学院大学的生殖健康学教授John Guillebaud称生理期疼痛的严重程度可以与心脏病匹敌，但由于男性并没有这种困扰，因此很容易被忽略。

很多女性宇航员在太空任务期间都想方设法跳过生理期，而普通的女性也应该有这样的选择。

但是如果我们能够找到导致PMS的生物学因子，那么就有可能开发出更好的治疗方法，至少能够对高发人群进行准确的诊断。这一发现也有助于我们在这一方面进一步的研究。

相关结果发表在《Journal of Women's Health》杂志上。

原始出处

Ellen B. Gold, PhD, Craig Wells, BA, and Marianne O'Neill Rasor, MA.The Association of Inflammation with Premenstrual Symptoms.J Womens Health.2016

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    2016-11-18 shizhenshan

    #ALT#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1861059, encodeId=fd9118610597d, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Fri Nov 18 00:35:00 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992224, encodeId=ad0a19922240a, content=<a href='/topic/show?id=8915436e966' target=_blank style='color:#2F92EE;'>#大姨妈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43679, encryptionId=8915436e966, topicName=大姨妈)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e1c493, createdName=xugc, createdTime=Fri Nov 25 07:35:00 CST 2016, time=2016-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91509, encodeId=0a1791509a9, content=有意义，可以借鉴, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Wed Jun 29 06:14:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91183, encodeId=1eb691183a7, content=好文章，值得收藏！, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIsrUxHnicsiaqwzJibCks60HOicbEAgbNzUiciboMJDzsWg16OHTeNHhyYvTg6TDXTlOx7icnhttCYYe2ujYt0yND7dYusOsibl9XnQCE/0, createdBy=7ad21722200, createdName=jaysppr, createdTime=Sun Jun 26 15:04:00 CST 2016, time=2016-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621578, encodeId=b4e316215e825, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Sun Jun 26 13:35:00 CST 2016, time=2016-06-26, status=1, ipAttribution=)]
    2016-11-25 xugc

    #大姨妈#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1861059, encodeId=fd9118610597d, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Fri Nov 18 00:35:00 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992224, encodeId=ad0a19922240a, content=<a href='/topic/show?id=8915436e966' target=_blank style='color:#2F92EE;'>#大姨妈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43679, encryptionId=8915436e966, topicName=大姨妈)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e1c493, createdName=xugc, createdTime=Fri Nov 25 07:35:00 CST 2016, time=2016-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91509, encodeId=0a1791509a9, content=有意义，可以借鉴, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Wed Jun 29 06:14:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91183, encodeId=1eb691183a7, content=好文章，值得收藏！, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIsrUxHnicsiaqwzJibCks60HOicbEAgbNzUiciboMJDzsWg16OHTeNHhyYvTg6TDXTlOx7icnhttCYYe2ujYt0yND7dYusOsibl9XnQCE/0, createdBy=7ad21722200, createdName=jaysppr, createdTime=Sun Jun 26 15:04:00 CST 2016, time=2016-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621578, encodeId=b4e316215e825, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Sun Jun 26 13:35:00 CST 2016, time=2016-06-26, status=1, ipAttribution=)]
    2016-06-29 午夜星河

    有意义，可以借鉴

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1861059, encodeId=fd9118610597d, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Fri Nov 18 00:35:00 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992224, encodeId=ad0a19922240a, content=<a href='/topic/show?id=8915436e966' target=_blank style='color:#2F92EE;'>#大姨妈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43679, encryptionId=8915436e966, topicName=大姨妈)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e1c493, createdName=xugc, createdTime=Fri Nov 25 07:35:00 CST 2016, time=2016-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91509, encodeId=0a1791509a9, content=有意义，可以借鉴, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Wed Jun 29 06:14:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91183, encodeId=1eb691183a7, content=好文章，值得收藏！, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEIsrUxHnicsiaqwzJibCks60HOicbEAgbNzUiciboMJDzsWg16OHTeNHhyYvTg6TDXTlOx7icnhttCYYe2ujYt0yND7dYusOsibl9XnQCE/0, createdBy=7ad21722200, createdName=jaysppr, createdTime=Sun Jun 26 15:04:00 CST 2016, time=2016-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621578, encodeId=b4e316215e825, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Sun Jun 26 13:35:00 CST 2016, time=2016-06-26, status=1, ipAttribution=)]
    2016-06-26 jaysppr

    好文章，值得收藏！

    0

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    2016-06-26 yyanpro@28cn.c

    #Health#

    0

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