JSCRM:两因子sox2和pax6直接将皮肤细胞直接转分化为神经前体细胞

2012-12-09 MedSci MedSci原创

     新西兰奥克兰大学大脑研究中心的研究人员成功地将人皮肤细胞直接地转化为不成熟的脑细胞或者说神经前体细胞(neural precursor cell)。他们开发出一种快速和有效的方法来完成这种转化,同时也不用经历转化为类似胚胎干细胞的诱导性多能干细胞中间阶段。     Bronwen Connor说,“对全世界的干细胞

     新西兰奥克兰大学大脑研究中心的研究人员成功地将人皮肤细胞直接地转化为不成熟的脑细胞或者说神经前体细胞(neural precursor cell)。他们开发出一种快速和有效的方法来完成这种转化,同时也不用经历转化为类似胚胎干细胞的诱导性多能干细胞中间阶段。     Bronwen Connor说,“对全世界的干细胞研究而言,这是一次具有重大意义的进步。它有潜力导致人们对诸如亨丁顿舞蹈症、帕金森病和阿尔茨海默病之类的神经退化疾病产生新的认识。”     这项研究的一个主要优势在于,它能够让探究人员从患有基因相关性神经系统疾病的病人体内采集皮肤细胞,然后利用这些细胞构建出受这些疾病影响的脑细 胞。这将有助于人们深入理解导致这些疾病的机制。它将允许人们在大脑组织上测试潜在的治疗方法。它也将允许人们在未来有可能替代受损的脑细胞。     尽管全世界的许多研究小组也正在研究将皮肤细胞转化为脑细胞的新方法,但是在当前这项研究中,奥克兰大学大脑研究中心研究人员开

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2053146, encodeId=ac2a205314622, content=<a href='/topic/show?id=20bf932e3bb' target=_blank style='color:#2F92EE;'>#转分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93273, encryptionId=20bf932e3bb, topicName=转分化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Mon Nov 18 07:22:00 CST 2013, time=2013-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668753, encodeId=b1db1668e53c0, content=<a href='/topic/show?id=23f8165668b' target=_blank style='color:#2F92EE;'>#Sox2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16566, encryptionId=23f8165668b, topicName=Sox2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=270626409933, createdName=doctorzheng, createdTime=Mon Jun 03 07:22:00 CST 2013, time=2013-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438273, encodeId=a75014382e3b9, content=<a href='/topic/show?id=c8a526638f6' target=_blank style='color:#2F92EE;'>#体细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26638, encryptionId=c8a526638f6, topicName=体细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Dec 11 05:22:00 CST 2012, time=2012-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568853, encodeId=be291568853f2, content=<a href='/topic/show?id=8a53e209452' target=_blank style='color:#2F92EE;'>#皮肤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72094, encryptionId=8a53e209452, topicName=皮肤细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635f15466557, createdName=marongnuan, createdTime=Tue Dec 11 05:22:00 CST 2012, time=2012-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614825, encodeId=73ae1614825e7, content=<a href='/topic/show?id=af2116063a2' target=_blank style='color:#2F92EE;'>#SCR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16063, encryptionId=af2116063a2, topicName=SCR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=914b19549580, createdName=12498877m104暂无昵称, createdTime=Tue Dec 11 05:22:00 CST 2012, time=2012-12-11, status=1, ipAttribution=)]
    2013-11-18 sjq027
  2. [GetPortalCommentsPageByObjectIdResponse(id=2053146, encodeId=ac2a205314622, content=<a href='/topic/show?id=20bf932e3bb' target=_blank style='color:#2F92EE;'>#转分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93273, encryptionId=20bf932e3bb, topicName=转分化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Mon Nov 18 07:22:00 CST 2013, time=2013-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668753, encodeId=b1db1668e53c0, content=<a href='/topic/show?id=23f8165668b' target=_blank style='color:#2F92EE;'>#Sox2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16566, encryptionId=23f8165668b, topicName=Sox2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=270626409933, createdName=doctorzheng, createdTime=Mon Jun 03 07:22:00 CST 2013, time=2013-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438273, encodeId=a75014382e3b9, content=<a href='/topic/show?id=c8a526638f6' target=_blank style='color:#2F92EE;'>#体细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26638, encryptionId=c8a526638f6, topicName=体细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Dec 11 05:22:00 CST 2012, time=2012-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568853, encodeId=be291568853f2, content=<a href='/topic/show?id=8a53e209452' target=_blank style='color:#2F92EE;'>#皮肤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72094, encryptionId=8a53e209452, topicName=皮肤细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635f15466557, createdName=marongnuan, createdTime=Tue Dec 11 05:22:00 CST 2012, time=2012-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614825, encodeId=73ae1614825e7, content=<a href='/topic/show?id=af2116063a2' target=_blank style='color:#2F92EE;'>#SCR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16063, encryptionId=af2116063a2, topicName=SCR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=914b19549580, createdName=12498877m104暂无昵称, createdTime=Tue Dec 11 05:22:00 CST 2012, time=2012-12-11, status=1, ipAttribution=)]
    2013-06-03 doctorzheng
  3. [GetPortalCommentsPageByObjectIdResponse(id=2053146, encodeId=ac2a205314622, content=<a href='/topic/show?id=20bf932e3bb' target=_blank style='color:#2F92EE;'>#转分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93273, encryptionId=20bf932e3bb, topicName=转分化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Mon Nov 18 07:22:00 CST 2013, time=2013-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668753, encodeId=b1db1668e53c0, content=<a href='/topic/show?id=23f8165668b' target=_blank style='color:#2F92EE;'>#Sox2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16566, encryptionId=23f8165668b, topicName=Sox2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=270626409933, createdName=doctorzheng, createdTime=Mon Jun 03 07:22:00 CST 2013, time=2013-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438273, encodeId=a75014382e3b9, content=<a href='/topic/show?id=c8a526638f6' target=_blank style='color:#2F92EE;'>#体细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26638, encryptionId=c8a526638f6, topicName=体细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Dec 11 05:22:00 CST 2012, time=2012-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568853, encodeId=be291568853f2, content=<a href='/topic/show?id=8a53e209452' target=_blank style='color:#2F92EE;'>#皮肤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72094, encryptionId=8a53e209452, topicName=皮肤细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635f15466557, createdName=marongnuan, createdTime=Tue Dec 11 05:22:00 CST 2012, time=2012-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614825, encodeId=73ae1614825e7, content=<a href='/topic/show?id=af2116063a2' target=_blank style='color:#2F92EE;'>#SCR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16063, encryptionId=af2116063a2, topicName=SCR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=914b19549580, createdName=12498877m104暂无昵称, createdTime=Tue Dec 11 05:22:00 CST 2012, time=2012-12-11, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2053146, encodeId=ac2a205314622, content=<a href='/topic/show?id=20bf932e3bb' target=_blank style='color:#2F92EE;'>#转分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93273, encryptionId=20bf932e3bb, topicName=转分化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Mon Nov 18 07:22:00 CST 2013, time=2013-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668753, encodeId=b1db1668e53c0, content=<a href='/topic/show?id=23f8165668b' target=_blank style='color:#2F92EE;'>#Sox2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16566, encryptionId=23f8165668b, topicName=Sox2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=270626409933, createdName=doctorzheng, createdTime=Mon Jun 03 07:22:00 CST 2013, time=2013-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438273, encodeId=a75014382e3b9, content=<a href='/topic/show?id=c8a526638f6' target=_blank style='color:#2F92EE;'>#体细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26638, encryptionId=c8a526638f6, topicName=体细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Dec 11 05:22:00 CST 2012, time=2012-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568853, encodeId=be291568853f2, content=<a href='/topic/show?id=8a53e209452' target=_blank style='color:#2F92EE;'>#皮肤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72094, encryptionId=8a53e209452, topicName=皮肤细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635f15466557, createdName=marongnuan, createdTime=Tue Dec 11 05:22:00 CST 2012, time=2012-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614825, encodeId=73ae1614825e7, content=<a href='/topic/show?id=af2116063a2' target=_blank style='color:#2F92EE;'>#SCR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16063, encryptionId=af2116063a2, topicName=SCR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=914b19549580, createdName=12498877m104暂无昵称, createdTime=Tue Dec 11 05:22:00 CST 2012, time=2012-12-11, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2053146, encodeId=ac2a205314622, content=<a href='/topic/show?id=20bf932e3bb' target=_blank style='color:#2F92EE;'>#转分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93273, encryptionId=20bf932e3bb, topicName=转分化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Mon Nov 18 07:22:00 CST 2013, time=2013-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668753, encodeId=b1db1668e53c0, content=<a href='/topic/show?id=23f8165668b' target=_blank style='color:#2F92EE;'>#Sox2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16566, encryptionId=23f8165668b, topicName=Sox2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=270626409933, createdName=doctorzheng, createdTime=Mon Jun 03 07:22:00 CST 2013, time=2013-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438273, encodeId=a75014382e3b9, content=<a href='/topic/show?id=c8a526638f6' target=_blank style='color:#2F92EE;'>#体细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26638, encryptionId=c8a526638f6, topicName=体细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Dec 11 05:22:00 CST 2012, time=2012-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568853, encodeId=be291568853f2, content=<a href='/topic/show?id=8a53e209452' target=_blank style='color:#2F92EE;'>#皮肤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72094, encryptionId=8a53e209452, topicName=皮肤细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635f15466557, createdName=marongnuan, createdTime=Tue Dec 11 05:22:00 CST 2012, time=2012-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614825, encodeId=73ae1614825e7, content=<a href='/topic/show?id=af2116063a2' target=_blank style='color:#2F92EE;'>#SCR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16063, encryptionId=af2116063a2, topicName=SCR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=914b19549580, createdName=12498877m104暂无昵称, createdTime=Tue Dec 11 05:22:00 CST 2012, time=2012-12-11, status=1, ipAttribution=)]